{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:14:53Z","timestamp":1787163293220,"version":"build-2736575974"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"19","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202617"],"award-info":[{"award-number":["82202617"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272277"],"award-info":[{"award-number":["82272277"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302585"],"award-info":[{"award-number":["82302585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82530073"],"award-info":[{"award-number":["82530073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82561128249"],"award-info":[{"award-number":["82561128249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0509900"],"award-info":[{"award-number":["2023ZD0509900"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0509904"],"award-info":[{"award-number":["2023ZD0509904"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Scientific and Technological Innovation Projects of Hubei Province","award":["2025BCB005"],"award-info":[{"award-number":["2025BCB005"]}]},{"name":"Major Scientific and Technological Innovation Projects of Hubei Province","award":["2025BCB128"],"award-info":[{"award-number":["2025BCB128"]}]},{"name":"Wuhan Natural Science Foundation Exploration Program","award":["2024040801020348"],"award-info":[{"award-number":["2024040801020348"]}]},{"name":"Huazhong University of Science and Technology Interdisciplinary Research Support Program","award":["2025JCYJ052"],"award-info":[{"award-number":["2025JCYJ052"]}]},{"name":"Major Scientific and Technological Innovation Projects of Wuhan","award":["2025020602030088"],"award-info":[{"award-number":["2025020602030088"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2026,5,20]]},"DOI":"10.1021\/acsami.6c06670","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:31:26Z","timestamp":1777912286000},"page":"27395-27411","source":"Crossref","is-referenced-by-count":1,"title":["Meloxicam-1-\n                    <scp>d<\/scp>\n                    -MT Dual-Drug Hydrogel Serves as an Immunomodulator to Reverse Tumor Postoperative Recurrence and Metastasis"],"prefix":"10.1021","volume":"18","author":[{"given":"Xiaoqiong","family":"Li","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Hubei Clinical Research Center of Minimally Invasive Surgery","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy, Ministry of Education","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunruo","family":"Xu","sequence":"additional","affiliation":[{"name":"The Department of Laboratory Medicine at Wuhan No. 4 Hospital","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luming","family":"Xu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy, Ministry of Education","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Department of Clinical Laboratory, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilin","family":"Li","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy, Ministry of Education","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Department of Clinical Laboratory, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Hubei Clinical Research Center of Minimally Invasive Surgery","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy, Ministry of Education","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Wei","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy, Ministry of Education","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Department of Clinical Laboratory, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyu","family":"Li","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy, Ministry of Education","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Department of Clinical Laboratory, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5716-6587","authenticated-orcid":true,"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy, Ministry of Education","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Department of Clinical Laboratory, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9330-0728","authenticated-orcid":true,"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Hubei Clinical Research Center of Minimally Invasive Surgery","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy, Ministry of Education","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.01.006"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.194"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-015-1740-2"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00185.2020"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1700"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180629111227"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.05.016"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1815"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.015"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1515\/bmc-2018-0007"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1126\/science.adl2016"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03554-w"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01185"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0175-7"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.6.3.321"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.4.2061"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199651030-00007"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-022-00514-1"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(99)00367-8"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-00843-7"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120388"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.42.1241"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201800785"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c17017"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c00124"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.05.114"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/mp300169c"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM01403F"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-18-0196"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5957-x"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S222694"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2011.01196.x"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2022.06.011"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110451"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0360-1"},{"issue":"6","key":"ref36\/cit36","first-page":"2353","volume":"12","author":"An J.","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1612920114"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-2627"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.01.002"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2022.102461"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13484-8"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.02.009"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29121-x"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.08.028"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2023.03.006"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111333"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127143"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c06670","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c06670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:43:21Z","timestamp":1779266601000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.6c06670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":47,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,5,20]]}},"alternative-id":["10.1021\/acsami.6c06670"],"URL":"https:\/\/doi.org\/10.1021\/acsami.6c06670","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]}}}