{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:08:12Z","timestamp":1789758492738,"version":"4.0.1"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Lvliang City","award":["2024SHFZ27"],"award-info":[{"award-number":["2024SHFZ27"]}]},{"name":"Yichang municipal health commission"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic nonhealing wounds remain a critical clinical challenge due to persistent bacterial infection, tissue hypoxia, and impaired cellular regeneration. Herein, inspired by the \u201cpopping\u201d mechanism of Pop Rocks candy, we developed a multifunctional microneedle (MN) patch (Exo\/ONB-MN) that integrates antibacterial hyperbranched polymer (HBPLT), mesenchymal stem cell-derived exosomes (MSC-Exos), and oxygen nanobubbles (ONBs) into a single dissolvable platform. The HBPLT component provides potent broad-spectrum antibacterial activity through physical membrane disruption. Upon application, ONBs embedded in the needle bases explosively release oxygen, generating a directional pressure wave that actively propels exosomes from the needle tips deep into the wound bed\u2014a mechanism termed bubble-driven exosome propulsion. Concurrently, oxygen release alleviates local hypoxia, enhancing exosome uptake and amplifying their proregenerative effects. In vitro studies demonstrated that the Exo\/ONB-MN patch significantly promoted fibroblast proliferation and migration while achieving near-complete eradication of Staphylococcus aureus and Escherichia coli. In an S. aureus-infected full-thickness wound mouse model, the patch accelerated wound closure to nearly 100% within 14 days, promoted organized collagen deposition, reduced pro-inflammatory cytokine expression, and induced a phenotypic switch from M1 to M2 macrophages. This Pop Rocks-inspired platform addresses the key pathological barriers of chronic wounds\u2014infection, hypoxia, and impaired healing\u2014through a synergistic, all-in-one strategy, offering a promising and translatable approach for advanced wound management.<\/jats:p>","DOI":"10.1021\/acsami.6c08673","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:02:02Z","timestamp":1786665722000},"page":"44938-44950","source":"Crossref","is-referenced-by-count":0,"title":["Pop Rocks-Inspired Bubble Driven Exosome Propulsion\n                    <i>via<\/i>\n                    Microneedles for Synergistic Wound Healing"],"prefix":"10.1021","volume":"18","author":[{"given":"Lei","family":"Wu","sequence":"first","affiliation":[{"name":"Yichang Central People's Hospital , , , ,","place":["Yichang, Hubei, China, 443000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5161-3945","authenticated-orcid":true,"given":"Weigang","family":"Hu","sequence":"additional","affiliation":[{"name":"Yichang Central People\u2019s Hospital , , , ,","place":["Yichang, Hubei, China, 443000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yichang Central People\u2019s Hospital , , , ,","place":["Yichang, Hubei, China, 443000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Yichang Central People\u2019s Hospital , , , ,","place":["Yichang, Hubei, China, 443000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"He","sequence":"additional","affiliation":[{"name":"Yichang Central People's Hospital , , , ,","place":["Yichang, Hubei, China, 443000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Ye","sequence":"additional","affiliation":[{"name":"Nanchang University , , , ,","place":["Nanchang, Jiangxi, China, 330031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenke","family":"Guo","sequence":"additional","affiliation":[{"name":"Fenyang Hospital of Shanxi Province , , , ,","place":["Lvliang, Shanxi, China, 032200"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"8058","key":"2026091814061886900_cit1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/d41586-025-00906-6","article-title":"Skin wound healing measured remotely through molecular flux","volume":"640","author":"Chen","year":"2025","journal-title":"Nature"},{"issue":"17","key":"2026091814061886900_cit2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300816","article-title":"3D-printed functional hydrogel by dna-induced biomineralization for accelerated diabetic wound healing","volume":"10","author":"Kim","year":"2023","journal-title":"Adv. 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