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We developed a biodegradable, redox-responsive polyaminoglycoside nanocarrier (SS-HPT) to improve dsRNA stability, cellular uptake, and intracellular release. SS-HPT readily formed stable nanocomplexes (\u223c300 nm, positively charged) that resisted nuclease degradation under simulated gut conditions and remained stable during storage. Fluorescence imaging demonstrated efficient uptake and widespread distribution in mosquito larvae. Intracellular disulfide cleavage promoted dsRNA release, enhancing gene silencing. Delivery of \u03b2-tubulin-targeting dsRNA via SS-HPT resulted in over 95% larval mortality at substantially lower doses than unprotected dsRNA. These findings establish SS-HPT as an effective platform for RNAi-based pest management.<\/jats:p>","DOI":"10.1021\/acsami.6c09313","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:02:07Z","timestamp":1790697727000},"page":"54400-54413","source":"Crossref","is-referenced-by-count":0,"title":["Breaking Barriers to Mosquito RNAi Control: A dsRNA Biomanufacturing and Nanodelivery Platform for Sustainable Vector Management"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1918-5578","authenticated-orcid":true,"given":"Kai","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongdan","family":"Bi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing University of Chemical Technology , , ,","place":["Beijing, China, 100029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xing","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Wu","sequence":"additional","affiliation":[{"name":"Guizhou Medical University , , ,","place":["Guian New Area, China, 561113"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6021-7151","authenticated-orcid":true,"given":"Jie","family":"Shen","sequence":"additional","affiliation":[{"name":"China Agricultural University , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing University of Chemical Technology , , ,","place":["Beijing, China, 100029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity , ,","place":["Beijing, China, 100071"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"2","key":"2026101404065818400_cit1","first-page":"13","article-title":"Globally Connected and Universally at Risk: Mosquito-Borne Diseases in the 21st Century","volume":"45","author":"Parnell","year":"2024","journal-title":"Emerg. 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