{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:42:46Z","timestamp":1791920566033,"version":"4.3.4"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100005767","name":"Anna University","doi-asserted-by":"publisher","award":["ACRF Fellowship"],"award-info":[{"award-number":["ACRF Fellowship"]}],"id":[{"id":"10.13039\/501100005767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Implant-associated infections (IAIs) driven by multidrug-resistant pathogens, such as Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (S. epidermidis), are two of the most challenging organisms responsible for recurrent implant failures. To mitigate this problem, we have developed broad-spectrum, efficient antibiofilm coatings for the titanium implant surface, which is modified with titania nanotube arrays (TNTA) via electrochemical methods. The resulting TNTA loaded with vancomycin (V-TNTA) and coated with polycaprolactone (PCL) fibers incorporating functionalized graphene oxide (GO) and l-arginine (VPGOA-TNTA) to restrict biofilm formation during the early four-week post-implantation. Spectroscopic and microscopic characterization techniques were performed to confirm the loading of vancomycin and successful coating of GO and l-arginine, including high-resolution scanning electron microscopy (HR-SEM) with energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM), X-ray diffraction (XRD), attenuated total reflectance and Fourier transform infrared (ATR-FTIR) spectroscopy, and wettability analyses. Next, in vitro antibacterial investigations revealed significant antibacterial and antibiofilm efficacy of VPGOA-TNTA-modified surfaces against MRSA and S. epidermidis, as evidenced by growth curves, CFU\/mL, and relative biofilm reduction on the implant surface. Reactive oxygen species (ROS) analysis confirmed the enhanced antibacterial activity of VPGOA-TNTA. Further, the VPGOA-TNTA demonstrated significant cell viability with MG63 cells. Notably, VPGOA-TNTA-modified surfaces also exhibited excellent hemocompatibility. Furthermore, a scratch assay with 3T3 fibroblasts demonstrated remarkable wound-healing activity. In addition, the Alzarin Red S (ARS) staining assay confirmed osteoblastic mineralization on VPGOA-TNTA, showing substantial calcium deposition in MG63 cells. Overall, our findings indicate that VPGOA-TNTA is a promising orthopedic implant material for eradicating the MRSA and S. epidermidis infections while promoting osseointegration.<\/jats:p>","DOI":"10.1021\/acsami.6c08409","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T04:01:46Z","timestamp":1785988906000},"page":"43724-43746","source":"Crossref","is-referenced-by-count":1,"title":["Hierarchical Titania Nanotube-Graphene Oxide-Arginine Interfaces for Tunable Drug Release and Enhanced Antibiofilm Performance"],"prefix":"10.1021","volume":"18","author":[{"given":"Swathi","family":"Puli","sequence":"first","affiliation":[{"name":"Anna University , , CEG campus , , ,","place":["Chennai, Tamil Nadu, India, 600025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh M.","family":"Lalitha","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research Thiruvananthapuram , , Maruthamala P.O., Vithura , , ,","place":["Thiruvananthapuram, Kerala, India, 695551"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1811-2428","authenticated-orcid":true,"given":"Rajendra","family":"Kurapati","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research Thiruvananthapuram , , Maruthamala P.O., Vithura , , ,","place":["Thiruvananthapuram, Kerala, India, 695551"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6394-1260","authenticated-orcid":true,"given":"Rajendran","family":"Nallaiyan","sequence":"additional","affiliation":[{"name":"Anna University , , CEG campus , , ,","place":["Chennai, Tamil Nadu, India, 600025"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"2026090317191145700_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfcoat.2020.126117","article-title":"A functionalized duplex coating on CP-titanium for biomedical applications","volume":"399","author":"Cheraghali","year":"2020","journal-title":"Surf. 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