{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:12:51Z","timestamp":1789758771322,"version":"4.0.1"},"reference-count":89,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["B2023202030"],"award-info":[{"award-number":["B2023202030"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["B2024202013"],"award-info":[{"award-number":["B2024202013"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["B2026202007"],"award-info":[{"award-number":["B2026202007"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3404200"],"award-info":[{"award-number":["2023YFC3404200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003482","name":"Department of Education of Hebei Province","doi-asserted-by":"publisher","award":["BJ2025110"],"award-info":[{"award-number":["BJ2025110"]}],"id":[{"id":"10.13039\/501100003482","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing-Tianjin-Hebei Natural Science Foundation Cooperation Project","award":["25JJJJC0020"],"award-info":[{"award-number":["25JJJJC0020"]}]},{"name":"Government Guide the Development of Local Science and Technology Special Funds","award":["226Z2401G"],"award-info":[{"award-number":["226Z2401G"]}]},{"name":"Government Guide the Development of Local Science and Technology Special Funds","award":["246Z3707G"],"award-info":[{"award-number":["246Z3707G"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cells actively remodel the extracellular matrix (ECM) through a repertoire of mechanically driven behaviors, including traction force generation, migration, proteolysis, and long-term deposition. While these processes are often discussed separately, emerging evidence suggests that they are coordinated through shared mechanochemical signaling modules. In parallel, advances in hydrogel-based biomaterials have revealed that ECM mechanics, including stiffness, viscoelastic dissipation, degradability, and temporal dynamics, can systematically program cellular remodeling behaviors. In this review, we discuss the close interplay among ECM mechanics, mechanosensitive ion channels, and cell remodeling behaviors, with particular emphasis on ion channels as mechanochemical control nodes that connect material-defined mechanical cues to cytoskeletal tension, adhesion dynamics, and transcriptional reprogramming. Focusing on Piezo1, TRPV4, TRPM7, and TRPC6, we discuss how localized Ca2+ entry events decode extracellular mechanics into behavior-specific outputs across distinct remodeling modalities. We further discuss how engineered hydrogels define the mechanical environment that shapes channel-mediated signaling, thereby shaping when, where, and how ECM remodeling occurs. Together, this perspective positions mechanosensitive ion channels as a mechanochemical control layer that links dynamic material environments to coordinated cellular behaviors, highlighting their relevance to the design of biomaterials that actively direct tissue remodeling.<\/jats:p>","DOI":"10.1021\/acsami.6c06015","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T17:02:16Z","timestamp":1786640536000},"page":"44700-44723","source":"Crossref","is-referenced-by-count":0,"title":["Reciprocal Coupling among Extracellular Matrix Mechanics, Mechanosensitive Ion Channels, and Cell Remodeling Behaviors"],"prefix":"10.1021","volume":"18","author":[{"given":"Zhanshuo","family":"Cao","sequence":"first","affiliation":[{"name":"Hebei University of Technology , , ,","place":["Tianjin, China, 300401"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boying","family":"Li","sequence":"additional","affiliation":[{"name":"Hebei University of Technology , , ,","place":["Tianjin, China, 300401"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-4862","authenticated-orcid":true,"given":"Liang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Hebei University of Technology , , ,","place":["Tianjin, China, 300401"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongwei","family":"Qu","sequence":"additional","affiliation":[{"name":"Hebei University of Technology , , ,","place":["Tianjin, China, 300401"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1939-2265","authenticated-orcid":true,"given":"Chengfen","family":"Xing","sequence":"additional","affiliation":[{"name":"Hebei University of Technology , , ,","place":["Tianjin, China, 300401"]},{"name":"Hebei University of Technology , , ,","place":["Tianjin, China, 300401"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"2026091814064520900_cit1","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.bioactmat.2021.08.002","article-title":"Cell-matrix reciprocity in 3D culture models with nonlinear elasticity","volume":"9","author":"Liu","year":"2022","journal-title":"Bioact. Mater."},{"key":"2026091814064520900_cit2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.actbio.2021.04.020","article-title":"Engineering hydrogels for personalized disease modeling and regenerative medicine","volume":"132","author":"Tayler","year":"2021","journal-title":"Acta Biomater."},{"issue":"1","key":"2026091814064520900_cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s44341-025-00014-6","article-title":"The role of extracellular matrix viscoelasticity in development and disease","volume":"2","author":"Courbot","year":"2025","journal-title":"NPJ Biol. Phys. Mech."},{"issue":"3","key":"2026091814064520900_cit4","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/nmat4489","article-title":"Hydrogels with tunable stress relaxation regulate stem cell fate and activity","volume":"15","author":"Chaudhuri","year":"2016","journal-title":"Nat. Mater."},{"issue":"1","key":"2026091814064520900_cit5","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.stem.2024.09.016","article-title":"Photo-tunable hydrogels reveal cellular sensing of rapid rigidity changes through the accumulation of mechanical signaling molecules","volume":"32","author":"Yang","year":"2025","journal-title":"Cell Stem Cell"},{"issue":"9","key":"2026091814064520900_cit6","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1038\/s41563-025-02234-6","article-title":"Hybrid hydrogel-extracellular matrix scaffolds identify biochemical and mechanical signatures of cardiac ageing","volume":"24","author":"Sun","year":"2025","journal-title":"Nat. Mater."},{"key":"2026091814064520900_cit7","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo1461","article-title":"Force and cell state-dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry","volume":"8","author":"Yao","year":"2022","journal-title":"Sci. Adv."},{"issue":"10","key":"2026091814064520900_cit8","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1038\/s12276-025-01546-6","article-title":"An overview of mechanical microenvironment and mechanotransduction in intervertebral disc degeneration","volume":"57","author":"Ke","year":"2025","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"2026091814064520900_cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01501-9","article-title":"Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets","volume":"8","author":"Di","year":"2023","journal-title":"Signal Transduct Target Ther."},{"issue":"2","key":"2026091814064520900_cit10","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1089\/adt.2012.474","article-title":"Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure","volume":"11","author":"Karsdal","year":"2013","journal-title":"Assay Drug Dev. Technol."},{"key":"2026091814064520900_cit11","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1354132","article-title":"Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist","volume":"12","author":"Crossley","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"2026091814064520900_cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18794-x","article-title":"Concepts of extracellular matrix remodelling in tumour progression and metastasis","volume":"11","author":"Winkler","year":"2020","journal-title":"Nat. Commun."},{"key":"2026091814064520900_cit13","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.matbio.2024.10.007","article-title":"Remodeling of the extracellular matrix by serine proteases as a prerequisite for cancer initiation and progression","volume":"134","author":"Wenta","year":"2024","journal-title":"Matrix Biol."},{"issue":"13","key":"2026091814064520900_cit14","doi-asserted-by":"publisher","first-page":"3788","DOI":"10.1111\/febs.70292","article-title":"Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior","volume":"293","author":"Solomonov","year":"2025","journal-title":"FEBS J."},{"issue":"16","key":"2026091814064520900_cit15","doi-asserted-by":"publisher","first-page":"4075","DOI":"10.1073\/pnas.1722619115","article-title":"Cell contraction induces long-ranged stress stiffening in the extracellular matrix","volume":"115","author":"Han","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026091814064520900_cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s44341-025-00027-1","article-title":"The role of dynamic reciprocity in 3D cell migration: connecting cell and matrix mechanics to migratory plasticity","volume":"2","author":"Duggan","year":"2025","journal-title":"npj Biol. Phys. Mech."},{"key":"2026091814064520900_cit17","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/s41556-025-01663-4","article-title":"Dynamic regulation of integrin \u03b21 phosphorylation supports invasion of breast cancer cells","volume":"27","author":"Conway","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"2026091814064520900_cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s44324-025-00063-4","article-title":"ECM formation and degradation during fibrosis, repair, and regeneration. npj Metab","volume":"3","author":"Mayorca-Guiliani","year":"2025","journal-title":"Health Dis."},{"issue":"1","key":"2026091814064520900_cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09121-0","article-title":"Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"2026091814064520900_cit20","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7365","article-title":"Substrate stress relaxation regulates cell spreading","volume":"6","author":"Chaudhuri","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"2026091814064520900_cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54880-0","article-title":"Visible light-responsive hydrogels for cellular dynamics and spatiotemporal viscoelastic regulation","volume":"16","author":"Lu","year":"2025","journal-title":"Nat. Commun."},{"issue":"15","key":"2026091814064520900_cit22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.221693412","article-title":"Synthetic fibrous hydrogels as a platform to decipher cell\u2013matrix mechanical interactions","volume":"120","author":"Yuan","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"28","key":"2026091814064520900_cit23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2317711121","article-title":"Substrate stress relaxation regulates neural stem cell fate commitment","volume":"121","author":"Qiao","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026091814064520900_cit24","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf9758","article-title":"Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing","volume":"10","author":"Huerta-L\u00f3pez","year":"2024","journal-title":"Sci. Adv."},{"issue":"10","key":"2026091814064520900_cit25","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202511538","article-title":"An Opto-Actuated Hydrogel for Cell Mechanoactuation and Real-Time Force Monitoring","volume":"13","author":"Kumar","year":"2026","journal-title":"Adv. Sci."},{"issue":"2","key":"2026091814064520900_cit26","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1152\/physrev.00053.2021","article-title":"Vascular mechanotransduction","volume":"103","author":"Davis","year":"2023","journal-title":"Physiol. Rev."},{"key":"2026091814064520900_cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0514-3","article-title":"Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers","volume":"2","author":"Ellefsen","year":"2019","journal-title":"Commun. Biol."},{"issue":"33","key":"2026091814064520900_cit28","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303369","article-title":"Actomyosin Activity and Piezo1 Activity Synergistically Drive Urinary System Fibroblast Activation","volume":"10","author":"Chen","year":"2023","journal-title":"Adv. Sci."},{"issue":"16","key":"2026091814064520900_cit29","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.263938","article-title":"Piezo1 balances membrane and cortex tension to stabilize intercellular junctions and maintain the epithelial barrier","volume":"138","author":"Javed","year":"2025","journal-title":"J. Cell Sci."},{"issue":"11","key":"2026091814064520900_cit30","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113053","article-title":"TRPV4 Mechanotransduction in Fibrosis","volume":"10","author":"Adapala","year":"2021","journal-title":"Cells"},{"issue":"20","key":"2026091814064520900_cit31","doi-asserted-by":"publisher","first-page":"5867","DOI":"10.1111\/febs.15665","article-title":"TRPV4 integrates matrix mechanosensing with Ca2+ signaling to regulate extracellular matrix remodeling","volume":"288","author":"Ji","year":"2021","journal-title":"FEBS J."},{"issue":"2","key":"2026091814064520900_cit32","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/sj.emboj.7600931","article-title":"TRPM7, a novel regulator of actomyosin contractility and cell adhesion","volume":"25","author":"Clark","year":"2006","journal-title":"EMBO"},{"issue":"11","key":"2026091814064520900_cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113347","article-title":"The calcium channel TRPC6 promotes chemotherapy-induced persistence by regulating integrin alpha6 mRNA splicing","volume":"42","author":"Mukhopadhyay","year":"2023","journal-title":"Cell Rep."},{"issue":"15","key":"2026091814064520900_cit34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2417290122","article-title":"Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia","volume":"122","author":"Charbonier","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"2026091814064520900_cit35","doi-asserted-by":"publisher","first-page":"665","DOI":"10.62347\/WRGW4430","article-title":"Microporous annealed particle hydrogels in cell culture, tissue regeneration, and emerging application in cancer immunotherapy","volume":"15","author":"Wang","year":"2025","journal-title":"Am. J. Cancer Res."},{"issue":"3","key":"2026091814064520900_cit36","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10464","article-title":"Hydrogel viscoelasticity modulates migration and fusion of mesenchymal stem cell spheroids","volume":"8","author":"Wu","year":"2023","journal-title":"Bioeng. Transl. Med."},{"issue":"1","key":"2026091814064520900_cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63854-9","article-title":"Dynamic rigidity changes enable rapid cell migration on soft substrates","volume":"16","author":"Yang","year":"2025","journal-title":"Nat. Commun."},{"key":"2026091814064520900_cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdev.2021.203683","article-title":"Mechanosensitive ion channels in cell migration","volume":"166","author":"Canales Coutino","year":"2021","journal-title":"Cells Dev."},{"issue":"11","key":"2026091814064520900_cit39","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112815","article-title":"Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis","volume":"10","author":"Dombroski","year":"2021","journal-title":"Cells"},{"key":"2026091814064520900_cit40","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo146","article-title":"Force and cell state-dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry","volume":"8","author":"Yao","year":"2022","journal-title":"Sci. Adv."},{"issue":"8","key":"2026091814064520900_cit41","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1016\/j.cub.2025.02.066","article-title":"The activation of INF2 by Piezo1\/Ca2+ is required for mesenchymal to amoeboid transition in confined environments","volume":"35","author":"Kar","year":"2025","journal-title":"Curr. Biol."},{"key":"2026091814064520900_cit42","doi-asserted-by":"publisher","DOI":"10.1038\/srep27903","article-title":"TRPV4 Regulates Breast Cancer Cell Extravasation, Stiffness and Actin Cortex","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"key":"2026091814064520900_cit43","article-title":"A microfluidic assay for the study of cell migration direction reversal under shear flow","volume":"7","author":"Yankaskas","year":"2021","journal-title":"Sci. Adv."},{"issue":"8","key":"2026091814064520900_cit44","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1073\/pnas.1600371113","article-title":"Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation","volume":"113","author":"Chaudhuri","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"2026091814064520900_cit45","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1084\/jem.20150353","article-title":"TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response","volume":"212","author":"Weber","year":"2015","journal-title":"J. Exp. Med."},{"issue":"2","key":"2026091814064520900_cit46","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41580-022-00530-6","article-title":"Mechanisms and roles of podosomes and invadopodia","volume":"24","author":"Linder","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"2026091814064520900_cit47","doi-asserted-by":"publisher","first-page":"5413","DOI":"10.1073\/pnas.0737381100","article-title":"Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics","volume":"100","author":"Lutolf","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"2026091814064520900_cit48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00418-6","article-title":"Matrix degradability controls multicellularity of 3D cell migration","volume":"8","author":"Trappmann","year":"2017","journal-title":"Nat. Commun."},{"issue":"13","key":"2026091814064520900_cit49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2416771122","article-title":"Matrix degradation enhances stress relaxation, regulating cell adhesion and spreading","volume":"122","author":"Narasimhan","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026091814064520900_cit50","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.biomaterials.2016.02.023","article-title":"Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration","volume":"89","author":"Jha","year":"2016","journal-title":"Biomaterials"},{"key":"2026091814064520900_cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60540-8","article-title":"Viscoelastic N-cadherin-like interactions maintain neural progenitor cell stemness within 3D matrices","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"issue":"11","key":"2026091814064520900_cit52","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1021\/acs.nanolett.4c00307","article-title":"Microenvironment with NIR-Controlled ROS and Mechanical Tensions for Manipulating Cell Activities in Wound Healing","volume":"24","author":"Sun","year":"2024","journal-title":"Nano Lett."},{"key":"2026091814064520900_cit53","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1038\/s41556-023-01272-z","article-title":"A mechanosensitive caveolae\u2013invadosome interplay drives matrix remodelling for cancer cell invasion","volume":"25","author":"Monteiro","year":"2023","journal-title":"Nat. Cell Biol."},{"issue":"7999","key":"2026091814064520900_cit54","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/s41586-023-06991-9","article-title":"Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver","volume":"626","author":"Fan","year":"2024","journal-title":"Nature"},{"issue":"4","key":"2026091814064520900_cit55","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.bpj.2020.07.003","article-title":"Increased Stiffness Inhibits Invadopodia Formation and Cell Migration in 3D","volume":"119","author":"Chang","year":"2020","journal-title":"Biophys. J."},{"issue":"2","key":"2026091814064520900_cit56","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201910079","article-title":"Cross-talk between the calcium channel TRPV4 and reactive oxygen species interlocks adhesive and degradative functions of invadosomes","volume":"220","author":"Vellino","year":"2021","journal-title":"J. Cell Biol."},{"issue":"6","key":"2026091814064520900_cit57","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.ceca.2013.09.003","article-title":"TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells","volume":"54","author":"Visser","year":"2013","journal-title":"Cell Calcium"},{"issue":"1","key":"2026091814064520900_cit58","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43768-0","article-title":"Hydrogels with tunable mechanical plasticity regulate endothelial cell outgrowth in vasculogenesis and angiogenesis","volume":"14","author":"Wei","year":"2023","journal-title":"Nat. Commun."},{"issue":"5","key":"2026091814064520900_cit59","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.stem.2020.08.005","article-title":"Hydrogel Network Dynamics Regulate Vascular Morphogenesis","volume":"27","author":"Wei","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"3","key":"2026091814064520900_cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.celbio.2025.100052","article-title":"M2 macrophage coculture overrides viscoelastic hydrogel mechanics to promote fibroblast activation","volume":"1","author":"Astrab","year":"2025","journal-title":"Cell Biomater."},{"key":"2026091814064520900_cit61","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50072-y","article-title":"Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing","volume":"15","author":"Butenko","year":"2024","journal-title":"Nat. Commun."},{"key":"2026091814064520900_cit62","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202500435","article-title":"Hydrogel viscoelasticity modulates cell nascent extracellular matrix deposition","volume":"46","author":"Tan","year":"2025","journal-title":"Macromol. Rapid Commun."},{"issue":"3","key":"2026091814064520900_cit63","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03481-6","article-title":"Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1","volume":"12","author":"He","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"2026091814064520900_cit64","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06466-3","article-title":"Mechanical stiffness promotes skin fibrosis via Piezo1-Wnt2\/Wnt11-CCL24 positive feedback loop","volume":"15","author":"He","year":"2024","journal-title":"Cell Death Dis."},{"key":"2026091814064520900_cit65","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.yjmcc.2012.10.016","article-title":"TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals","volume":"54","author":"Adapala","year":"2013","journal-title":"J. Mol. Cell Cardiol."},{"issue":"3","key":"2026091814064520900_cit66","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.taap.2014.08.006","article-title":"TGF-\u03b21-elevated TRPM7 channel regulates collagen expression in hepatic stellate cells via TGF-\u03b21\/Smad pathway","volume":"280","author":"Li","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"2026091814064520900_cit67","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.bbadis.2016.12.002","article-title":"Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis","volume":"1863","author":"Hofmann","year":"2017","journal-title":"Biochim Biophys Acta. Mol. Basis Dis."},{"key":"2026091814064520900_cit68","doi-asserted-by":"publisher","DOI":"10.1101\/2024.04.14.589442","article-title":"Viscoelastic extracellular matrix enhances epigenetic remodeling and cellular plasticity","volume":"16","author":"Wu","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"2026091814064520900_cit69","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-025-01131-7","article-title":"Effects of hydrogel stiffness and viscoelasticity on organoid culture: a comprehensive review","volume":"31","author":"Lai","year":"2025","journal-title":"Mol Med"},{"key":"2026091814064520900_cit70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/20417314241230","article-title":"Human induced pluripotent stem cell-derived planar neural organoids assembled on synthetic hydrogels","volume":"15","author":"Majumder","year":"2024","journal-title":"J. Tissue Eng."},{"issue":"3","key":"2026091814064520900_cit71","doi-asserted-by":"publisher","DOI":"10.1063\/5.0275439","article-title":"Mechanobiological engineering strategies for organoid culture","volume":"9","author":"Taghizadeh","year":"2025","journal-title":"APL Bioeng."},{"issue":"10","key":"2026091814064520900_cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116308","article-title":"Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state","volume":"44","author":"van der Net","year":"2025","journal-title":"Cell Rep."},{"issue":"22","key":"2026091814064520900_cit73","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.1016\/j.devcel.2025.06.026","article-title":"An extracellular matrix niche secreted by epithelial cells drives intestinal organoid formation","volume":"60","author":"Chrisnandy","year":"2025","journal-title":"Dev. Cell"},{"issue":"1","key":"2026091814064520900_cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2024.11.006","article-title":"Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels","volume":"20","author":"Eiken","year":"2025","journal-title":"Stem Cell Rep."},{"key":"2026091814064520900_cit75","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abh3457","article-title":"The fluid shear stress sensor TRPM7 regulates tumor cell intravasation","volume":"7","author":"Yankaskas","year":"2021","journal-title":"Sci. Adv."},{"key":"2026091814064520900_cit76","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adl4463","article-title":"The role of Piezo1 mechanotransduction in high-grade serous ovarian cancer: Insights from an in vitro model of collective detachment","volume":"10","author":"Micek","year":"2024","journal-title":"Sci. Adv."},{"issue":"2","key":"2026091814064520900_cit77","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202414400","article-title":"Living Cell-Mediated Catalyst-Free Spontaneous Polymerization of Zwitterionic Methacrylates for Preparation of Probiotic-Loaded Hydrogels","volume":"64","author":"Li","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"issue":"18","key":"2026091814064520900_cit78","doi-asserted-by":"publisher","first-page":"7224","DOI":"10.1002\/anie.202001047","article-title":"Solar-Powered Organic Semiconductor-Bacteria Biohybrids for CO2 Reduction into Acetic Acid","volume":"59","author":"Gai","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026091814064520900_cit79","doi-asserted-by":"publisher","DOI":"10.34133\/2022\/9834093","article-title":"Solar-Driven Producing of Value-Added Chemicals with Organic Semiconductor-Bacteria Biohybrid System","volume":"2022","author":"Yu","year":"2022","journal-title":"Research"},{"issue":"7","key":"2026091814064520900_cit80","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.31635\/ccschem.021.202100957","article-title":"Living Bacteria-Mediated Aerobic Photoinduced Radical Polymerization for in Situ Bacterial Encapsulation and Differentiation","volume":"3","author":"Lu","year":"2021","journal-title":"CCS Chem."},{"key":"2026091814064520900_cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtadv.2022.100335","article-title":"Targeting ROS-sensitive TRP ion channels for relieving oxidative stress-related diseases based on nanomaterials","volume":"17","author":"Li","year":"2023","journal-title":"Mater. Today Adv."},{"issue":"43","key":"2026091814064520900_cit82","doi-asserted-by":"publisher","first-page":"48416","DOI":"10.1021\/acsami.2c13322","article-title":"Alleviating Neuroinflammation through Photothermal Conjugated Polymer Nanoparticles by Regulating Reactive Oxygen Species and Ca2+ Signaling","volume":"14","author":"Li","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"8","key":"2026091814064520900_cit83","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202102506","article-title":"Photothermal Conjugated Polymer Nanoparticles for Suppressing Breast Tumor Growth by Regulating TRPA1 Ion Channels","volume":"11","author":"Li","year":"2022","journal-title":"Adv. Healthcare Mater."},{"issue":"19","key":"2026091814064520900_cit84","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202010757","article-title":"Photothermal Modulation of Depression-Related Ion Channel Function through Conjugated Polymer Nanoparticles","volume":"31","author":"Li","year":"2021","journal-title":"Adv. Funct. Mater."},{"issue":"31","key":"2026091814064520900_cit85","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301954","article-title":"NIR-II Regulation of Mitochondrial Potassium Channel with Dual-Targeted Conjugated Oligomer Nanoparticles for Efficient Cancer Theranostics In Vivo","volume":"12","author":"Li","year":"2023","journal-title":"Adv. Healthcare Mater."},{"issue":"3","key":"2026091814064520900_cit86","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202408649","article-title":"Bionanoparticles with In Situ Nitric Oxide Release for Precise Modulation of ER-TRPV1 Ion Channels in Multimodal Killing of Glioblastoma","volume":"21","author":"Li","year":"2025","journal-title":"Small"},{"issue":"20","key":"2026091814064520900_cit87","doi-asserted-by":"publisher","first-page":"23117","DOI":"10.1021\/acsami.1c23146","article-title":"Polymer Nanoparticles Overcome Drug Resistance by a Dual-Targeting Apoptotic Signaling Pathway in Breast Cancer","volume":"14","author":"Li","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"13","key":"2026091814064520900_cit88","doi-asserted-by":"publisher","first-page":"5427","DOI":"10.1021\/acs.nanolett.2c01472","article-title":"Remote Manipulation of ROS-Sensitive Calcium Channel Using Near-Infrared-Responsive Conjugated Oligomer Nanoparticles for Enhanced Tumor Therapy In Vivo","volume":"22","author":"Li","year":"2022","journal-title":"Nano. Lett."},{"issue":"22","key":"2026091814064520900_cit89","doi-asserted-by":"publisher","first-page":"10608","DOI":"10.1021\/acs.nanolett.3c03701","article-title":"Dual Activation of Calcium Channels Using Near-Infrared Responsive Conjugated Oligomer Nanoparticles for Precise Regulation of Blood Glucose Homeostasis","volume":"23","author":"Li","year":"2023","journal-title":"Nano. Lett."}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c06015","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/33\/44700\/66533172\/am-2026-060153.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/33\/44700\/66533172\/am-2026-060153.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:29:16Z","timestamp":1789756156000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/18\/33\/44700\/5254664\/Reciprocal-Coupling-among-Extracellular-Matrix"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":89,"journal-issue":{"issue":"33","published-online":{"date-parts":[[2026,8,13]]},"published-print":{"date-parts":[[2026,8,26]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.6c06015","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]}}}