{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:59:51Z","timestamp":1791496791072,"version":"4.3.4"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"25","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["81371675"],"award-info":[{"award-number":["81371675"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of?Hunan Province","award":["2024JJ5342"],"award-info":[{"award-number":["2024JJ5342"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2026,7,1]]},"DOI":"10.1021\/acsami.6c05969","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T11:26:57Z","timestamp":1782127617000},"page":"34932-34951","source":"Crossref","is-referenced-by-count":1,"title":["FAP-\u03b1-Responsive Size-Transformable Lipid Nanoparticles for Stromal Remodeling and Enhanced Drug Penetration in Fibrotic Hepatocellular Carcinoma"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5823-987X","authenticated-orcid":true,"given":"Li","family":"Xiang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences","place":["Hengyang, China"]},{"name":"University of South China","place":["Hengyang, China"]},{"name":"The First Affiliated Hospital, Department of Pharmacy, Hengyang Medical School","place":["Hengyang, China"]},{"name":"University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery","place":["Changsha, China"]},{"name":"The Second Xiangya Hospital of Central South University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukang","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences","place":["Hengyang, China"]},{"name":"University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjing","family":"Xiang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences","place":["Hengyang, China"]},{"name":"University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangqiang","family":"Jiao","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences","place":["Hengyang, China"]},{"name":"University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sainan","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences","place":["Hengyang, China"]},{"name":"University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences","place":["Hengyang, China"]},{"name":"University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences","place":["Hengyang, China"]},{"name":"University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4810-1922","authenticated-orcid":true,"given":"Yuping","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences","place":["Hengyang, China"]},{"name":"University of South China","place":["Hengyang, China"]},{"name":"MOE Key Laboratory of Rare Pediatric Diseases, Hengyang Medical School","place":["Hengyang, China"]},{"name":"University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.18"},{"issue":"2","key":"ref3\/cit3","first-page":"98","volume":"8","author":"Paget S.","year":"1989","journal-title":"Cancer Metastasis Rev."},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-022-00357-2"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00821-z"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00642-5"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000056"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030575"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.188945"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02376-y"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S363456"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114505"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.10.002"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20588-0"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.01.043"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200462960"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.10.012"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.03.001"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092027"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-020-00488-y"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113783"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.smaim.2025.07.004"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.10.046"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-01995-4"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29186-8"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20853"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125190"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202500176"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.080"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202106296"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.02.040"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-024-00747-z"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-025-10788-5"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c23137"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1007\/s42242-020-00105-4"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2025.114839"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2024.135277"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2026.139554"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b02016"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.1c00023"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2022.12.005"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-01995-4"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52308-3"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29186-8"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1172\/JCI94258"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2025.04.016"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.10.010"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.4c01135"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125403"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.07.035"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-50680-6"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605x\/adf47f"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR04465B"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14010143"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b03913"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300351"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01509-2"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2002.01503.x"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20853"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2018.06.005"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.07.015"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.10.046"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c03799"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c15562"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31848"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05289-6"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31792"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217243"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl7209"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c05969","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c05969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:12:50Z","timestamp":1782922370000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.6c05969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":70,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.1021\/acsami.6c05969"],"URL":"https:\/\/doi.org\/10.1021\/acsami.6c05969","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]}}}