{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:45:44Z","timestamp":1792784744904,"version":"4.5.0"},"reference-count":68,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M720602"],"award-info":[{"award-number":["2022M720602"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Postdoctoral Science Foundation of The First Affiliated Hospital of Chongqing Medical University","award":["CYYY-BSHPYXM- 202302"],"award-info":[{"award-number":["CYYY-BSHPYXM- 202302"]}],"id":[{"id":"https:\/\/ror.org\/033vnzz93","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Chongqing Special Postdoctoral Science Foundation","award":["XmT2022072"],"award-info":[{"award-number":["XmT2022072"]}]},{"name":"Natural Science Foundation of Chongqing","award":["CSTB2023NSCQ-MSX0269"],"award-info":[{"award-number":["CSTB2023NSCQ-MSX0269"]}]},{"name":"Natural Science Foundation of Chongqing","award":["CSTB2024NSCQ-MSX0034"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0034"]}]},{"name":"Qian De Qingmiao Talent Enhancement Project","award":["2025QDTS-14"],"award-info":[{"award-number":["2025QDTS-14"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["82202772"],"award-info":[{"award-number":["82202772"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["82203017"],"award-info":[{"award-number":["82203017"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pathological skin scarring is still a major obstacle due to functional impairment and psychological diseases. Excessive reactive oxygen species (ROS) can hinder the healing of skin wound and increase the formation of scar tissues. To address this dilemma here, manganese dioxide (MnO2) nanozyme-constituted GelMA hydrogel was designed to eliminate ROS, while vascular endothelial growth factor (VEGF)-encapsulated RADA16 peptide nanofibers improved the angiogenesis responses for rapid wound healing, thus paving the way to design and orchestrate RADA16\/VEGF\/MnO2@GelMA composite hydrogel. With tailored physicochemical properties and favorable biocompatibility, our in vitro experiments revealed that RADA16\/VEGF\/MnO2@GelMA composite hydrogel enabled the controlled release of the MnO2 nanozyme to restrain excessive collagen deposition and the stimulus of VEGF to enhance vascularization. In the full-thickness skin defect rat model, this composite hydrogel significantly minimized scar formation and triggered functional neovascularization, promoting the scarless wound healing. This innovative RADA16\/VEGF\/MnO2@GelMA composite hydrogel-based therapeutic strategy presents an advanced approach toward scarless wound healing, holding great promise in orchestrating the synergistic effects of scar inhibition and angiogenesis promotion.<\/jats:p>","DOI":"10.1021\/acsami.6c08956","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:26:56Z","timestamp":1788215216000},"page":"47354-47371","source":"Crossref","is-referenced-by-count":0,"title":["Manganese Dioxide Nanozyme-Constituted Composite Hydrogel to Scavenge Reactive Oxygen Species for Scarless Wound Healing"],"prefix":"10.1021","volume":"18","author":[{"given":"Qingtao","family":"Wang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University , , No. 1 Yi Xue Yuan Road , Yuzhong District, ,","place":["Chongqing, China, 400016"]},{"name":"The First Affiliated Hospital of Chongqing Medical University , , No. 1 Yi Xue Yuan Road , Yuzhong District, ,","place":["Chongqing, China, 400016"]},{"name":"Chongqing Municipal Health Commission Key Laboratory of Musculoskeletal Regeneration and Translational Medicine , No. 1 Yi Xue Yuan Road , Yuzhong District, ,","place":["Chongqing, China, 400016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University , , No. 1 Yi Xue Yuan Road , Yuzhong District, ,","place":["Chongqing, China, 400016"]},{"name":"Fengdu General Hospital , , No. 33, Lutang Street , Sanhe Subdistrict, Fengdu, ,","place":["Chongqing, China, 408200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Zhong","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University , , No. 1 Yi Xue Yuan Road , Yuzhong District, ,","place":["Chongqing, China, 400016"]},{"name":"The First Affiliated Hospital of Chongqing Medical University , , No. 1 Yi Xue Yuan Road , Yuzhong District, ,","place":["Chongqing, China, 400016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dichen","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University , , No. 1 Yi Xue Yuan Road , Yuzhong District, ,","place":["Chongqing, China, 400016"]},{"name":"The First Affiliated Hospital of Chongqing Medical University , , No. 1 Yi Xue Yuan Road , Yuzhong District, ,","place":["Chongqing, China, 400016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0402-4734","authenticated-orcid":true,"given":"Yilu","family":"Ni","sequence":"additional","affiliation":[{"name":"Chongqing Medical University , , No. 1 Yi Xue Yuan Road , Yuzhong District, ,","place":["Chongqing, China, 400016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixiong","family":"Yi","sequence":"additional","affiliation":[{"name":"Southwest University , , No. 2, Tiansheng Road , Beibei District, ,","place":["Chongqing, China, 400715"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-9930","authenticated-orcid":true,"given":"Bin","family":"He","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University , , No. 1 Yi Xue Yuan Road , Yuzhong District, ,","place":["Chongqing, China, 400016"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"issue":"8","key":"2026091612073192200_cit1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and molecular mechanisms of skin wound healing","volume":"25","author":"Pe\u00f1a","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"8","key":"2026091612073192200_cit2","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/s41580-024-00716-0","article-title":"Fibroblast and myofibroblast activation in normal tissue repair and fibrosis","volume":"25","author":"Younesi","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"2026091612073192200_cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"49","key":"2026091612073192200_cit4","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202406153","article-title":"A Strategy Involving Microporous Microneedles Integrated with CAR-TREM2-Macrophages for Scar Management by Regulating Fibrotic Microenvironment","volume":"36","author":"Liu","year":"2024","journal-title":"Adv. Mater."},{"issue":"1","key":"2026091612073192200_cit5","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02876-9","article-title":"NIR-II light based combinatorial management of hypertrophic scar by inducing autophagy in fibroblasts","volume":"22","author":"Dong","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"2026091612073192200_cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58987-w","article-title":"A dynamically phase-adaptive regulating hydrogel promotes ultrafast anti-fibrotic wound healing","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"issue":"2","key":"2026091612073192200_cit7","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s40257-022-00744-6","article-title":"Hypertrophic Scars and Keloids: Advances in Treatment and Review of Established Therapies","volume":"24","author":"Frech","year":"2023","journal-title":"Am. J. Clin. Dermatol."},{"key":"2026091612073192200_cit8","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jmst.2024.04.046","article-title":"3D-printed biomimetic scaffold with liposome-encapsulated SB431542 promotes scarless wound healing","volume":"208","author":"Liu","year":"2025","journal-title":"J. Mater. Sci. Technol."},{"issue":"38","key":"2026091612073192200_cit9","doi-asserted-by":"publisher","first-page":"50305","DOI":"10.1021\/acsami.4c09890","article-title":"Advanced Wound Healing and Scar Reduction Using an Innovative Anti-ROS Polysaccharide Hydrogel with Recombinant Human Collagen Type III","volume":"16","author":"Zhang","year":"2024","journal-title":"Acs Appl. Mater. Interfaces"},{"key":"2026091612073192200_cit10","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.addr.2019.03.006","article-title":"Drug therapies and delivery mechanisms to treat perturbed skin wound healing","volume":"149\u2013150","author":"Chin","year":"2019","journal-title":"Adv. Drug Delivery Rev."},{"issue":"265","key":"2026091612073192200_cit11","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"23","key":"2026091612073192200_cit12","doi-asserted-by":"publisher","first-page":"6646","DOI":"10.1002\/anie.201600868","article-title":"Self-Assembly of Multi-nanozymes to Mimic an Intracellular Antioxidant Defense System","volume":"55","author":"Huang","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026091612073192200_cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.113990","article-title":"A novel cell-based electrochemical biosensor based on MnO(2) catalysis for antioxidant activity evaluation of anthocyanins","volume":"202","author":"Ye","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"2026091612073192200_cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121597","article-title":"Promoting the healing of infected diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties","volume":"286","author":"Tu","year":"2022","journal-title":"Biomaterials"},{"issue":"4","key":"2026091612073192200_cit15","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1021\/acs.nanolett.2c04774","article-title":"Light-Activated Chemically Reactive Fibrous Patch Revolutionizes Wound Repair Through the Prevention of Postoperative Adhesion","volume":"23","author":"Wu","year":"2023","journal-title":"Nano Lett."},{"key":"2026091612073192200_cit16","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401619","article-title":"A Multifunctional Nanocomposite Hydrogel Delivery System Based on Dual-Loaded Liposomes for Scarless Wound Healing","author":"Xing","year":"2024","journal-title":"Adv. Healthcare Mater."},{"issue":"1","key":"2026091612073192200_cit17","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-023-00422-6","article-title":"GelMA-based bioactive hydrogel scaffolds with multiple bone defect repair functions: therapeutic strategies and recent advances","volume":"27","author":"Zhou","year":"2023","journal-title":"Biomater. Res."},{"key":"2026091612073192200_cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.172158","article-title":"JUN inhibitor T5224-encapsulated RADA16\/bFGF@GelMA multifunctional composite hydrogel for scarless wound healing","volume":"527","author":"Chen","year":"2026","journal-title":"Chem. Eng. J."},{"key":"2026091612073192200_cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123414","article-title":"Metal-polyphenol nanocomposite hybrid hydrogel: A multifunctional platform for treating diabetic foot ulcers through metabolic microenvironment reprogramming","volume":"322","author":"Gong","year":"2025","journal-title":"Biomaterials"},{"issue":"11","key":"2026091612073192200_cit20","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1089\/wound.2014.0594","article-title":"Chemokine Regulation of Angiogenesis During Wound Healing","volume":"4","author":"Bodnar","year":"2015","journal-title":"Adv. Wound Care"},{"issue":"2","key":"2026091612073192200_cit21","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1021\/acsami.0c18388","article-title":"Mussel-Inspired Surface Immobilization of Heparin on Magnetic Nanoparticles for Enhanced Wound Repair via Sustained Release of a Growth Factor and M2 Macrophage Polarization","volume":"13","author":"Wu","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026091612073192200_cit22","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.actbio.2019.10.004","article-title":"In situ formed anti-inflammatory hydrogel loading plasmid DNA encoding VEGF for burn wound healing","volume":"100","author":"Wang","year":"2019","journal-title":"Acta Biomater."},{"key":"2026091612073192200_cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.110469","article-title":"bFGF-incorporated composite biomaterial for bone regeneration","author":"He","year":"2022","journal-title":"Mater. Design"},{"key":"2026091612073192200_cit24","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.msec.2016.12.042","article-title":"Designer bFGF-incorporated d-form self-assembly peptide nanofiber scaffolds to promote bone repair","volume":"74","author":"He","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"2026091612073192200_cit25","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.carbpol.2017.02.059","article-title":"Self-crosslinking and injectable hyaluronic acid\/RGD-functionalized pectin hydrogel for cartilage tissue engineering","volume":"166","author":"Chen","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"2026091612073192200_cit26","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.actbio.2022.07.042","article-title":"Mechanomodulatory biomaterials prospects in scar prevention and treatment","volume":"150","author":"Fernandes","year":"2022","journal-title":"Acta Biomater."},{"key":"2026091612073192200_cit27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.addr.2018.09.010","article-title":"Therapeutic strategies for enhancing angiogenesis in wound healing","volume":"146","author":"Veith","year":"2019","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026091612073192200_cit28","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202503944","article-title":"Mechanisms of MOF-Based Biomaterials in Skin Wound Healing: Antibacterial, Immunomodulatory, Angiogenic, and Neurogenic Effects","author":"Zhou","year":"2025","journal-title":"Adv. Healthcare Mater."},{"issue":"3","key":"2026091612073192200_cit29","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202425109","article-title":"A Strategy for Diabetic Wound Healing: Electrostatic Adsorption of Structural Stability Drugs with Antibacterial, Anti-inflammatory, and Angiogenic Effects","volume":"36","author":"Chen","year":"2026","journal-title":"Adv. Funct. Mater."},{"issue":"4","key":"2026091612073192200_cit30","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202514562","article-title":"Polymeric Skin Booster with Moderate Collagen Regeneration","volume":"36","author":"Zhang","year":"2026","journal-title":"Adv. Funct. Mater."},{"issue":"8","key":"2026091612073192200_cit31","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9081014","article-title":"Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation","volume":"9","author":"Yan","year":"2021","journal-title":"Biomedicines"},{"key":"2026091612073192200_cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125906","article-title":"Mesoporous polydopamine based biominetic nanodrug ameliorates liver fibrosis via antioxidation and TGF-\u03b2\/SMADS pathway","volume":"248","author":"Tang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"2026091612073192200_cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01702-9","article-title":"ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGF\u03b2\/SMAD signaling in lung fibroblasts","volume":"9","author":"Wan","year":"2023","journal-title":"Cell Death Discov."},{"key":"2026091612073192200_cit34","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.ijbiomac.2019.08.087","article-title":"Biofunctions of antimicrobial peptide-conjugated alginate\/hyaluronic acid\/collagen wound dressings promote wound healing of a mixed-bacteria-infected wound","volume":"140","author":"Lin","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"22","key":"2026091612073192200_cit35","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201626","article-title":"Biofabrication of Human Skin with Its Appendages","volume":"11","author":"Hosseini","year":"2022","journal-title":"Adv. Healthc. Mater."},{"issue":"4","key":"2026091612073192200_cit36","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1080\/09537104.2019.1663805","article-title":"Evaluation of the in vivo wound healing potential of the lipid fraction from activated platelet-rich plasma","volume":"31","author":"Cakin","year":"2020","journal-title":"Platelets"},{"key":"2026091612073192200_cit37","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbae149","article-title":"Endocytosis-mediated healing: recombinant human collagen type III chain-induced wound healing for scar-free recovery","volume":"12","author":"Jin","year":"2025","journal-title":"Regen. Biomater."},{"issue":"33","key":"2026091612073192200_cit38","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ado9479","article-title":"Sprayable biomimetic double mask with rapid autophasing and hierarchical programming for scarless wound healing","volume":"10","author":"Yang","year":"2024","journal-title":"Sci. Adv."},{"issue":"50","key":"2026091612073192200_cit39","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202407322","article-title":"Programmable Artificial Skins Accomplish Antiscar Healing with Multiple Appendage Regeneration","volume":"36","author":"Xiong","year":"2024","journal-title":"Adv. Mater."},{"issue":"21","key":"2026091612073192200_cit40","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adv9895","article-title":"Mechanoregulative hydrogel facilitates rapid scarless healing by self-adaptive control of wound niche at different stages","volume":"11","author":"Shu","year":"2025","journal-title":"Sci. Adv."},{"issue":"1","key":"2026091612073192200_cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00474-x","article-title":"Scars","volume":"9","author":"Jeschke","year":"2023","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"16","key":"2026091612073192200_cit42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25168776","article-title":"Comprehensive Insights into Keloid Pathogenesis and Advanced Therapeutic Strategies","volume":"25","author":"Kim","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"2026091612073192200_cit43","doi-asserted-by":"publisher","first-page":"9871","DOI":"10.2147\/IJN.S480901","article-title":"The Effects of Mesenchymal Stem Cells-Derived Exosomes on Metabolic Reprogramming in Scar Formation and Wound Healing","volume":"19","author":"Gong","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"2026091612073192200_cit44","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.958381","article-title":"Role of fibroblasts in wound healing and tissue remodeling on Earth and in space","volume":"10","author":"Cialdai","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"2026091612073192200_cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2025.106737","article-title":"Comparative effects of various extracellular vesicle subpopulations derived from clonal mesenchymal stromal cells on cultured fibroblasts in wound healing-related process","volume":"180","author":"Poorkazem","year":"2025","journal-title":"Int. J. Biochem. Cell B"},{"issue":"609","key":"2026091612073192200_cit46","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb3312","article-title":"JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models","volume":"13","author":"Griffin","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"2026091612073192200_cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102715","article-title":"Targeted apoptosis of myofibroblasts by elesclomol inhibits hypertrophic scar formation","volume":"54","author":"Feng","year":"2020","journal-title":"EBioMedicine"},{"issue":"20","key":"2026091612073192200_cit48","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101526","article-title":"Macrophage-Disguised Manganese Dioxide Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Modulating Inflammatory Microenvironment in Acute Ischemic Stroke","volume":"8","author":"Li","year":"2021","journal-title":"Adv. Sci."},{"key":"2026091612073192200_cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119467","article-title":"Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress","volume":"224","author":"Kumar","year":"2019","journal-title":"Biomaterials"},{"issue":"48","key":"2026091612073192200_cit50","doi-asserted-by":"publisher","first-page":"57009","DOI":"10.1021\/acsami.1c18601","article-title":"Biodegradable Hollow Polydopamine@manganese Dioxide as an Oxygen Self-Supplied Nanoplatform for Boosting Chemo-photodynamic Cancer Therapy","volume":"13","author":"Wang","year":"2021","journal-title":"Acs Appl. Mater. Interfaces"},{"issue":"4","key":"2026091612073192200_cit51","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14533","article-title":"Recent advances on 3D-bioprinted gelatin methacrylate hydrogels for tissue engineering in wound healing: A review of current applications and future prospects","volume":"21","author":"Wang","year":"2024","journal-title":"Int. Wound J."},{"issue":"1","key":"2026091612073192200_cit52","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03274-5","article-title":"Multifunctional hydrogel targeting senescence to accelerate diabetic wound healing through promoting angiogenesis","volume":"23","author":"Yang","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"6","key":"2026091612073192200_cit53","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202402236","article-title":"Multifunctional Hydrogel with Photothermal ROS Scavenging and Antibacterial Activity Accelerates Diabetic Wound Healing","volume":"14","author":"Xue","year":"2025","journal-title":"Adv. Healthcare Mater."},{"issue":"1","key":"2026091612073192200_cit54","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02783-z","article-title":"A novel spherical GelMA-HAMA hydrogel encapsulating APET\u00d72 polypeptide and CFIm25-targeting sgRNA for immune microenvironment modulation and nucleus pulposus regeneration in intervertebral discs","volume":"22","author":"Yu","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"2026091612073192200_cit55","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03534-4","article-title":"Curcumin-loaded PLGA microparticles integrated with ZnO\/GelMA hydrogel microneedles for infectious wound healing and reduction of hypertrophic scars","volume":"23","author":"Zhang","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"2026091612073192200_cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2026.139648","article-title":"EPSTI1 inhibitor-encapsulated RADA16@GelMA multifunctional hydrogel for the repair of osteoporotic bone defects","volume":"736","author":"Tao","year":"2026","journal-title":"Colloids Surf., A"},{"issue":"14","key":"2026091612073192200_cit57","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305856","article-title":"Targeting Grancalcin Accelerates Wound Healing by Improving Angiogenesis in Diabetes","volume":"11","author":"Xiang","year":"2024","journal-title":"Adv. Sci."},{"issue":"1","key":"2026091612073192200_cit58","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-03966-z","article-title":"iPSC-derived megakaryocytes and platelets accelerate wound healing and angiogenesis","volume":"15","author":"Kosaka","year":"2024","journal-title":"Stem Cell Res. Ther."},{"issue":"5","key":"2026091612073192200_cit59","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400150","article-title":"Inflammation-Responsive Hydrogel Accelerates Diabetic Wound Healing through Immunoregulation and Enhanced Angiogenesis","volume":"14","author":"He","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"2026091612073192200_cit60","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.actbio.2022.05.018","article-title":"VH298-loaded extracellular vesicles released from gelatin methacryloyl hydrogel facilitate diabetic wound healing by HIF-1\u03b1-mediated enhancement of angiogenesis","volume":"147","author":"Wang","year":"2022","journal-title":"Acta Biomater."},{"issue":"2","key":"2026091612073192200_cit61","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/bjd.13954","article-title":"Cellular and molecular mechanisms of repair in acute and chronic wound healing","volume":"173","author":"Martin","year":"2015","journal-title":"Brit. J. Dermatol."},{"issue":"16","key":"2026091612073192200_cit62","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1016\/j.biomaterials.2004.08.012","article-title":"The effect of functionalized self-assembling peptide scaffolds on human aortic endothelial cell function","volume":"26","author":"Genov\u00e9","year":"2005","journal-title":"Biomaterials"},{"issue":"3","key":"2026091612073192200_cit63","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jconrel.2010.04.026","article-title":"Slow and sustained release of active cytokines from self-assembling peptide scaffolds","volume":"145","author":"Gelain","year":"2010","journal-title":"J. Control. Release"},{"key":"2026091612073192200_cit64","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.msec.2018.04.063","article-title":"Biofunctionalized peptide nanofiber-based composite scaffolds for bone regeneration","volume":"90","author":"He","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"2026091612073192200_cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2021.110231","article-title":"Controllable release of vascular endothelial growth factor (VEGF) by wheel spinning alginate\/silk fibroin fibers for wound healing","volume":"212","author":"Song","year":"2021","journal-title":"Mater. Design"},{"issue":"5","key":"2026091612073192200_cit66","doi-asserted-by":"publisher","DOI":"10.3390\/gels10050333","article-title":"The MnO2\/GelMA Composite Hydrogels Improve the ROS Microenvironment of Annulus Fibrosus Cells by Promoting the Antioxidant and Autophagy through the SIRT1\/NRF2 Pathway","volume":"10","author":"Xu","year":"2024","journal-title":"Gels"},{"issue":"1","key":"2026091612073192200_cit67","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1128\/MMBR.00015-10","article-title":"Oxidative stress resistance in Deinococcus radiodurans","volume":"75","author":"Slade","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"11","key":"2026091612073192200_cit68","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1111\/cns.13929","article-title":"Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGF\u03b2\/SMADs signaling pathway","volume":"28","author":"Jin","year":"2022","journal-title":"CNS Neurosci. Ther."}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c08956","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/35\/47354\/67394758\/am-2026-08956y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/35\/47354\/67394758\/am-2026-08956y.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:49:15Z","timestamp":1789577355000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/18\/35\/47354\/5328349\/Manganese-Dioxide-Nanozyme-Constituted-Composite"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":68,"journal-issue":{"issue":"35","published-online":{"date-parts":[[2026,8,25]]},"published-print":{"date-parts":[[2026,9,9]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.6c08956","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]}}}