{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:05:03Z","timestamp":1789506303506,"version":"build-2803163510"},"reference-count":58,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024AFB196"],"award-info":[{"award-number":["2024AFB196"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2042022kf1076"],"award-info":[{"award-number":["2042022kf1076"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bone defects and bone infections remain significant challenges in orthopedics. Effective treatment strategies for bone defects and infectious osteolysis are currently lacking. Although tissue engineering techniques have shown great potential for bone regeneration, their divergence from the physiological microenvironment limits their ability to support endogenous osteogenesis. Herein, we explored the preliminary developmental bone-like bioassemblies aimed at enhancing rapid bone regeneration and serving as a research model for infectious osteolysis. Using a 3D microarray, osteoblast precursor cells were assembled, aggregated, proliferated, and differentiated with ascorbic acid-2-phosphate, \u03b2-glycerophosphate, and dexamethasone, partially recapitulating the structural and functional characteristics of native bone tissue. In vitro assessments showed significant osteogenic differentiation and excellent mineralization properties. In vivo experiments demonstrated the effectiveness of these bioassemblies in promoting bone healing in critical-sized defects, with improved integration into host tissue. Notably, exposure to Staphylococcus aureus PAMPs induced infectious osteolysis in the bone-like bioassemblies, demonstrating their response to pathogenic stimuli and showcasing their potential as a platform for studying bone infection dynamics and host\u2013pathogen interactions. These preliminary developmental bone-like bioassemblies therefore represent a promising strategy for advancing therapeutic approaches in bone regeneration and examining the complexities of infectious processes affecting bone integrity.<\/jats:p>","DOI":"10.1021\/acsami.6c07350","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:02:09Z","timestamp":1786474929000},"page":"47290-47307","source":"Crossref","is-referenced-by-count":0,"title":["Preliminary Developmental Bone-like Bioassemblies for Rapid Bone Regeneration and as an Infectious Osteolysis Research Model"],"prefix":"10.1021","volume":"18","author":[{"given":"Yikai","family":"Wang","sequence":"first","affiliation":[{"name":"Renmin Hospital of Wuhan University , , Jiefang Road 238 , ,","place":["Wuhan, P.R. China, 430060"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University , , Jiefang Road 238 , ,","place":["Wuhan, P.R. China, 430060"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Jin","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University , , Jiefang Road 238 , ,","place":["Wuhan, P.R. China, 430060"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Chen","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University , , Jiefang Road 238 , ,","place":["Wuhan, P.R. China, 430060"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiwen","family":"Huang","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University , , Jiefang Road 238 , ,","place":["Wuhan, P.R. China, 430060"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Ye","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University , , Jiefang Road 238 , ,","place":["Wuhan, P.R. China, 430060"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University , , Jiefang Road 238 , ,","place":["Wuhan, P.R. China, 430060"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juchuan","family":"Jia","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University , , Jiefang Road 238 , ,","place":["Wuhan, P.R. China, 430060"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Cao","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University , , Jiefang Road 238 , ,","place":["Wuhan, P.R. China, 430060"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Yu","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine , , ,","place":["Hangzhou, P.R. China, 310000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoming","family":"Ye","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine , , ,","place":["Hangzhou, P.R. China, 310000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8332-0664","authenticated-orcid":true,"given":"Yijun","family":"Ren","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University , , Jiefang Road 238 , ,","place":["Wuhan, P.R. China, 430060"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"issue":"5","key":"2026091516064961200_cit1","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/s41580-022-00568-6","article-title":"Regulation of Adult Stem Cell Quiescence and Its Functions in the Maintenance of Tissue Integrity","volume":"24","author":"Morree","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"2026091516064961200_cit2","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1038\/s41551-025-01419-3","article-title":"Jawbone-like Organoids Generated from Human Pluripotent Stem Cells","volume":"9","author":"Motoike","year":"2025","journal-title":"Nat. Biomed. Eng."},{"issue":"1","key":"2026091516064961200_cit3","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/s41368-025-00411-6","article-title":"Defining Subcellular Synovial Responses in TMJ Osteoarthritis Onset via Mechanical Stress and Articular Disk Derangement Models","volume":"18","author":"Shibusaka","year":"2026","journal-title":"Int. J. Oral Sci."},{"key":"2026091516064961200_cit4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/s41422-025-01202-8","article-title":"Fibrous-Layer Resident Angptl7+ Periosteal Stem Cells Sense Injury Inflammation to Orchestrate Fracture Repair","volume":"36","author":"Jiang","year":"2026","journal-title":"Cell Res."},{"issue":"39","key":"2026091516064961200_cit5","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202500657","article-title":"Remote-Controlled Magnetic Stimulation of Cell-Based Bioengineered Tissues for In Situ Bone Regeneration","volume":"37","author":"Santos","year":"2025","journal-title":"Adv. Mater."},{"issue":"2","key":"2026091516064961200_cit6","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202514419","article-title":"Temporal Immunomodulatory Hydrogel Regulating the Immune-Osteogenic Cascade for Infected Bone Defects Regeneration","volume":"38","author":"Jin","year":"2026","journal-title":"Adv. Mater."},{"issue":"7","key":"2026091516064961200_cit7","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202303506","article-title":"Enhanced Osteolysis Targeted Therapy through Fusion of Exosomes Derived from M2 Macrophages and Bone Marrow Mesenchymal Stem Cells: Modulating Macrophage Polarization","volume":"20","author":"Ma","year":"2024","journal-title":"Small"},{"key":"2026091516064961200_cit8","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev-pathmechdis-031521-040919","article-title":"Osteoclasts, Master Sculptors of Bone","volume":"18","author":"Veis","year":"2023","journal-title":"Annu. Rev. Pathol.: Mech. Dis."},{"issue":"9","key":"2026091516064961200_cit9","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202766","article-title":"Bone Tissue Engineering Scaffolds: Function of Multi-Material Hierarchically Structured Scaffolds","volume":"12","author":"Koushik","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"11","key":"2026091516064961200_cit10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tibtech.2024.05.006","article-title":"Drug Delivery Strategies through 3D-Printed Calcium Phosphate","volume":"42","author":"Chaudhari","year":"2024","journal-title":"Trends Biotechnol."},{"key":"2026091516064961200_cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123709","article-title":"Emerging Technologies for Personalised Oro-Maxillofacial Bone Regeneration: Design Strategies and Fabrication Techniques","volume":"326","author":"Guo","year":"2025","journal-title":"Biomaterials"},{"issue":"April","key":"2026091516064961200_cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122111","article-title":"Biophysical Cues of Bone Marrow-Inspired Scaffolds Regulate Hematopoiesis of Hematopoietic Stem and Progenitor Cells","volume":"298","author":"Li","year":"2023","journal-title":"Biomaterials"},{"key":"2026091516064961200_cit13","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202514752","article-title":"Intra-Articular Injectable Hydrogel Microsphere-Based Drug Delivery System for Osteoarthritis Treatment","volume":"22","author":"Zhang","year":"2026","journal-title":"Small"},{"issue":"30","key":"2026091516064961200_cit14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/adma.202309875","article-title":"Engineering Large-Scale Self-Mineralizing Bone Organoids with Bone Matrix-Inspired Hydroxyapatite Hybrid Bioinks","volume":"36","author":"Wang","year":"2024","journal-title":"Adv. Mater."},{"key":"2026091516064961200_cit15","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.jare.2025.06.067","article-title":"Engineering Polyphenol-Based Osteogenic System for Bone and Cartilage Repair: Transplantation, Tissue Engineering, and Organoid","volume":"82","author":"Wang","year":"2025","journal-title":"J. Adv. Res."},{"key":"2026091516064961200_cit16","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/s41573-025-01317-y","article-title":"Human Organoids as 3D in Vitro Platforms for Drug Discovery: Opportunities and Challenges","volume":"25","author":"Wang","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"2026091516064961200_cit17","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/s41580-026-00974-0","article-title":"New Developments and Applications of Human Organoids","volume":"27","author":"Andersson-Rolf","year":"2026","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"17","key":"2026091516064961200_cit18","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202010524","article-title":"An Organoid for Woven Bone","volume":"31","author":"Akiva","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"2026091516064961200_cit19","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.bioactmat.2022.01.048","article-title":"The Horizon of Bone Organoid: A Perspective on Construction and Application","volume":"18","author":"Chen","year":"2022","journal-title":"Bioact. Mater."},{"issue":"5","key":"2026091516064961200_cit20","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302088","article-title":"Bone Organoids: Recent Advances and Future Challenges","volume":"13","author":"Zhao","year":"2024","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"2026091516064961200_cit21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40779-022-00426-8","article-title":"The Role of the Immune Microenvironment in Bone, Cartilage, and Soft Tissue Regeneration: From Mechanism to Therapeutic Opportunity","volume":"9","author":"Xiong","year":"2022","journal-title":"Mil. Med. Res."},{"issue":"12","key":"2026091516064961200_cit22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells12121590","article-title":"Organoids as Innovative Models for Bone and Joint Diseases","volume":"12","author":"Huang","year":"2023","journal-title":"Cells"},{"key":"2026091516064961200_cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122100","article-title":"Osteogenesis, Hemocompatibility, and Foreign Body Response of Polyvinylidene Difluoride-Based Composite Reinforced with Carbonaceous Filler and Higher Volume of Piezoelectric Ceramic Phase","volume":"297","author":"Bhaskar","year":"2023","journal-title":"Biomaterials"},{"issue":"6","key":"2026091516064961200_cit24","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12450","article-title":"The Na+\/Ca2+ Exchanger NCX3 Mediates Ca2+ Entry into Matrix Vesicles to Facilitate Initial Steps of Mineralization in Osteoblasts","volume":"13","author":"Sheikh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"2026091516064961200_cit25","doi-asserted-by":"publisher","first-page":"36011","DOI":"10.1038\/srep36011","article-title":"Bioinspired Seeding of Biomaterials Using Three Dimensional Microtissues Induces Chondrogenic Stem Cell Differentiation and Cartilage Formation under Growth Factor Free Conditions","volume":"6","author":"Leijten","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"2026091516064961200_cit26","doi-asserted-by":"publisher","first-page":"6648","DOI":"10.1038\/s41467-022-34352-z","article-title":"Osteocytes Directly Regulate Osteolysis via MYD88 Signaling in Bacterial Bone Infection","volume":"13","author":"Yoshimoto","year":"2022","journal-title":"Nat. Commun."},{"key":"2026091516064961200_cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2025.156451","article-title":"Emerging Roles of Arginine Metabolism in Skeletal Health and Disease","volume":"75","author":"Wang","year":"2026","journal-title":"Metab., Clin. Exp."},{"issue":"March","key":"2026091516064961200_cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105626","article-title":"Mimicking Bone Microenvironment: 2D and 3D in Vitro Models of Human Osteoblasts","volume":"169","author":"Yuste","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"37","key":"2026091516064961200_cit29","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.bioactmat.2024.02.003","article-title":"Extracellular Matrix Stiffness as an Energy Metabolism Regulator Drives Osteogenic Differentiation in Mesenchymal Stem Cells","volume":"35","author":"Na","year":"2024","journal-title":"Bioact. Mater."},{"issue":"24","key":"2026091516064961200_cit30","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202209769","article-title":"Manipulation of Heterogeneous Surface Electric Potential Promotes Osteogenesis by Strengthening RGD Peptide Binding and Cellular Mechanosensing","volume":"35","author":"Bai","year":"2023","journal-title":"Adv. Mater."},{"issue":"28","key":"2026091516064961200_cit31","doi-asserted-by":"publisher","first-page":"15218","DOI":"10.1021\/jacs.3c02210","article-title":"Biomimetic Nanofibrillar Hydrogel with Cell-Adaptable Network for Enhancing Cellular Mechanotransduction, Metabolic Energetics, and Bone Regeneration","volume":"145","author":"Xie","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"7","key":"2026091516064961200_cit32","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41574-024-00969-x","article-title":"Metabolic Regulation of Skeletal Cell Fate and Function","volume":"20","author":"Stegen","year":"2024","journal-title":"Nat. Rev. Endocrinol."},{"key":"2026091516064961200_cit33","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41421-024-00689-6","article-title":"Cell Signaling and Transcriptional Regulation of Osteoblast Lineage Commitment, Differentiation, Bone Formation, and Homeostasis","volume":"10","author":"Zhu","year":"2024","journal-title":"Cell Discov."},{"issue":"1","key":"2026091516064961200_cit34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-023-41349-9","article-title":"Multimodal Spatiotemporal Transcriptomic Resolution of Embryonic Palate Osteogenesis","volume":"14","author":"Pi\u00f1a","year":"2023","journal-title":"Nat. Commun."},{"key":"2026091516064961200_cit35","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202510848","article-title":"Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics","volume":"38","author":"Wang","year":"2026","journal-title":"Adv. Mater."},{"issue":"10","key":"2026091516064961200_cit36","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202208781","article-title":"Stem Cell Membrane-Coated Microribbon Scaffolds Induce Regenerative Innate and Adaptive Immune Responses in a Critical-Size Cranial Bone Defect Model","volume":"35","author":"Su","year":"2023","journal-title":"Adv. Mater."},{"key":"2026091516064961200_cit37","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202512392","article-title":"Biomimetic Multifunctional Scaffolds for Osteochondral Regeneration: Bridging Material Design and Functional Integration","volume":"22","author":"Zhong","year":"2026","journal-title":"Small"},{"key":"2026091516064961200_cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2026.103139","article-title":"Age-Associated Regulation of Chondrocyte Hypertrophy in Osteoarthritis: Mechanisms, Therapeutic Implications, and Cartilage Fate Reprogramming","volume":"118","author":"Ha","year":"2026","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"2026091516064961200_cit39","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/prd.12517","article-title":"Optimized Bone Grafting","volume":"94","author":"Miron","year":"2024","journal-title":"Periodontol. 2000"},{"issue":"1","key":"2026091516064961200_cit40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13045-022-01284-6","article-title":"Worked to the Bone: Antibody-Based Conditioning as the Future of Transplant Biology","volume":"15","author":"Griffin","year":"2022","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"2026091516064961200_cit41","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add1541","article-title":"A BMP-2\u2013Triggered in Vivo Osteo-Organoid for Cell Therapy","volume":"9","author":"Dai","year":"2023","journal-title":"Sci. Adv."},{"issue":"1","key":"2026091516064961200_cit42","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41526-021-00146-8","article-title":"Trabecular Bone Organoids: A Micron-Scale \u2018Humanised\u2019 Prototype Designed to Study the Effects of Microgravity and Degeneration","volume":"7","author":"Iordachescu","year":"2021","journal-title":"NPJ Microgravity"},{"issue":"10514","key":"2026091516064961200_cit43","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1016\/S0140-6736(25)01385-6","article-title":"Osteoporosis","volume":"406","author":"Ye","year":"2025","journal-title":"Lancet"},{"issue":"2","key":"2026091516064961200_cit44","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1158\/2159-8290.CD-22-0199","article-title":"Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies","volume":"13","author":"Khan","year":"2023","journal-title":"Cancer Discov."},{"issue":"5","key":"2026091516064961200_cit45","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3390\/genes9050247","article-title":"Journey into Bone Models: A Review","volume":"9","author":"Scheinpflug","year":"2018","journal-title":"Genes (Basel)"},{"issue":"7","key":"2026091516064961200_cit46","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1021\/acscentsci.3c00499","article-title":"Repurposed Fenoprofen Targeting SaeR Attenuates Staphylococcus aureus Virulence in Implant-Associated Infections","volume":"9","author":"Jiang","year":"2023","journal-title":"ACS Cent. Sci."},{"key":"2026091516064961200_cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106400","article-title":"Alpinetin Ameliorates Bone Loss in LPS-Induced Inflammation Osteolysis via ROS Mediated P38\/PI3K Signaling Pathway","volume":"184","author":"Wei","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"1","key":"2026091516064961200_cit48","doi-asserted-by":"publisher","DOI":"10.1002\/smmd.20230028","article-title":"Modeling, Applications and Challenges of Inner Ear Organoid","volume":"3","author":"Qi","year":"2024","journal-title":"Smart Med."},{"key":"2026091516064961200_cit49","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.bioactmat.2025.12.018","article-title":"Nanocatalytic Magnesium Osteoimplants with Biodegradable Self-Adaptive Interfaces for Therapeutic Repair of Infected Bone Defects","volume":"58","author":"Wu","year":"2026","journal-title":"Bioact. Mater."},{"key":"2026091516064961200_cit50","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41413-024-00362-4","article-title":"Mapping RANKL- and OPG-Expressing Cells in Bone Tissue: The Bone Surface Cells as Activators of Osteoclastogenesis and Promoters of the Denosumab Rebound Effect (Accepted for Publication in Bone Research, August 1st, 2024)","volume":"12","author":"El-Masri","year":"2024","journal-title":"Bone Res."},{"issue":"1","key":"2026091516064961200_cit51","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41413-020-00106-0","article-title":"BMP-Induced Atoh8 Attenuates Osteoclastogenesis by Suppressing Runx2 Transcriptional Activity and Reducing the Rankl\/Opg Expression Ratio in Osteoblasts","volume":"8","author":"Yahiro","year":"2020","journal-title":"Bone Res."},{"key":"2026091516064961200_cit52","doi-asserted-by":"publisher","DOI":"10.1111\/prd.70011","article-title":"Antibiotic-Mediated Immune Modulation in Periodontitis","author":"Su\u00e1rez","year":"2025","journal-title":"Periodontol. 2000"},{"issue":"1","key":"2026091516064961200_cit53","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41421-025-00853-6","article-title":"Cell Signaling and Transcriptional Regulation of Osteoclast Lineage Commitment, Differentiation, Bone Resorption and Diseases","volume":"12","author":"Zhu","year":"2026","journal-title":"Cell Discov."},{"key":"2026091516064961200_cit54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41413-025-00478-1","article-title":"Inflammatory Bone Loss and Signaling Pathways in Periodontitis: Mechanistic Insights and Emerging Therapeutic Strategies","volume":"14","author":"de Molon","year":"2026","journal-title":"Bone Res."},{"issue":"1","key":"2026091516064961200_cit55","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41413-023-00287-4","article-title":"Evidence of Bisphosphonate-Conjugated Sitafloxacin Eradication of Established Methicillin-Resistant S. Aureus Infection with Osseointegration in Murine Models of Implant-Associated Osteomyelitis","volume":"11","author":"Ren","year":"2023","journal-title":"Bone Res."},{"issue":"7","key":"2026091516064961200_cit56","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1038\/s41596-024-00971-7","article-title":"Generating Human Bone Marrow Organoids for Disease Modeling and Drug Discovery","volume":"19","author":"Olijnik","year":"2024","journal-title":"Nat. Protoc."},{"issue":"1","key":"2026091516064961200_cit57","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/s41413-026-00543-3","article-title":"From Complexity to Clarity: Aging Bone Marrow Niche in Bone and Blood Regeneration and Malignancy","volume":"14","author":"Roy","year":"2026","journal-title":"Bone Res."},{"issue":"1","key":"2026091516064961200_cit58","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41392-025-02556-6","article-title":"Osteoarthritis: Molecular Pathogenesis and Potential Therapeutic Options","volume":"11","author":"Zhang","year":"2026","journal-title":"Signal Transduct. Target. Ther."}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c07350","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/35\/47290\/66501341\/am-2026-07350g.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/35\/47290\/66501341\/am-2026-07350g.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:12:37Z","timestamp":1789503157000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/18\/35\/47290\/5252840\/Preliminary-Developmental-Bone-like-Bioassemblies"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":58,"journal-issue":{"issue":"35","published-online":{"date-parts":[[2026,8,11]]},"published-print":{"date-parts":[[2026,9,9]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.6c07350","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]}}}