{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:14:19Z","timestamp":1788473659644,"version":"build-2803163510"},"reference-count":54,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"publisher","award":["2022YFA1105101"],"award-info":[{"award-number":["2022YFA1105101"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The tumor microenvironment (TME) critically regulates cancer progression by providing biochemical and biophysical cues that shape cellular behavior. However, how defined physical microenvironments govern cancer stemness and chemoresistance through mechanotransduction remains poorly understood. Here, we systematically engineered eight tumor-mimetic microenvironments by integrating serum, oxygen, and 3D compacted culture to investigate their effects on A549 non-small cell lung cancer cells. Among all conditions, cells cultured under 3D culture (PM4C) exhibited reduced cellular stiffness, enhanced expression of cancer stemness markers (EpCAM and CD44), and significantly increased resistance to cisplatin in both in vitro and nude mouse xenograft models. Transcriptomic analysis revealed that differentially expressed genes in the PM4C group were predominantly enriched in cell adhesion, mechanotransduction, stemness, and cisplatin resistance pathways. Metabolomic profiling further revealed a substantial accumulation of anaerobic metabolites associated with the maintenance of stemness. Mechanistically, the PM4C microenvironment remodeled matrix production, cell-ECM interactions, and cytoskeletal organization while inducing epigenetic reprogramming (reduced H3K9 acetylation), collectively promoting a stem-like and chemoresistant phenotype. These findings establish a direct mechanistic link between TME and cancer cell stemness, demonstrating that TME can reprogram stemness and drug responsiveness through mechano-epigenetic regulation. This work provides a mechanobiological framework for engineering physiologically relevant tumor organoids and offers new strategies for developing TME-targeted drugs and therapies.<\/jats:p>","DOI":"10.1021\/acsami.6c06355","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:19:57Z","timestamp":1785849597000},"page":"43676-43692","source":"Crossref","is-referenced-by-count":0,"title":["Tumor-Mimetic Microenvironment Primes Cancer Stemness and Drug Resistance through Nucleoskeleton-Mediated Chromatin Remodeling"],"prefix":"10.1021","volume":"18","author":[{"given":"Duoduo","family":"Zhang","sequence":"first","affiliation":[{"name":"Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, China, 325024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Chiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, China, 325024"]},{"name":"Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences , , , ,","place":["Shenzhen, Guangdong, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunchan","family":"Li","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, China, 325024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshan","family":"Xu","sequence":"additional","affiliation":[{"name":"Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences , , , ,","place":["Shenzhen, Guangdong, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, China, 325024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Liu","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, China, 325024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjian","family":"Liu","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, China, 325024"]},{"name":"Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences , , , ,","place":["Shenzhen, Guangdong, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Hua","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, China, 325024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7965-2914","authenticated-orcid":true,"given":"Peng-Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, China, 325024"]},{"name":"Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences , , , ,","place":["Shenzhen, Guangdong, China, 518055"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"issue":"16","key":"2026090317184426400_cit1","doi-asserted-by":"publisher","first-page":"20169","DOI":"10.1021\/acsami.4c00556","article-title":"Interrogating Matrix Stiffness and Metabolomics in Pancreatic Ductal Carcinoma Using an Openable Microfluidic Tumor-on-a-Chip","volume":"16","author":"Mohan","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"36","key":"2026090317184426400_cit2","doi-asserted-by":"publisher","first-page":"32623","DOI":"10.1021\/acsami.9b09337","article-title":"Influence of Hydrolyzed Polyacrylamide Hydrogel Stiffness on Podocyte Morphology, Phenotype, and Mechanical Properties","volume":"11","author":"Abdallah","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"2026090317184426400_cit3","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1021\/acsami.8b19396","article-title":"Cellular Volume and Matrix Stiffness Direct Stem Cell Behavior in a 3D Microniche","volume":"11","author":"Bao","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"42","key":"2026090317184426400_cit4","doi-asserted-by":"publisher","first-page":"47355","DOI":"10.1021\/acsami.0c16478","article-title":"A Hydrogel-Integrated Culture Device to Interrogate T Cell Activation with Physicochemical Cues","volume":"12","author":"Chin","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"20","key":"2026090317184426400_cit5","doi-asserted-by":"publisher","first-page":"22399","DOI":"10.1021\/acsami.9b20939","article-title":"Cell-Cell Adhesion-Driven Contact Guidance and Its Effect on Human Mesenchymal Stem Cell Differentiation","volume":"12","author":"Le Saux","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"2026090317184426400_cit6","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1021\/acsami.9b18425","article-title":"Mechanics-Controlled Dynamic Cell Niches Guided Osteogenic Differentiation of Stem Cells via Preserved Cellular Mechanical Memory","volume":"12","author":"Wei","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"8","key":"2026090317184426400_cit7","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.3390\/polym15081925","article-title":"Engineering Cell Microenvironment Using Nanopattern-Derived Multicellular Spheroids and Photo-Crosslinked Gelatin\/Hyaluronan Hydrogels","volume":"15","author":"Zhang","year":"2023","journal-title":"Polymers"},{"issue":"3","key":"2026090317184426400_cit8","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.biomaterials.2013.10.037","article-title":"The regulation of dynamic mechanical coupling between actin cytoskeleton and nucleus by matrix geometry","volume":"35","author":"Li","year":"2014","journal-title":"Biomaterials"},{"issue":"3","key":"2026090317184426400_cit9","doi-asserted-by":"publisher","DOI":"10.1063\/5.0203570","article-title":"The prognostic effect of mechanical, ultrastructural, and ECM signatures in glioblastoma core and rim","volume":"8","author":"Mahaffey","year":"2024","journal-title":"APL Bioeng."},{"issue":"1","key":"2026090317184426400_cit10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-022-01259-6","article-title":"Targeting integrin pathways: mechanisms and advances in therapy","volume":"8","author":"Pang","year":"2023","journal-title":"Signal Transduction Targeted Ther."},{"issue":"2","key":"2026090317184426400_cit11","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41580-024-00777-1","article-title":"The role and regulation of integrins in cell migration and invasion","volume":"26","author":"Chastney","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026090317184426400_cit12","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1016\/j.bbadis.2018.04.019","article-title":"Acidic pHe regulates cytoskeletal dynamics through conformational integrin \u03b21 activation and promotes membrane protrusion","volume":"1864","author":"Li","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"issue":"1","key":"2026090317184426400_cit13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ceb.2010.10.015","article-title":"Nuclear mechanics during cell migration","volume":"23","author":"Friedl","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"key":"2026090317184426400_cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2023.102218","article-title":"Dynamic links between mechanical forces and metabolism shape the tumor milieu","volume":"84","author":"Bertolio","year":"2023","journal-title":"Curr. Opin. Cell Biol."},{"issue":"6","key":"2026090317184426400_cit15","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1529\/biophysj.108.132274","article-title":"Dynamics of Chromatin Decondensation Reveals the Structural Integrity of a Mechanically Prestressed Nucleus","volume":"95","author":"Mazumder","year":"2008","journal-title":"Biophys. J."},{"issue":"12","key":"2026090317184426400_cit16","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/nrm.2017.101","article-title":"Regulation of genome organization and gene expression by nuclear mechanotransduction","volume":"18","author":"Uhler","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026090317184426400_cit17","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12551-021-00811-y","article-title":"Biophysical interactions between components of the tumor microenvironment promote metastasis","volume":"13","author":"Vasilaki","year":"2021","journal-title":"Biophys. Rev."},{"key":"2026090317184426400_cit18","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.jcis.2020.09.080","article-title":"Effect of laminin, polylysine and cell medium components on the attachment of human hepatocellular carcinoma cells to cellulose nanofibrils analyzed by surface plasmon resonance","volume":"584","author":"Zhang","year":"2021","journal-title":"J. Colloid Interface Sci."},{"issue":"1","key":"2026090317184426400_cit19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40880-018-0288-x","article-title":"Amino acid transporter SLC7A11\/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer","volume":"38","author":"Koppula","year":"2018","journal-title":"Cancer Commun."},{"issue":"21","key":"2026090317184426400_cit20","doi-asserted-by":"publisher","first-page":"4655","DOI":"10.1158\/0008-5472.can-20-1192","article-title":"Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway","volume":"80","author":"Lu","year":"2020","journal-title":"Cancer Res."},{"issue":"1","key":"2026090317184426400_cit21","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s13046-019-1225-9","article-title":"Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells","volume":"38","author":"Hwang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"4","key":"2026090317184426400_cit22","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.3892\/ijo.2017.3877","article-title":"Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells","volume":"50","author":"Hui","year":"2017","journal-title":"Int. J. Oncol."},{"issue":"1","key":"2026090317184426400_cit23","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s43556-026-00430-7","article-title":"Role of autophagy in tumorigenesis and drug resistance: molecular mechanisms and therapeutic targets","volume":"7","author":"Zhu","year":"2026","journal-title":"Mol. Biomed."},{"issue":"4","key":"2026090317184426400_cit24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028203","article-title":"Serum starvation induced cell cycle synchronization facilitates human somatic cells reprogramming","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"issue":"49","key":"2026090317184426400_cit25","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202206688","article-title":"Disruption of Iron Homeostasis to Induce Ferroptosis with Albumin-Encapsulated Pt(IV) Nanodrug for the Treatment of Non-Small Cell Lung Cancer","volume":"19","author":"Tian","year":"2023","journal-title":"Small"},{"issue":"5","key":"2026090317184426400_cit26","doi-asserted-by":"publisher","first-page":"668","DOI":"10.3390\/biom12050668","article-title":"Alanine\u2013Glyoxylate Aminotransferase Sustains Cancer Stemness Properties through the Upregulation of SOX2 and OCT4 in Hepatocellular Carcinoma Cells","volume":"12","author":"Ye","year":"2022","journal-title":"Biomolecules"},{"issue":"41","key":"2026090317184426400_cit27","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1002\/advs.202503851","article-title":"m6A-Modified circRAPGEF1 Interaction with IGF2BP3 Promotes Hepatocellular Carcinoma Progression via Reprogramming Aspartate Metabolism","volume":"12","author":"Shi","year":"2025","journal-title":"Adv. Sci."},{"issue":"14","key":"2026090317184426400_cit28","doi-asserted-by":"publisher","first-page":"6501","DOI":"10.7150\/ijbs.114791","article-title":"Lung Cancer Cell-intrinsic Asparagine Synthetase Potentiates Anti-Tumor Immunity via Modulating Immunogenicity and Facilitating Immune Remodeling in Metastatic Tumor-draining Lymph Nodes","volume":"21","author":"Zhang","year":"2025","journal-title":"Int. J. Biol. Sci."},{"issue":"12","key":"2026090317184426400_cit29","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.7150\/thno.18992","article-title":"Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling","volume":"7","author":"Cao","year":"2017","journal-title":"Theranostics"},{"key":"2026090317184426400_cit30","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12943-017-0623-x","article-title":"Regulation of stem-like cancer cells by glutamine through \u03b2-catenin pathway mediated by redox signaling","volume":"16","author":"Liao","year":"2017","journal-title":"Mol. Cancer"},{"issue":"31","key":"2026090317184426400_cit31","doi-asserted-by":"publisher","first-page":"31151","DOI":"10.18632\/oncotarget.5150","article-title":"Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"issue":"3","key":"2026090317184426400_cit32","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1021\/acs.jproteome.6b00936","article-title":"Head and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde Dehydrogenase","volume":"16","author":"Kamarajan","year":"2017","journal-title":"J. Proteome Res."},{"issue":"22","key":"2026090317184426400_cit33","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.3390\/cells11223607","article-title":"Stemness of Normal and Cancer Cells: The Influence of Methionine Needs and SIRT1\/PGC-1\u03b1\/PPAR-\u03b1 Players","volume":"11","author":"Siblini","year":"2022","journal-title":"Cells"},{"issue":"1","key":"2026090317184426400_cit34","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1186\/s13287-022-02988-9","article-title":"A gene signature is critical for intrahepatic cholangiocarcinoma stem cell self-renewal and chemotherapeutic response","volume":"13","author":"Huang","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"2026090317184426400_cit35","doi-asserted-by":"publisher","first-page":"6672","DOI":"10.1038\/s41467-024-50908-7","article-title":"Epigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer","volume":"15","author":"Cacciatore","year":"2024","journal-title":"Nat. Commun."},{"key":"2026090317184426400_cit36","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1146\/annurev-bioeng-110220-115419","article-title":"Regulation of Tumor Invasion by the Physical Microenvironment: Lessons from Breast and Brain Cancer","volume":"24","author":"Beeghly","year":"2022","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"2026090317184426400_cit37","doi-asserted-by":"publisher","DOI":"10.7554\/elife.58688","article-title":"Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment","volume":"10","author":"Nicolas-Boluda","year":"2021","journal-title":"eLife"},{"issue":"12","key":"2026090317184426400_cit38","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.3390\/biom15121634","article-title":"Biomimetic Salivary Gland Cancer Spheroid Platform for In Vitro Recapitulation of Three-Dimensional Tumor-Stromal Interactions","volume":"15","author":"Wang","year":"2025","journal-title":"Biomolecules"},{"issue":"809","key":"2026090317184426400_cit39","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adn9472","article-title":"AGPAT4 targeted covalent inhibitor potentiates targeted therapy to overcome cancer cell plasticity in hepatocellular carcinoma mouse models","volume":"17","author":"Ng","year":"2025","journal-title":"Sci. Transl. Med."},{"issue":"9","key":"2026090317184426400_cit40","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1007\/s12094-024-03431-6","article-title":"Integrated analysis reveals an aspartate metabolism-related gene signature for predicting the overall survival in patients with hepatocellular carcinoma","volume":"26","author":"Shi","year":"2024","journal-title":"Clin. Transl. Oncol."},{"issue":"9","key":"2026090317184426400_cit41","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1292\/jvms.19-0194","article-title":"Metabolite profiling in sphere-forming cells from canine mammary adenocarcinoma cell lines using gas chromatography-mass spectrometry","volume":"81","author":"Michishita","year":"2019","journal-title":"J. Vet. Med. Sci."},{"key":"2026090317184426400_cit42","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/cac2.12294","article-title":"Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis","volume":"42","author":"Zhou","year":"2022","journal-title":"Cancer Commun."},{"issue":"7069","key":"2026090317184426400_cit43","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/nature04186","article-title":"VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche","volume":"438","author":"Kaplan","year":"2005","journal-title":"Nature"},{"issue":"29","key":"2026090317184426400_cit44","doi-asserted-by":"publisher","first-page":"45702","DOI":"10.18632\/oncotarget.10157","article-title":"Fibrotic microenvironment promotes the metastatic seeding of tumor cells via activating the fibronectin 1\/secreted phosphoprotein 1-integrin signaling","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"issue":"7796","key":"2026090317184426400_cit45","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/s41586-020-1998-1","article-title":"Mechanical regulation of glycolysis via cytoskeleton architecture","volume":"578","author":"Park","year":"2020","journal-title":"Nature"},{"key":"2026090317184426400_cit46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2121816119","article-title":"Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics","volume":"119","author":"Vahabikashi","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"2026090317184426400_cit47","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/s41417-024-00738-y","article-title":"Histone 3 lysine 9 acetylation-specific reprogramming regulates esophageal squamous cell carcinoma progression and metastasis","volume":"31","author":"Chen","year":"2024","journal-title":"Cancer Gene Ther."},{"key":"2026090317184426400_cit48","doi-asserted-by":"publisher","first-page":"6138","DOI":"10.1038\/ncomms7138","article-title":"Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness","volume":"6","author":"Furusawa","year":"2015","journal-title":"Nat. Commun."},{"issue":"3","key":"2026090317184426400_cit49","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30531","article-title":"Mechanotransduction and epigenetic modulations of chromatin: Role of mechanical signals in gene regulation","volume":"125","author":"Mishra","year":"2024","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"2026090317184426400_cit50","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/s41551-020-00657-x","article-title":"Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer","volume":"5","author":"Jang","year":"2021","journal-title":"Nat. Biomed. Eng."},{"issue":"8","key":"2026090317184426400_cit51","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1038\/s41556-020-0548-2","article-title":"Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechanosensitive structures","volume":"22","author":"Massou","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"2026090317184426400_cit52","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1146\/annurev-bioeng-060418-052139","article-title":"The Driving Force: Nuclear Mechanotransduction in Cellular Function, Fate, and Disease","volume":"21","author":"Maurer","year":"2019","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"2026090317184426400_cit53","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/bit.25709","article-title":"Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins","volume":"113","author":"Zustiak","year":"2016","journal-title":"Biotechnol. Bioeng."},{"issue":"4","key":"2026090317184426400_cit54","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1656","article-title":"Tumour organoids and assembloids: Patient-derived cancer avatars for immunotherapy","volume":"14","author":"Mei","year":"2024","journal-title":"Clin. Transl. Med."}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c06355","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/32\/43676\/66334529\/am-2026-06355h.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/32\/43676\/66334529\/am-2026-06355h.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:18:51Z","timestamp":1788470331000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/18\/32\/43676\/5237010\/Tumor-Mimetic-Microenvironment-Primes-Cancer"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":54,"journal-issue":{"issue":"32","published-online":{"date-parts":[[2026,7,30]]},"published-print":{"date-parts":[[2026,8,19]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.6c06355","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}