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Inspired by the structural and functional attributes of native skin, we designed a dynamic bond-crosslinked, injectable, and in situ-forming polyurethane\/hyaluronic acid-based hybrid hydrogel (PUS-OHABE). In this hydrogel, caffeic acid phenethyl ester (CAPE) was grafted onto aldehyde-modified hyaluronic acid (HA) chains through dynamic borate ester bonds. This CAPE-modified HA was then combined with a side-chain hydrazide (ADH)-modified waterborne polyurethane emulsion via Schiff base reactions to form a stable hydrogel network structure. The PUS-OHABE hydrogel exhibits good self-healing ability, stability, tissue adhesion, and hemostatic capacity. Additionally, it has a unique ability to dissociate borate ester bonds in the hyperglycemic wound microenvironment to responsively release CAPE, thereby conferring antioxidant and anti-inflammatory properties. In diabetic rat models, the PUS-OHABE hydrogel enabled rapid wound healing and re-epithelialization; meanwhile, it also promoted angiogenesis, hair follicle regeneration, and extracellular matrix remodeling, thus offering a promising strategy for the design of biomaterials targeting chronic wound healing.<\/jats:p>","DOI":"10.1021\/acsami.6c07327","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:02:43Z","timestamp":1790654563000},"page":"54364-54383","source":"Crossref","is-referenced-by-count":0,"title":["An Injectable Polyurethane\/Hyaluronic Acid Hybrid Hydrogel for Glucose-Responsive CAPE Release and Immune Remodeling in Diabetic Wound Healing"],"prefix":"10.1021","volume":"18","author":[{"given":"Shunlan","family":"Chen","sequence":"first","affiliation":[{"name":"Sichuan University , , ,","place":["Chengdu, P. R. 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