{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:32:34Z","timestamp":1791293554395,"version":"4.1.0"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"22","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41EB027062"],"award-info":[{"award-number":["P41EB027062"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2026,6,10]]},"DOI":"10.1021\/acsami.6c06529","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T06:29:35Z","timestamp":1779863375000},"page":"31046-31060","source":"Crossref","is-referenced-by-count":2,"title":["Functional Performance of Silk Nanoparticles for Oral Drug Delivery"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0541-7839","authenticated-orcid":true,"given":"Charlotte","family":"Jacobus","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering","place":["Medford, United States"]},{"name":"Tufts University","place":["Medford, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawnaz","family":"Shaidani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Medford, United States"]},{"name":"Tufts University","place":["Medford, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Tonies","sequence":"additional","affiliation":[{"name":"Department of Biology","place":["Medford, United States"]},{"name":"Tufts University","place":["Medford, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riley","family":"Soehnlein","sequence":"additional","affiliation":[{"name":"Department of Community Health","place":["Medford, United States"]},{"name":"Tufts University","place":["Medford, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-6668","authenticated-orcid":true,"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Medford, United States"]},{"name":"Tufts University","place":["Medford, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9245-7774","authenticated-orcid":true,"given":"David L.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Medford, United States"]},{"name":"Tufts University","place":["Medford, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S463354"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v22.i5.10"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.12.009"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.04.009"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2016.1176822"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.01.015"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13416"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2021.1825375"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-021-01025-x"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-018-0728-4"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.08.013"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.10.007"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10143"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00358-0"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-014-2379-1"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.601626"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64464-9"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c00090"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2014.12.029"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.3c03451"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.05.059"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2011.568936"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.6b00457"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","unstructured":"Wongpinyochit, T.; Johnston, B. F.; Seib, F. P. Manufacture and Drug Delivery Applications of Silk Nanoparticles.\n                      J. Vis Exp.\n                      2016, 116 Epub 20161008. 10.3791\/54669 PubMed PMID: 27768078; PMCID: PMC5092179.","DOI":"10.3791\/54669"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c00523"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b01021"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1177\/0148607197021005279"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.5b03634"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.05.069"},{"issue":"3","key":"ref30\/cit30","first-page":"183","volume":"46","author":"Fallingborg J.","year":"1999","journal-title":"Dan Med. Bull."},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37945"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2018.02.032"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/srep13708"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-21-0047"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79992-7"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.07.051"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.04.016"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/bm101422j"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00040-5"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/bip.22026"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1066029"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.2c00639"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42796-0"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.02.027"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/la202267p"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b01003"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1177\/2211068214561025"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2018.10.012"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.11.009"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.11.008"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1218"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(97)00149-X"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.06.028"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.05.002"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1002\/med.21767"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.10.019"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b00175"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-023-00552-2"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm4677"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17121563"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.0c00722"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2012.07.014"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-6411(03)00145-0"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.02.045"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.07.050"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c02403"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0465-5"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.03.043"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13101686"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2018.04.004"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c06529","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c06529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:50:09Z","timestamp":1781081409000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.6c06529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":70,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2026,6,10]]}},"alternative-id":["10.1021\/acsami.6c06529"],"URL":"https:\/\/doi.org\/10.1021\/acsami.6c06529","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]}}}