{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:46:29Z","timestamp":1792784789193,"version":"4.5.0"},"reference-count":33,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52306100"],"award-info":[{"award-number":["52306100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Key Laboratory of Cryogenic Science and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences","award":["T-2025cryo-14"],"award-info":[{"award-number":["T-2025cryo-14"]}],"id":[{"id":"https:\/\/ror.org\/04akaak77","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Shandong Provincial Natural Science Foundation","award":["ZR2023QE305"],"award-info":[{"award-number":["ZR2023QE305"]}]},{"name":"Shandong Provincial Natural Science Foundation","award":["ZR2024ME103"],"award-info":[{"award-number":["ZR2024ME103"]}]},{"name":"Shandong Provincial Natural Science Foundation","award":["ZR2026LJS015"],"award-info":[{"award-number":["ZR2026LJS015"]}]},{"name":"Science and Technology Program of Guangdong Province","award":["2025A0505020025"],"award-info":[{"award-number":["2025A0505020025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Photothermal-responsive microneedles (PRMNs) are promising tools for controlled, on-demand transdermal delivery of low-permeability drugs like Methotrexate. While effective, their underlying heat and drug transfer mechanisms, particularly the role of Soret effect-induced thermodiffusion, remain unclear. This study develops a theoretical framework that integrates heat transfer induced by light irradiation with molecular transport governed by both Fick\u2019s diffusion and the Soret effect while accounting for skin heterogeneity and temperature-dependent diffusion. Using a geometric PRMN-skin model, we numerically investigated the temperature distribution, temporal drug concentration, and cumulative drug amount under various irradiation conditions. Fluorescence experiments with polyvinyl alcohol PRMNs in porcine skin were performed, and the temperature evolution and temporal drug release were analyzed. The Soret effect was found to act as an active thermodiffusion mechanism augmenting the intrinsically concentration-gradient-driven transport. The current framework lays a foundation for instrumentation of PRMNs and optical components as a whole and their implementation as wearable devices thereafter.<\/jats:p>","DOI":"10.1021\/acsami.6c08720","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:01:57Z","timestamp":1789574517000},"page":"51992-52005","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive Modeling of Heat and Diffusional Drug Transfer in Photothermal-Responsive Microneedles Applied to Skin"],"prefix":"10.1021","volume":"18","author":[{"given":"Wenduo","family":"Wu","sequence":"first","affiliation":[{"name":"Shandong University , , , ,","place":["Jinan, Shandong, China, 250061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Shandong University , , , ,","place":["Jinan, Shandong, China, 250061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong University , , , ,","place":["Jinan, Shandong, China, 250061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chonghui","family":"Yang","sequence":"additional","affiliation":[{"name":"Shandong University , , , ,","place":["Jinan, Shandong, China, 250061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Qin","sequence":"additional","affiliation":[{"name":"The Second Qilu Hospital, Cheeloo College of Medicine, Shandong University , , , ,","place":["Jinan, Shandong, China, 250033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Quan","sequence":"additional","affiliation":[{"name":"Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100190"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegah","family":"Pezeshkpour","sequence":"additional","affiliation":[{"name":"University of Alberta , , , ,","place":["Edmonton, Alberta, Canada, T6G 2H5"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7158-3894","authenticated-orcid":true,"given":"Ning","family":"Qin","sequence":"additional","affiliation":[{"name":"Shandong University , , , ,","place":["Jinan, Shandong, China, 250061"]},{"name":"Shenzhen Research Institute of Shandong University , , ,","place":["Shenzhen, Guangdong, China, 518000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shandong University , , , ,","place":["Jinan, Shandong, China, 250061"]},{"name":"Shenzhen Research Institute of Shandong University , , ,","place":["Shenzhen, Guangdong, China, 518000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"2026093001072344100_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.115109","article-title":"Strategies to Develop Polymeric Microneedles for Controlled Drug Release","volume":"203","author":"Chen","year":"2023","journal-title":"Adv. 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