{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:01:55Z","timestamp":1786114915119,"version":"build-2736575974"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Burn wounds are highly susceptible to bacterial colonization, particularly by multidrug-resistant pathogens, which often result in refractory infections, excessive inflammation, and delayed healing. Herein, we report the rational design and construction of a multifunctional nano-antimicrobial agent, designated mPB@PHMB, through the co-assembly of mesoporous Prussian blue (mPB) with the polymer polyhexamethylene biguanide (PHMB). The resultant nanocomposite integrates potent antibacterial activity with the capacity to modulate the inflammatory microenvironment. Notably, mPB@PHMB exhibited pronounced bactericidal efficacy against methicillin-resistant Staphylococcus aureus (MRSA). Benefiting from the intrinsic multi-enzyme-mimetic activities of mPB, the nanocomposite efficiently scavenged intracellular reactive oxygen species, thereby alleviating oxidative stress-induced cellular injury. Transcriptomic profiling and protein analyses revealed that mPB@PHMB markedly suppressed the NF-\u03baB pathway activation, attenuated lipopolysaccharide-induced M1 macrophage polarization, and reduced the production of pro-inflammatory cytokines. Biocompatibility assessments demonstrated negligible acute cytotoxicity toward skin fibroblasts and no overt toxicity in healthy C57BL\/6 mice, underscoring the favorable safety profile of mPB@PHMB. Furthermore, in a murine model of MRSA-infected burn wounds, topical treatment with mPB@PHMB reduced the bacterial burden by approximately 90%. Concurrently, treatment with mPB@PHMB substantially decreased the proportion of M1-polarized macrophages, suppressed the expression of inflammatory cytokines, and alleviated the inflammatory milieu within the wound bed, thereby accelerating tissue repair and wound closure. Collectively, these findings establish mPB@PHMB as a promising nano-therapeutic platform that synergistically couples antimicrobial action with immunomodulatory functions, offering a robust and translatable strategy for the management of burn wounds complicated by multidrug-resistant bacterial infection.<\/jats:p>","DOI":"10.1021\/acsami.6c07159","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T17:10:18Z","timestamp":1783962618000},"page":"40273-40290","source":"Crossref","is-referenced-by-count":0,"title":["Construction of an Infection-Inflammation Microenvironment-Regulating Nano-antimicrobial Agent and Application in the Treatment of Burn Wounds Complicated with Multidrug-Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    Infection"],"prefix":"10.1021","volume":"18","author":[{"given":"Huifeng","family":"Qian","sequence":"first","affiliation":[{"name":"Shaoxing Second Hospital , , , ,","place":["Shaoxing, Zhejiang, China, 312000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Pan","sequence":"additional","affiliation":[{"name":"Fujian Medical University , , ,","place":["Fuzhou, China, 350000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Liang","sequence":"additional","affiliation":[{"name":"Shaoxing Second Hospital , , , ,","place":["Shaoxing, Zhejiang, China, 312000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Shaoxing Second Hospital , , , ,","place":["Shaoxing, Zhejiang, China, 312000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debao","family":"Yu","sequence":"additional","affiliation":[{"name":"Shaoxing People's Hospital , , , ,","place":["Shaoxing, Zhejiang, China, 312000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyun","family":"Lu","sequence":"additional","affiliation":[{"name":"Shaoxing Second Hospital , , , ,","place":["Shaoxing, Zhejiang, China, 312000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunchang","family":"Li","sequence":"additional","affiliation":[{"name":"Shaoxing Second Hospital , , , ,","place":["Shaoxing, Zhejiang, China, 312000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Jin","sequence":"additional","affiliation":[{"name":"Shaoxing Second Hospital , , , ,","place":["Shaoxing, Zhejiang, China, 312000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijiang","family":"Tong","sequence":"additional","affiliation":[{"name":"Shaoxing Second Hospital , , , ,","place":["Shaoxing, Zhejiang, China, 312000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4301-5192","authenticated-orcid":true,"given":"Zhangsen","family":"Yu","sequence":"additional","affiliation":[{"name":"Shaoxing University , , , ,","place":["Shaoxing, Zhejiang, China, 312000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"issue":"1","key":"2026080518084485400_cit1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat. 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