{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:04:30Z","timestamp":1789506270889,"version":"build-2803163510"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172126"],"award-info":[{"award-number":["82172126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute lung injury\/acute respiratory distress syndrome (ALI\/ARDS) is an acute, life-threatening form of pulmonary disease characterized by systemic inflammation, for which current treatments are not sufficiently effective. Platelet-derived exosomes (PLT-exos) are noted for their specific targeting ability to inflammatory sites, minimal immunogenicity, and positive anti-inflammatory effects, positioning them as a promising therapeutic candidate. However, the specific effects and mechanisms of PLT-exos in ALI\/ARDS remain poorly understood. Here, utilizing a lipopolysaccharide (LPS)-induced ALI model in murine and cell models, we first demonstrated that activated platelet-derived exosomes (AP-exos) are preferentially taken up by lung macrophages, leading to suppressed macrophage M1 polarization and PANoptosis and reduced lung inflammation and injury, which were closely linked to the inhibition of MAPK pathway activity. Mechanistically, the protective effects of AP-exos were partially mediated by the highly enriched miR-142-3p, as evidenced by the intervention with miR-142-3p significantly inhibiting their protective effect against LPS-induced ALI injury in mice. Furthermore, we noted a negative correlation between the level of miR-142-3p derived from plasma exosomes and the severity of ARDS, suggesting its potential in predicting the severity of ARDS. Further investigation revealed that TMEM120B (T120B) functions as a downstream target of miR-142-3p. Overall, the findings suggested that activated platelets release exosomes that inhibit macrophage M1 polarization and PANoptosis, contributing to the pathogenesis of ARDS via the miR-142-3p\/T120B\/MAPK axis.<\/jats:p>","DOI":"10.1021\/acsami.6c06883","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:07:02Z","timestamp":1785931622000},"page":"47269-47289","source":"Crossref","is-referenced-by-count":0,"title":["Platelet-Derived Exosomal miR-142-3p Inhibits Macrophage M1 Polarization and PANoptosis to Alleviate Acute Lung Injury via the MAPK Pathway"],"prefix":"10.1021","volume":"18","author":[{"given":"Man","family":"Zhao","sequence":"first","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanzhao","family":"He","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Health Service and Transfusion Medicine , ,","place":["Beijing, China, 100850"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirui","family":"Xu","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senhao","family":"Wei","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanfeng","family":"Jin","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"First Medical Center of Chinese PLA General Hospital , , ,","place":["Beijing, China, 100853"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Leng","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2068-6217","authenticated-orcid":true,"given":"Qinggang","family":"Ge","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"issue":"8","key":"2026091516065474300_cit1","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1001\/jama.2016.0291","article-title":"Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries","volume":"315","author":"Bellani","year":"2016","journal-title":"JAMA"},{"issue":"11\u201312","key":"2026091516065474300_cit2","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1007\/s10495-025-02168-z","article-title":"Targeting PANoptosis: a promising therapeutic strategy for ALI\/ARDS","volume":"30","author":"Zhang","year":"2025","journal-title":"Apoptosis"},{"issue":"1","key":"2026091516065474300_cit3","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12967-023-04027-4","article-title":"TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury","volume":"21","author":"Zhong","year":"2023","journal-title":"J. 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