{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:01:06Z","timestamp":1786114866667,"version":"build-2736575974"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100018617","name":"Liaoning Revitalization Talents Program","doi-asserted-by":"publisher","award":["XLYC2503083"],"award-info":[{"award-number":["XLYC2503083"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2025-MS-246"],"award-info":[{"award-number":["2025-MS-246"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900869"],"award-info":[{"award-number":["81900869"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY24H160019"],"award-info":[{"award-number":["LY24H160019"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ25H300003"],"award-info":[{"award-number":["LZ25H300003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Liaoning Province Science and Technology Plan Joint Program","award":["2024JH2\/102600182"],"award-info":[{"award-number":["2024JH2\/102600182"]}]},{"name":"Liaoning Province Science and Technology Plan Joint Program","award":["2024JH2\/102600184"],"award-info":[{"award-number":["2024JH2\/102600184"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Protein therapeutics have garnered significant enthusiasm for oncological applications, owing to their exquisite specificity and intrinsic bioactivity. Yet, proteins remain constrained by limited transcellular permeability and proteolytic susceptibility during delivery. To circumvent these impediments, we engineered a redox-responsive protein prodrug, RP-ss-PK, via covalent conjugation of cytotoxic proteinase K (PK) to a multifunctional polymer, RGD-PEG-ss-NPC. This linear hetero-difunctional PEG scaffold contains a cyclic RGD peptide at the \u03b1-terminus for integrin-mediated tumor targeting and a 4-nitrophenyl ethyl carbonate (NPC) group at the \u03c9-terminus for site-specific conjugation to amine-rich lysine residues on PK. An internal disulfide linker (\u2013ss\u2013) renders the prodrug cleavable in the presence of intracellular glutathione (GSH). Upon systemic administration, RP-ss-PK selectively accumulates within neoplastic lesions via RGD\u2212integrin (\u03b1v\u03b23\/\u03b1v\u03b25) recognition. Endocytosis exposes the disulfide tether to the cytosolic glutathione milieu, triggering reductive cleavage and subsequent liberation of native, fully active PK. The unleashed protease initiates indiscriminate proteolysis that precipitates rapid tumor cell death, accompanied by plasma-membrane permeabilization. This membrane disruption facilitates the extracellular release of damage-associated molecular patterns (DAMPs), thereby igniting anti-tumor immunity and remodeling the tumor microenvironment. Collectively, this prodrug paradigm not only amplifies the tumor-selective delivery of protein therapeutics but also exemplifies a facile, broadly applicable strategy for intracellular activation and functional restoration of protein cargos. Our findings establish RP-ss-PK as a versatile platform poised for the targeted protein treatment of diverse pathologies.<\/jats:p>","DOI":"10.1021\/acsami.6c08784","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:34:27Z","timestamp":1783712067000},"page":"41690-41707","source":"Crossref","is-referenced-by-count":0,"title":["Glutathione-Triggered Unleashing of Protease K Prodrug Suppressed Primary Tumors and Its Metastasis with Stimulated Anti-tumor Immunity"],"prefix":"10.1021","volume":"18","author":[{"given":"Xiaolan","family":"Yin","sequence":"first","affiliation":[{"name":"Cancer Hospital of Dalian University of Technology , , No. 44 Xiaoheyan Road , Dadong District, ,","place":["Shenyang, China, 110042"]},{"name":"Dalian University of Technology , , 2 Linggong Road , ,","place":["Dalian, China, 116024"]},{"name":"Zhejiang University , , ,","place":["Jiaxing, China, 314100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dalian University of Technology , , 2 Linggong Road , ,","place":["Dalian, China, 116024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junshuai","family":"Cui","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of Dalian Medical University , , ,","place":["Dalian, China, 116023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Chen","sequence":"additional","affiliation":[{"name":"Dalian Medical University , , ,","place":["Dalian, China, 116044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Cui","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Jiaxing, China, 314100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-5017","authenticated-orcid":true,"given":"Liuwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Jiaxing, China, 314100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 200433"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Cancer Hospital of Dalian University of Technology , , No. 44 Xiaoheyan Road , Dadong District, ,","place":["Shenyang, China, 110042"]},{"name":"Cancer Hospital of Dalian University of Technology , , No. 44 Xiaoheyan Road , Dadong District, ,","place":["Shenyang, China, 110042"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Hospital of Dalian University of Technology , , No. 44 Xiaoheyan Road , Dadong District, ,","place":["Shenyang, China, 110042"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2721-0337","authenticated-orcid":true,"given":"Haidong","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Hospital of Dalian University of Technology , , No. 44 Xiaoheyan Road , Dadong District, ,","place":["Shenyang, China, 110042"]},{"name":"Dalian University of Technology , , 2 Linggong Road , ,","place":["Dalian, China, 116024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3248-9747","authenticated-orcid":true,"given":"Jingyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Dalian University of Technology , , 2 Linggong Road , ,","place":["Dalian, China, 116024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3091-671X","authenticated-orcid":true,"given":"Qixian","family":"Chen","sequence":"additional","affiliation":[{"name":"Cancer Hospital of Dalian University of Technology , , No. 44 Xiaoheyan Road , Dadong District, ,","place":["Shenyang, China, 110042"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"2026080518082854000_cit1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.addr.2015.10.021","article-title":"Co-Delivery of Chemotherapeutics and Proteins for Synergistic Therapy","volume":"98","author":"He","year":"2016","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026080518082854000_cit2","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1021\/acsnano.8b07746","article-title":"Rational Design of Cancer Nanomedicine for Simultaneous Stealth Surface and Enhanced Cellular Uptake","volume":"13","author":"Jin","year":"2019","journal-title":"ACS Nano"},{"key":"2026080518082854000_cit3","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202102600","article-title":"Harnessing the Therapeutic Potential of Biomacromolecules through Intracellular Delivery of Nucleic Acids, Peptides, and Proteins","volume":"11","author":"Tian","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"2026080518082854000_cit4","doi-asserted-by":"publisher","first-page":"12888","DOI":"10.1021\/acsami.0c23124","article-title":"Entropy-Driven Quick Loading of Functional Proteins in Nanohydrogels for Highly Efficient Tumor Targeting Therapy","volume":"13","author":"Sun","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026080518082854000_cit5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.actbio.2023.09.018","article-title":"Engineered Therapeutic Proteins for Sustained-Release Drug Delivery Systems","volume":"171","author":"Nguyen","year":"2023","journal-title":"Acta Biomater."},{"key":"2026080518082854000_cit6","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ymthe.2023.11.012","article-title":"GalNAc-Conjugated siRNA Targeting the DNAJB1-PRKACA Fusion Junction in Fibrolamellar Hepatocellular Carcinoma","volume":"32","author":"Neumayer","year":"2023","journal-title":"Mol. Ther."},{"key":"2026080518082854000_cit7","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1158\/0008-5472.CAN-12-0320","article-title":"Inhibiting Systemic Autophagy during Interleukin 2 Immunotherapy Promotes Long-Term Tumor Regression","volume":"72","author":"Liang","year":"2012","journal-title":"Cancer Res."},{"key":"2026080518082854000_cit8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.12688\/f1000research.9970.1","article-title":"Recent Advances in (Therapeutic Protein) Drug Development","volume":"6","author":"Lagass\u00e9","year":"2017","journal-title":"F1000Res."},{"key":"2026080518082854000_cit9","doi-asserted-by":"publisher","first-page":"30493","DOI":"10.1021\/acsami.2c03763","article-title":"Charge-Reversible Pro-Ribonuclease Enveloped in Virus-Like Synthetic Nanocapsules for Systemic Treatment of Intractable Glioma","volume":"14","author":"Cui","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026080518082854000_cit10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nrd2399","article-title":"Protein Therapeutics: A Summary and Pharmacological Classification","volume":"7","author":"Leader","year":"2007","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"1","key":"2026080518082854000_cit11","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/s41392-022-00904-4","article-title":"Therapeutic Peptides: Current Applications and Future Directions","volume":"7","author":"Wang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"2026080518082854000_cit12","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1038\/s41467-023-38039-x","article-title":"Engineering Protein-Based Therapeutics through Structural and Chemical Design","volume":"14","author":"Ebrahimi","year":"2023","journal-title":"Nat. Commun."},{"key":"2026080518082854000_cit13","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1002\/cjoc.202000655","article-title":"Design of Polymers for Intracellular Protein and Peptide Delivery","volume":"39","author":"Cheng","year":"2021","journal-title":"Chin. J. Chem."},{"key":"2026080518082854000_cit14","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201902791","article-title":"Rational Design of Nanocarriers for Intracellular Protein Delivery","volume":"31","author":"Qin","year":"2019","journal-title":"Adv. Mater."},{"key":"2026080518082854000_cit15","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/jbm.a.34859","article-title":"Cell-Penetrating Peptides: Achievements and Challenges in Application for Cancer Treatment","volume":"102","author":"Shin","year":"2013","journal-title":"J. Biomed. Mater. Res. A"},{"key":"2026080518082854000_cit16","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jconrel.2015.04.038","article-title":"PEG Shielded MMP Sensitive CPPs for Efficient and Tumor Specific Gene Delivery In Vivo","volume":"209","author":"Veiman","year":"2015","journal-title":"J. Control. Release"},{"key":"2026080518082854000_cit17","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800685","article-title":"Protein Nanotherapeutics as an Emerging Modality for Cancer Therapy","volume":"7","author":"Cheng","year":"2018","journal-title":"Adv. Healthcare Mater."},{"key":"2026080518082854000_cit18","doi-asserted-by":"publisher","first-page":"2868","DOI":"10.1073\/pnas.1520244113","article-title":"Efficient Delivery of Genome-Editing Proteins Using Bioreducible Lipid Nanoparticles","volume":"113","author":"Wang","year":"2016","journal-title":".Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026080518082854000_cit19","doi-asserted-by":"publisher","first-page":"18214","DOI":"10.1021\/acsnano.1c07166","article-title":"Redox-Responsive Molecularly Imprinted Nanoparticles for Targeted Intracellular Delivery of Protein toward Cancer Therapy","volume":"15","author":"Lu","year":"2021","journal-title":"ACS Nano"},{"key":"2026080518082854000_cit20","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1073\/pnas.0914140107","article-title":"Mechanism of Active Targeting in Solid Tumors with Transferrin-Containing Gold Nanoparticles","volume":"107","author":"Choi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026080518082854000_cit21","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302656","article-title":"A pH-Responsive Virus-Like Particle as a Protein Cage for Targeted Delivery","volume":"13","author":"Kim","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"2026080518082854000_cit22","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.jcis.2022.12.018","article-title":"pH-Responsive Organic\/Inorganic Hybrid Nanocolloids for Transcellular Delivery of Ribonucleolytic Payloads toward Targeted Anti-Glioma Therapy","volume":"634","author":"Cui","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"2026080518082854000_cit23","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.jconrel.2022.09.033","article-title":"Multifunctional Stimuli-Responsive Hybrid Nanogels for Cancer Therapy: Current Status and Challenges","volume":"351","author":"Ali","year":"2022","journal-title":"J. Control. Release"},{"key":"2026080518082854000_cit24","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12951-018-0398-2","article-title":"Advances in Redox-Responsive Drug Delivery Systems of Tumor Microenvironment","volume":"16","author":"Guo","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"2026080518082854000_cit25","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1021\/accountsmr.4c00149","article-title":"Rational Engineering of Cytosolic Delivery Systems for Protein Therapeutics","volume":"5","author":"Lv","year":"2024","journal-title":"Acc. Mater. Res."},{"key":"2026080518082854000_cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.157232","article-title":"MnO2 and Sonosensitizer-Based Nano-Platforms for Cancer Sonodynamic Therapy","volume":"500","author":"Yang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"2026080518082854000_cit27","doi-asserted-by":"publisher","first-page":"3881","DOI":"10.1021\/acsnano.1c09048","article-title":"Nitric Oxide Induces Immunogenic Cell Death and Potentiates Cancer Immunotherapy","volume":"16","author":"Jiang","year":"2022","journal-title":"ACS Nano"},{"key":"2026080518082854000_cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.151437","article-title":"Nano-Assemblies Overcome Cancer Multidrug Resistance for Effectively Synergistic Chemo-Immuno-Oncotherapy","volume":"490","author":"Liu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"2026080518082854000_cit29","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.70001","article-title":"Integrin-Targeted, Activatable Nanophototherapeutics for Immune Modulation: Enhancing Photoimmunotherapy Efficacy in Prostate Cancer through Macrophage Reprogramming","volume":"6","author":"Zhang","year":"2025","journal-title":"Aggregate"},{"key":"2026080518082854000_cit30","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1038\/s41551-021-00803-z","article-title":"Conjugation of Glucosylated Polymer Chains to Checkpoint Blockade Antibodies Augments Their Efficacy and Specificity for Glioblastoma","volume":"5","author":"Yang","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"2026080518082854000_cit31","doi-asserted-by":"publisher","DOI":"10.1002\/smo2.70055","article-title":"Redox-responsive dual-drug nanomedicine integrating cisplatin and trypsin for synergistic reversal of tumor chemoresistance","author":"Yin","year":"2026","journal-title":"Smart Mol."},{"key":"2026080518082854000_cit32","doi-asserted-by":"publisher","first-page":"4078","DOI":"10.1021\/acs.nanolett.5c00341","article-title":"Multivalent RGD Peptide-Mediated Nanochimera for Lysosomal Degradation of PDL1 Protein","volume":"25","author":"Song","year":"2025","journal-title":"Nano Lett."},{"key":"2026080518082854000_cit33","doi-asserted-by":"publisher","first-page":"14859","DOI":"10.1021\/acsami.4c18502","article-title":"Tumor Microenvironment-Responsive Nanodrug for Embolotherapy and Enhanced Chemotherapy","volume":"17","author":"Zheng","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026080518082854000_cit34","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1021\/acs.biomac.2c00152","article-title":"Reversible Chemical Protein Modification to Endogenous Glutathione and Its Utilities in the Manufacture of Transcellular Pro-Enzymes","volume":"23","author":"Wang","year":"2022","journal-title":"Biomacromolecules"},{"key":"2026080518082854000_cit35","doi-asserted-by":"publisher","DOI":"10.1088\/1468-6996\/16\/3\/035004","article-title":"Density-Tunable Conjugation of Cyclic RGD Ligands with Polyion Complex Vesicles for the Neovascular Imaging of Orthotopic Glioblastomas","volume":"16","author":"Kawamura","year":"2015","journal-title":"Sci. Technol. Adv. Mater."},{"key":"2026080518082854000_cit36","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1021\/bc050263o","article-title":"DNA Transfer into Human Lung Cells Is Improved with Tat\u2212RGD Peptide by Caveoli-Mediated Endocytosis","volume":"17","author":"Renigunta","year":"2006","journal-title":"Bioconjugate Chem."},{"issue":"6","key":"2026080518082854000_cit37","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1021\/mp800070s","article-title":"Polyplex Micelles with Cyclic RGD Peptide Ligands and Disulfide Cross-Links Directing to the Enhanced Transfection via Controlled Intracellular Trafficking","volume":"5","author":"Oba","year":"2008","journal-title":"Mol. Pharm."},{"key":"2026080518082854000_cit38","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1038\/s41467-021-22126-y","article-title":"Quantitative Characterization of Extracellular Vesicle Uptake and Content Delivery within Mammalian Cells","volume":"12","author":"Bonsergent","year":"2021","journal-title":"Nat. Commun."},{"key":"2026080518082854000_cit39","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13030256","article-title":"Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses","volume":"13","author":"Duan","year":"2024","journal-title":"Antioxidants"},{"key":"2026080518082854000_cit40","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202400196","article-title":"Activating Iterative Revolutions of the Cancer-Immunity Cycle in Hypoxic Tumors with a Smart Nano-Regulator","volume":"36","author":"Ding","year":"2024","journal-title":"Adv. Mater."},{"key":"2026080518082854000_cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122089","article-title":"Photothermal \u201cNano-Dot\u201d Reactivate \u201cImmune-Hot\u201d for Tumor Treatment via Reprogramming Cancer Cells Metabolism","volume":"296","author":"Lu","year":"2023","journal-title":"Biomaterials"},{"key":"2026080518082854000_cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.137652","article-title":"A Cancer Theranostic Nanoplatform for Second Near-Infrared Fluorescence Imaging-Guided Carbon Monoxide-Sensitized Mild Photothermal Therapy with ICD Induction","volume":"693","author":"Gan","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"2026080518082854000_cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.154566","article-title":"NaCe0.7Fx:Gd0.1,Tb02 Nanoscintillator as a New Sonosensitizer for Potentiating Cancer Sonodynamic-Immune Therapy","volume":"497","author":"Liu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"2026080518082854000_cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.138158","article-title":"Sustained-Release Hydrogel System for Preventing Postoperative Tumor Recurrence through Synergistic Immune Signal Enhancement for T Cell Activation","volume":"699","author":"Hu","year":"2025","journal-title":"J. Colloid Interface Sci."}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c08784","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/30\/41690\/65854420\/am-2026-08784q.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/30\/41690\/65854420\/am-2026-08784q.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T22:23:42Z","timestamp":1785968622000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/18\/30\/41690\/5205359\/Glutathione-Triggered-Unleashing-of-Protease-K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":44,"journal-issue":{"issue":"30","published-online":{"date-parts":[[2026,7,10]]},"published-print":{"date-parts":[[2026,8,5]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.6c08784","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]}}}