{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:19:02Z","timestamp":1783516742971,"version":"3.55.0"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"26","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2021Y0002"],"award-info":[{"award-number":["2021Y0002"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J01041"],"award-info":[{"award-number":["2024J01041"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720240112"],"award-info":[{"award-number":["20720240112"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["82273872"],"award-info":[{"award-number":["82273872"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["92061119"],"award-info":[{"award-number":["92061119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Appl. Mater. Interfaces"],"published-print":{"date-parts":[[2026,7,8]]},"DOI":"10.1021\/acsami.6c09467","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:54:03Z","timestamp":1782291243000},"page":"36655-36667","source":"Crossref","is-referenced-by-count":0,"title":["Aptamer-Functionalized Liposome Delivery System Based on Multifunctional Microreactor Design"],"prefix":"10.1021","volume":"18","author":[{"given":"Jiaqi","family":"Guo","sequence":"first","affiliation":[{"name":"Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology","place":["Xiamen, China"]},{"name":"The Fifth Hospital of Xiamen","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-5580","authenticated-orcid":true,"given":"Bing","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Environmental Science and Engineering\/Sino-Canada Joint R&D Centre for Water and Environmental Safety","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Peng","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannan","family":"Wu","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyao","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Molecular Imaging and Translational Medicine, School of Public Health","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiji","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Laboratory Medical","place":["Changsha, China"]},{"name":"Changsha Medical University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3573-5520","authenticated-orcid":true,"given":"Dengyue","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences","place":["Xiamen, China"]},{"name":"Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.11.016"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.73"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/35021093"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2019.101074"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.2147\/bctt.s432526"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2018.03.002"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00137"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.2174\/138920009790274540"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21903"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11030229"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2571(00)00013-3"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00457"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26195905"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s10311-018-00841-1"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.037"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.108"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.03.020"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-018-0587-4"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.113109"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00248-5"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/bc0255182"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2018.03.008"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.04.025"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.145125"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics18010011"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.603039"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.09.012"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1055\/a-2795-7008"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202203033"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14010141"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-024-00977-6"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c00600"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1039\/D3LC00821E"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.2174\/1381612828666220211153931"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1039\/D4LC00184B"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ad5d19"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187962"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c15613"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c05057"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.26599\/NR.2025.94907713"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125973"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/D3LC00821E"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3390\/mi11121050"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.07.002"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/nn901676x"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.5b02891"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2011.07.013"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c05489"}],"container-title":["ACS Applied Materials & Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c09467","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c09467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:50:43Z","timestamp":1783515043000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.6c09467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":51,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2026,7,8]]}},"alternative-id":["10.1021\/acsami.6c09467"],"URL":"https:\/\/doi.org\/10.1021\/acsami.6c09467","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,24]]}}}