{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:46:29Z","timestamp":1792784789410,"version":"4.5.0"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Province Traditional Chinese Medicine Science & Technology Project"},{"name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Distinguished Taishan Scholars Program"},{"name":"Jinan New Support Projects for Universities"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Methicillin-resistant Staphylococcus aureus (MRSA) and its biofilms severely impair wound healing, necessitating therapies that integrate antibacterial activity with tissue repair functions. In this study, we developed a carrier-free injectable supramolecular hydrogel, referred to as the GB gel, through the co-assembly of two natural small molecules, glycyrrhizic acid (GA) and baicalin (BA). The principal design logic of this system lies in the cooperative integration of GA-mediated amphiphilic assembly and BA-mediated antibacterial activity: GA improves the aqueous solubility of BA, drives nanoparticle formation, and facilitates bacterial membrane adsorption and disruption, whereas BA serves as the major bactericidal component. The optimized GB gel exhibited favorable injectability, self-healing behavior, and sustained-release properties. In vitro, the GB gel showed potent anti-MRSA and antibiofilm effects, accompanied by bacterial membrane disruption, increased intracellular reactive oxygen species, and apoptosis-like responses. In a murine MRSA-infected wound model, topical GB gel application accelerated wound closure, reduced bacterial burden, alleviated inflammation, and promoted neovascularization and collagen deposition. Network pharmacology and transcriptomic analyses further suggested that GB gel treatment was associated with broad stress-responsive transcriptional reprogramming in MRSA, involving translation-related processes, central metabolic pathways, and host immune-related regulatory networks. Overall, this carrier-free GA\/BA co-assembled hydrogel integrates antibacterial, anti-inflammatory, and pro-regenerative functions, offering a promising therapeutic strategy for MRSA-infected wound repair.<\/jats:p>","DOI":"10.1021\/acsami.6c08389","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:01:39Z","timestamp":1789156899000},"page":"50491-50510","source":"Crossref","is-referenced-by-count":0,"title":["Carrier-Free Glycyrrhizic Acid and Baicalin Co-Assembled Hydrogel for Methicillin-Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    Infected Wound Repair"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1212-6826","authenticated-orcid":true,"given":"Feng","family":"Ye","sequence":"first","affiliation":[{"name":"The Second Qilu Hospital of Shandong University , , , ,","place":["Jinan, Shandong, China, 250033"]},{"name":"Shandong University , , , ,","place":["Jinan, Shandong, China, 250033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Zhai","sequence":"additional","affiliation":[{"name":"The Second Qilu Hospital of Shandong University , , , ,","place":["Jinan, Shandong, China, 250033"]},{"name":"Shandong University , , , ,","place":["Jinan, Shandong, China, 250033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingze","family":"Xu","sequence":"additional","affiliation":[{"name":"The Second Qilu Hospital of Shandong University , , , ,","place":["Jinan, Shandong, China, 250033"]},{"name":"Shandong University , , , ,","place":["Jinan, Shandong, China, 250033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Qilu Hospital of Shandong University , , , ,","place":["Jinan, Shandong, China, 250033"]},{"name":"Shandong University , , , ,","place":["Jinan, Shandong, China, 250033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3302-912X","authenticated-orcid":true,"given":"Yanjiao","family":"Ding","sequence":"additional","affiliation":[{"name":"Shandong Second Provincial General Hospital , , , ,","place":["Jinan, Shandong, China, 250022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliang","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Qilu Hospital of Shandong University , , , ,","place":["Jinan, Shandong, China, 250033"]},{"name":"Shandong University , , , ,","place":["Jinan, Shandong, China, 250033"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"2026100820082753800_cit1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"key":"2026100820082753800_cit2","doi-asserted-by":"publisher","first-page":"e392","DOI":"10.1016\/S1473-3099(19)30276-2","article-title":"Improving the estimation of the global burden of antimicrobial resistant infections","volume":"19","author":"Limmathurotsakul","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"2026100820082753800_cit3","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1126\/science.8093647","article-title":"Evidence for a Clonal Origin of Methicillin Resistance in Staphylococcus aureus","volume":"259","author":"Kreiswirth","year":"1993","journal-title":"Science"},{"key":"2026100820082753800_cit4","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1073\/pnas.1715218115","article-title":"Phosphorylation-dependent activation of the cell wall synthase PBP2a in Streptococcus pneumoniae by MacP","volume":"115","author":"Fenton","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026100820082753800_cit5","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1146\/annurev-biochem-060614-034516","article-title":"Mechanisms of Methicillin Resistance in Staphylococcus aureus","volume":"84","author":"Peacock","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"2026100820082753800_cit6","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1111\/j.1469-0691.1998.tb00682.x","article-title":"Introduction: Evolving needs in respiratory tract infections","volume":"4","author":"Mandell","year":"1998","journal-title":"Clin. Microbiol. Infect."},{"key":"2026100820082753800_cit7","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/s41586-022-05583-3","article-title":"Structural basis of broad-spectrum \u03b2-lactam resistance in Staphylococcus aureus","volume":"613","author":"Alexander","year":"2023","journal-title":"Nature"},{"key":"2026100820082753800_cit8","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202503023","article-title":"Vm\u2013MSI: a Vancomycin\u2013Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum","volume":"13","author":"Li","year":"2026","journal-title":"Adv. Sci."},{"key":"2026100820082753800_cit9","doi-asserted-by":"publisher","first-page":"11251","DOI":"10.1038\/s41467-025-66118-8","article-title":"Vancomycin heteroresistance (hVISA) in MRSA links to treatment failure and supports a revised PAP-AUC threshold","volume":"16","author":"Fatsis-Kavalopoulos","year":"2025","journal-title":"Nat. Commun."},{"key":"2026100820082753800_cit10","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s13054-019-2523-5","article-title":"Comparative efficacy of linezolid and vancomycin for endotracheal tube MRSA biofilms from ICU patients","volume":"23","author":"Fern\u00e1ndez-Barat","year":"2019","journal-title":"Crit. Care"},{"key":"2026100820082753800_cit11","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1086\/648673","article-title":"Immunogenicity of Toxins during Staphylococcus aureus Infection","volume":"50","author":"Verkaik","year":"2010","journal-title":"Clin. Infec. Dis."},{"key":"2026100820082753800_cit12","doi-asserted-by":"publisher","first-page":"3582","DOI":"10.1128\/JCM.00657-10","article-title":"Virulence Genes and Genotypic Associations in Nasal Carriage, Community-Associated Methicillin-Susceptible and Methicillin-Resistant USA400 Staphylococcus aureus Isolates","volume":"48","author":"Shukla","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"2026100820082753800_cit13","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nrmicro.2017.27","article-title":"Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors","volume":"15","author":"Spaan","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"2026100820082753800_cit14","doi-asserted-by":"publisher","first-page":"7416","DOI":"10.1073\/pnas.1721949115","article-title":"Staphylococcus aureus biofilms release leukocidins to elicit extracellular trap formation and evade neutrophil-mediated killing","volume":"115","author":"Bhattacharya","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026100820082753800_cit15","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s12964-024-01511-2","article-title":"Deciphering the dynamics of methicillin-resistant Staphylococcus aureus biofilm formation: from molecular signaling to nanotherapeutic advances","volume":"22","author":"Aboelnaga","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"2026100820082753800_cit16","doi-asserted-by":"publisher","first-page":"15975","DOI":"10.1021\/acsami.7b03208","article-title":"Direct Synthesis of Dextran-Based Antibacterial Hydrogels for Extended Release of Biocides and Eradication of Topical Biofilms","volume":"9","author":"Hoque","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026100820082753800_cit17","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay9597","article-title":"A new coumarin compound DCH combats methicillin-resistant Staphylococcus aureus biofilm by targeting arginine repressor","volume":"6","author":"Qu","year":"2020","journal-title":"Sci. Adv."},{"key":"2026100820082753800_cit18","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301694","article-title":"A Photomodulable Bacteriophage-Spike Nanozyme Enables Dually Enhanced Biofilm Penetration and Bacterial Capture for Photothermal-Boosted Catalytic Therapy of MRSA Infections","volume":"10","author":"Wu","year":"2023","journal-title":"Adv. Sci."},{"key":"2026100820082753800_cit19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41586-024-07530-w","article-title":"Sophisticated natural products as antibiotics","volume":"632","author":"Lewis","year":"2024","journal-title":"Nature"},{"key":"2026100820082753800_cit20","doi-asserted-by":"publisher","first-page":"7164","DOI":"10.1038\/s41467-022-34883-5","article-title":"Biomimetic electrodynamic nanoparticles comprising ginger-derived extracellular vesicles for synergistic anti-infective therapy","volume":"13","author":"Qiao","year":"2022","journal-title":"Nat. Commun."},{"key":"2026100820082753800_cit21","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nrmicro2333","article-title":"How antibiotics kill bacteria: from targets to networks","volume":"8","author":"Kohanski","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"2026100820082753800_cit22","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/281689a0","article-title":"Glycyrrhizic acid inhibits virus growth and inactivates virus particles","volume":"281","author":"Pompei","year":"1979","journal-title":"Nature"},{"key":"2026100820082753800_cit23","doi-asserted-by":"publisher","first-page":"6219","DOI":"10.2174\/0929867325666191011115407","article-title":"Advances in Pharmacological Activities and Mechanisms of Glycyrrhizic Acid","volume":"27","author":"Chen","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"2026100820082753800_cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101347","article-title":"Difluoroboron curcumin\/glycyrrhizic acid liposome-incorporated Mg2+-chelated microgel for MRSA-infected wound photothermal therapy","volume":"85","author":"Zhu","year":"2026","journal-title":"Drug Resist. Updates"},{"key":"2026100820082753800_cit25","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202412581","article-title":"Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"2026100820082753800_cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112977","article-title":"Ferrous iron-induced formation of glycyrrhizic acid hydrogels for Staphylococcus aureus-infected wound healing","volume":"221","author":"Xu","year":"2023","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"2026100820082753800_cit27","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.bioactmat.2025.07.002","article-title":"Multifunctional hydrogel encapsulated with baicalin for full-layer regeneration of drug-resistant bacteria-infected wounds after radiotherapy","volume":"53","author":"Yuan","year":"2025","journal-title":"Bioac. Mater."},{"key":"2026100820082753800_cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.165054","article-title":"Synergistic treatment of respiratory syncytial virus induced pneumonia by multifunctional Baicalin-Resveratrol self-assembled nanomedicine","volume":"519","author":"Chang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"2026100820082753800_cit29","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.bioorg.2016.10.004","article-title":"Baicalin, a natural LSD1 inhibitor","volume":"69","author":"Zheng","year":"2016","journal-title":"Bioorg. Chem."},{"key":"2026100820082753800_cit30","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1039\/d4mh01213e","article-title":"Chiral helix amplification and enhanced bioadhesion of two-component low molecular weight hydrogels regulated by OH to eradicate MRSA biofilms","volume":"12","author":"Wang","year":"2025","journal-title":"Mater. Horiz."},{"key":"2026100820082753800_cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123298","article-title":"A remotely controlled nanotherapeutic with immunomodulatory property for MRSA-induced bone infection","volume":"321","author":"Zhao","year":"2025","journal-title":"Biomaterials"},{"key":"2026100820082753800_cit32","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202205528","article-title":"Natural Carrier-Free Binary Small Molecule Self-Assembled Hydrogel Synergize Antibacterial Effects and Promote Wound Healing by Inhibiting Virulence Factors and Alleviating the Inflammatory Response","volume":"19","author":"Wang","year":"2022","journal-title":"Small"},{"key":"2026100820082753800_cit33","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1080\/17460441.2020.1750591","article-title":"Nanonization techniques to overcome poor water-solubility with drugs","volume":"15","author":"Da Silva","year":"2020","journal-title":"Expert Opin. Drug Dis."},{"key":"2026100820082753800_cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120546","article-title":"Preparation, optimization, characterization and in vitro release of baicalein-solubilizing glycyrrhizic acid nano-micelles","volume":"601","author":"You","year":"2021","journal-title":"Int. J. Pharm."},{"key":"2026100820082753800_cit35","doi-asserted-by":"publisher","first-page":"4660","DOI":"10.1002\/ptr.7099","article-title":"Natural products: A lead for drug discovery and development","volume":"35","author":"Chopra","year":"2021","journal-title":"Phytother. Res."},{"key":"2026100820082753800_cit36","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.2147\/IJN.S132780","article-title":"High drug-loading nanomedicines: progress, current status, and prospects","volume":"12","author":"Shen","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"2026100820082753800_cit37","doi-asserted-by":"publisher","first-page":"22355","DOI":"10.1021\/acsnano.3c04556","article-title":"Exudate Absorbing and Antimicrobial Hydrogel Integrated with Multifunctional Curcumin-Loaded Magnesium Polyphenol Network for Facilitating Burn Wound Healing","volume":"17","author":"Gong","year":"2023","journal-title":"ACS Nano"},{"key":"2026100820082753800_cit38","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.ijpharm.2019.01.056","article-title":"Advances in nanocarriers enabled brain targeted drug delivery across blood brain barrier","volume":"559","author":"Sharma","year":"2019","journal-title":"Int. J. Pharm."},{"key":"2026100820082753800_cit39","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202314095","article-title":"Emerging Co-Assembled and Sustained Released Natural Medicinal Nanoparticles for Multitarget Therapy of Choroidal Neovascularization","volume":"36","author":"Shen","year":"2024","journal-title":"Adv. Mater."},{"key":"2026100820082753800_cit40","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.bioactmat.2023.06.018","article-title":"A metal ions-mediated natural small molecules carrier-free injectable hydrogel achieving laser-mediated photo-Fenton-like anticancer therapy by synergy apoptosis\/cuproptosis\/anti-inflammation","volume":"29","author":"Pi","year":"2023","journal-title":"Bioact. Mater."},{"key":"2026100820082753800_cit41","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403388","article-title":"Natural Products from Herbal Medicine Self-Assemble into Advanced Bioactive Materials","volume":"11","author":"Guo","year":"2024","journal-title":"Adv. Sci."},{"key":"2026100820082753800_cit42","doi-asserted-by":"publisher","first-page":"6770","DOI":"10.1021\/acsnano.9b01346","article-title":"Natural Berberine-Based Chinese Herb Medicine Assembled Nanostructures with Modified Antibacterial Application","volume":"13","author":"Li","year":"2019","journal-title":"ACS Nano"},{"key":"2026100820082753800_cit43","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202503283","article-title":"Atomic Insights Into Self-Assembly of Zingibroside R1 and its Therapeutic Action Against Fungal Diseases","volume":"37","author":"Peng","year":"2025","journal-title":"Adv. Mater."},{"key":"2026100820082753800_cit44","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1186\/s12951-022-01734-w","article-title":"Thermodynamics driving phytochemical self-assembly morphological change and efficacy enhancement originated from single and co-decoction of traditional chinese medicine","volume":"20","author":"Huang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"2026100820082753800_cit45","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.bioactmat.2025.06.027","article-title":"Skin's 'nano-shield' hydrogel: Co-delivery of myricetin-laurate nanoagents eliminates fungus and promotes skin regeneration","volume":"52","author":"Zhang","year":"2025","journal-title":"Bioact. Mater."},{"key":"2026100820082753800_cit46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2400812121","article-title":"The evolution of Traditional Chinese Medicine as recombinant inventions","volume":"121","author":"Wu","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026100820082753800_cit47","first-page":"3458","article-title":"Antibiotic sensitivity testing. Report of an international collaborative study","volume":"217","author":"Ericsson","year":"1971","journal-title":"Acta. Pathol. Microbiol. Scand. B"},{"key":"2026100820082753800_cit48","doi-asserted-by":"publisher","first-page":"648","DOI":"10.2144\/97234bm22","article-title":"Simplified agar plate method for quantifying viable bacteria","volume":"23","author":"Jett","year":"1997","journal-title":"BioTechniques"},{"key":"2026100820082753800_cit49","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.1128\/aem.02750-06","article-title":"Assessment and interpretation of bacterial viability by using the LIVE\/DEAD BacLight Kit in combination with flow cytometry","volume":"73","author":"Berney","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"2026100820082753800_cit50","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1017\/S1431927607070651","article-title":"High Resolution FESEM and TEM Reveal Bacterial Spore Attachment","volume":"13","author":"Panessa-Warren","year":"2007","journal-title":"Microsc. Microanal."},{"key":"2026100820082753800_cit51","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/s0076-6879(84)05047-3","article-title":"Detection of picomole levels of lipid hydroperoxides using a dichlorofluorescein fluorescent assay","volume":"105","author":"Cathcart","year":"1984","journal-title":"Methods Enzymol."}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c08389","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/37\/50491\/68488962\/am-2026-08389e.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/37\/50491\/68488962\/am-2026-08389e.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:10:09Z","timestamp":1791533409000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/18\/37\/50491\/5428715\/Carrier-Free-Glycyrrhizic-Acid-and-Baicalin-Co"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":51,"journal-issue":{"issue":"37","published-online":{"date-parts":[[2026,9,11]]},"published-print":{"date-parts":[[2026,9,23]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.6c08389","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]}}}