{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:20:01Z","timestamp":1792826401659,"version":"4.5.0"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Edukacji i Nauki","doi-asserted-by":"publisher","award":["SMN\/18\/1755\/2022"],"award-info":[{"award-number":["SMN\/18\/1755\/2022"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2022\/47\/D\/ST5\/01395"],"award-info":[{"award-number":["2022\/47\/D\/ST5\/01395"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Targeted and on-demand drug delivery technologies have attracted considerable interest for personalized cancer therapies. In this study, we developed a UV-crosslinkable and thermo-responsive gelatin methacrylate (GelMa)\u2014poly(N-isopropylacrylamide) (PNIPAM) (G\/P) hybrid hydrogel, integrated with folic acid-functionalized superparamagnetic iron oxide nanoparticles (SPIONs). Differential scanning calorimetry (DSC) and alternating magnetic field (AMF) evaluations confirmed that introducing GelMa modulated the lower critical solution temperature (LCST) to approximately 32 \u00b0C while enabling efficient magnetothermal response. Cyclic compression tests demonstrated superior mechanical properties. The 2.5G\/P hydrogel achieved a compressive strength of 0.06 MPa at 78% strain, outperforming pure GelMa (0.023 MPa) and PNIPAM (0.012 MPa), with the highest modulus of elasticity at both 25 and 37 \u00b0C. In vitro biocompatibility assays using L929 fibroblasts indicated excellent cytocompatibility with &amp;gt;70% viability over 7 days. Furthermore, the hydrogel demonstrated excellent blood compatibility with a hemolysis ratio below 2%, complying with ISO 10993-4 standards. Synergistic reduction in cell viability was observed in human lung adenocarcinoma (NCI-H1975) and fibroblast-like osteosarcoma (MG-63) cell lines when combining drug loading and simulated AMF thermal stimulation. Triggered by hyperthermia at 41 \u00b0C, the hydrogel demonstrated a highly controlled, pulsatile \u2018ON\/OFF\u2019 drug release profile of 5-fluorouracil (5-FU) driven by network shrinkage, achieving a maximum cumulative release of 72.6% over 28 days with a well-defined biphasic kinetic pattern. These results show that this dual-stimuli responsive hydrogel is a mechanically robust, highly efficient platform for controlled cancer therapy.<\/jats:p>","DOI":"10.1021\/acsami.6c10083","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T14:01:43Z","timestamp":1786284103000},"page":"44458-44472","source":"Crossref","is-referenced-by-count":1,"title":["Multifunctional Magnetothermo-Responsive Smart Hydrogel for On-Demand Controlled Drug Release in Cancer Therapy"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9168-3932","authenticated-orcid":true,"given":"Zahra","family":"Moazzami Goudarzi","sequence":"first","affiliation":[{"name":"Institute of Fundamental Technological Research, Polish Academy of Sciences , , Pawi\u0144skiego 5b , ,","place":["Warsaw, Poland, 02-106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0528-6260","authenticated-orcid":true,"given":"Sohrab","family":"Asgaran","sequence":"additional","affiliation":[{"name":"Helmaco Sp. Z o.o. Company , Ostrobramska 101\/335K , ,","place":["Warszawa, Poland, 04-041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Osial","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Technological Research, Polish Academy of Sciences , , Pawi\u0144skiego 5b , ,","place":["Warsaw, Poland, 02-106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2350-1396","authenticated-orcid":true,"given":"Njemuwa","family":"Nwaji","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Technological Research, Polish Academy of Sciences , , Pawi\u0144skiego 5b , ,","place":["Warsaw, Poland, 02-106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Ko\u0142buk","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Technological Research, Polish Academy of Sciences , , Pawi\u0144skiego 5b , ,","place":["Warsaw, Poland, 02-106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkadiusz","family":"Gradys","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Technological Research, Polish Academy of Sciences , , Pawi\u0144skiego 5b , ,","place":["Warsaw, Poland, 02-106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4968-4429","authenticated-orcid":true,"given":"Bartlomiej","family":"Kalaska","sequence":"additional","affiliation":[{"name":"Medical University of Bialystok , , Mickiewicza 2c , ,","place":["Bialystok, Poland, 15-089"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1920-9715","authenticated-orcid":true,"given":"Olga","family":"Urbanek","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Technological Research, Polish Academy of Sciences , , Pawi\u0144skiego 5b , ,","place":["Warsaw, Poland, 02-106"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4092-9853","authenticated-orcid":true,"given":"Pawe\u0142","family":"Sajkiewicz","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Technological Research, Polish Academy of Sciences , , Pawi\u0144skiego 5b , ,","place":["Warsaw, Poland, 02-106"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"2026081907191012900_cit1","author":"National Cancer Institute","year":"2024","journal-title":"SEER Cancer Statistics AC:FSEER Cancer Statistics Factsheets: Common Cancer Sitesactsheets: Common Cancer Sites"},{"key":"2026081907191012900_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123180","article-title":"Challenges and Material Innovations in Drug Delivery to Central Nervous System Tumors","volume":"319","author":"Gong","year":"2025","journal-title":"Biomaterials"},{"key":"2026081907191012900_cit3","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/J.IJBIOMAC.2022.06.138","article-title":"Control of Drug Release from Cotton Fabric by Nanofibrous Mat","volume":"217","author":"Goudarzi","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"2026081907191012900_cit4","doi-asserted-by":"publisher","first-page":"5502","DOI":"10.1039\/d3bm00837a","article-title":"A Facile One-Stone-Two-Birds Strategy for Fabricating Multifunctional 3D Nanofibrous Scaffolds","author":"Amarjargal","year":"2023","journal-title":"Biomater. Sci."},{"issue":"29","key":"2026081907191012900_cit5","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705328","article-title":"Advances in Biomaterials for Drug Delivery","volume":"30","author":"Fenton","year":"2018","journal-title":"Adv. Mater."},{"key":"2026081907191012900_cit6","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/9783527837021.ch4","volume-title":"Chemical Physics of Polymer Nanocomposites: Processing, Morphology, Structure, Thermodynamics, Rheology","author":"Sharifianjazi"},{"issue":"2","key":"2026081907191012900_cit7","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s00289-019-02756-5","article-title":"Structural and Mechanical Properties of Fibrous Poly (Caprolactone)\/Gelatin Nanocomposite Incorporated with Cellulose Nanofibers","volume":"77","author":"Moazzami Goudarzi","year":"2020","journal-title":"Polym. Bull."},{"key":"2026081907191012900_cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2020.123313","article-title":"An Investigation into Influence of Acetylated Cellulose Nanofibers on Properties of PCL\/Gelatin Electrospun Nanofibrous Scaffold for Soft Tissue Engineering","volume":"213","author":"Moazzami Goudarzi","year":"2021","journal-title":"Polymer (Guildf)."},{"issue":"2","key":"2026081907191012900_cit9","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/00405000.2019.1633216","article-title":"Proceeding toward the Development of Poly(\u025b-Caprolactone)\/Cellulose Microfibrils Electrospun Biocomposites Using a Novel Ternary Solvent System","volume":"111","author":"Zolfagharlou Kouhi","year":"2020","journal-title":"J. Text. Inst."},{"key":"2026081907191012900_cit10","doi-asserted-by":"publisher","first-page":"8835","DOI":"10.1021\/acs.chemrev.5c00182","article-title":"Therapeutic Hydrogels: Properties and Biomedical Applications","author":"Dong","year":"2025","journal-title":"Chem. Rev."},{"key":"2026081907191012900_cit11","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1021\/acspolymersau.5c00053","article-title":"Smart Polymer-Derived Injectable Hydrogels: Current Status and Future Perspectives","author":"Maity","year":"2025","journal-title":"ACS Polym. Au"},{"issue":"5","key":"2026081907191012900_cit12","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.12693\/APhysPolA.125.1236","article-title":"Stimuli-Responsive PNIPAM Based Copolymers: Modeling and Light Scattering Investigations","volume":"125","author":"\u015aliwa","year":"2014","journal-title":"Acta Phys. Pol., A"},{"key":"2026081907191012900_cit13","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ijbiomac.2016.02.042","article-title":"Temperature, PH and Redox Responsive Cellulose Based Hydrogels for Protein Delivery","volume":"87","author":"Dutta","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"2026081907191012900_cit14","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1021\/nl2011627","article-title":"nanohybrids\u201d Based on PH-Responsive Hydrogels and Inorganic Nanoparticles for Drug Delivery and Sensor Applications","volume":"11","author":"Riedinger","year":"2011","journal-title":"Nano Lett."},{"issue":"1","key":"2026081907191012900_cit15","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16010093","article-title":"Electrospun Antimicrobial Drug Delivery Systems and Hydrogels Used for Wound Dressings","volume":"16","author":"Moazzami Goudarzi","year":"2024","journal-title":"Pharmaceutics"},{"key":"2026081907191012900_cit16","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1146\/annurev-bioeng-060418-052324","article-title":"Programming Stimuli-Responsive Behavior into Biomaterials","volume":"21","author":"Badeau","year":"2019","journal-title":"Annu. Rev. Biomed. Eng."},{"issue":"14","key":"2026081907191012900_cit17","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1039\/c5sm00026b","article-title":"Comparison of LCST-Transitions of Homopolymer Mixture, Diblock and Statistical Copolymers of NIPAM and VCL in Water","volume":"11","author":"Hou","year":"2015","journal-title":"Soft Matter"},{"issue":"3","key":"2026081907191012900_cit18","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1021\/ma302320y","article-title":"Rationalizing Polymer Swelling and Collapse under Attractive Cosolvent Conditions","volume":"46","author":"Heyda","year":"2013","journal-title":"Macromolecules"},{"key":"2026081907191012900_cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2021.105150","article-title":"Effect of the Macromolecular Architecture on the Thermoresponsive Behavior of Poly(N-Isopropylacrylamide) in Copolymers with Poly(N,N-Dimethylacrylamide) in Aqueous Solutions: Block vs Random Copolymers","volume":"171","author":"Zhang","year":"2022","journal-title":"React. Funct. Polym."},{"issue":"19","key":"2026081907191012900_cit20","doi-asserted-by":"publisher","DOI":"10.3390\/polym14194128","article-title":"Thermo-Sensitive Poly (N-Isopropylacrylamide-Co-Polyacrylamide) Hydrogel for PH-Responsive Therapeutic Delivery","volume":"14","author":"Santhamoorthy","year":"2022","journal-title":"Polymers (Basel)."},{"issue":"4","key":"2026081907191012900_cit21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1208\/s12249-020-01672-6","article-title":"In Vitro Release of 5-Fluorouracil and Methotrexate from Different Thermosensitive Chitosan Hydrogel Systems","volume":"21","author":"Mohammed","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"2026081907191012900_cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118434","article-title":"Curcumin-Incorporated Crosslinked Sodium Alginate-g-Poly (N-Isopropyl Acrylamide) Thermo-Responsive Hydrogel as an in-Situ Forming Injectable Dressing for Wound Healing: In Vitro Characterization and in Vivo Evaluation","volume":"271","author":"Zakerikhoob","year":"2021","journal-title":"Carbohydr. Polym."},{"issue":"1 SPEC. ISS.","key":"2026081907191012900_cit23","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jmmm.2006.10.1201","article-title":"Layer-by-Layer Assembly of a Magnetic Nanoparticle Shell on a Thermoresponsive Microgel Core","volume":"311","author":"Wong","year":"2007","journal-title":"J. Magn. Magn. Mater."},{"issue":"27","key":"2026081907191012900_cit24","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202102685","article-title":"Fabrication of Thermoresponsive Hydrogel Scaffolds with Engineered Microscale Vasculatures","volume":"31","author":"Li","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"2026081907191012900_cit25","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.bioactmat.2024.04.032","article-title":"Strategies of Functionalized GelMA-Based Bioinks for Bone Regeneration: Recent Advances and Future Perspectives","volume":"38","author":"Zhu","year":"2024","journal-title":"Bioact. Mater."},{"issue":"31","key":"2026081907191012900_cit26","doi-asserted-by":"publisher","first-page":"17737","DOI":"10.1039\/c9ra02695a","article-title":"Gelatin Methacryloyl (GelMA)-Based Biomaterials for Bone Regeneration","volume":"9","author":"Dong","year":"2019","journal-title":"RSC Adv."},{"issue":"12","key":"2026081907191012900_cit27","doi-asserted-by":"publisher","DOI":"10.3390\/polym10121317","article-title":"Smart Shear-Thinning Hydrogels as Injectable Drug Delivery Systems","volume":"10","author":"Samimi Gharaie","year":"2018","journal-title":"Polymers (Basel)"},{"issue":"4","key":"2026081907191012900_cit28","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1021\/acs.biomac.3c00279","article-title":"Leveraging the Recent Advancements in GelMA Scaffolds for Bone Tissue Engineering: An Assessment of Challenges and Opportunities","volume":"25","author":"Mamidi","year":"2024","journal-title":"Biomacromolecules"},{"issue":"4","key":"2026081907191012900_cit29","doi-asserted-by":"publisher","first-page":"5798","DOI":"10.1021\/acsami.2c18961","article-title":"A Biomimetic Bilayer Hydrogel Actuator Based on Thermoresponsive Gelatin Methacryloyl-Poly(N-Isopropylacrylamide) Hydrogel with Three-Dimensional Printability","volume":"15","author":"Huang","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026081907191012900_cit30","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202400635","article-title":"Nanoparticle-Embedded GelMA\/NIPAm Hydrogels: A Temperature-Responsive Hybrid System for Controlled Drug Release","volume":"26","author":"Daaboul","year":"2025","journal-title":"Macromol. Biosci."},{"issue":"11","key":"2026081907191012900_cit31","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202311454","article-title":"Magnetic Polymer Microcarriers for Cell Engineering Applications with Enzyme-Free Cell Harvesting and Rapid Recovery in Large-Scale Cell Culture","volume":"34","author":"Liu","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"20","key":"2026081907191012900_cit32","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901280","article-title":"Photoresponsive Delivery Microcarriers for Tissue Defects Repair","volume":"6","author":"Zhao","year":"2019","journal-title":"Adv. Sci."},{"issue":"36","key":"2026081907191012900_cit33","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202200858","article-title":"Biomimic Trained Immunity-MSCs Delivery Microcarriers for Acute Liver Failure Regeneration","volume":"18","author":"Wang","year":"2022","journal-title":"Small"},{"issue":"29","key":"2026081907191012900_cit34","doi-asserted-by":"publisher","first-page":"7555","DOI":"10.1016\/j.biomaterials.2010.06.030","article-title":"Core-Shell Hybrid Nanogels for Integration of Optical Temperature-Sensing, Targeted Tumor Cell Imaging, and Combined Chemo-Photothermal Treatment","volume":"31","author":"Wu","year":"2010","journal-title":"Biomaterials"},{"issue":"20","key":"2026081907191012900_cit35","doi-asserted-by":"publisher","first-page":"7240","DOI":"10.1039\/c1jm10277j","article-title":"Multifunctional Au@IPN-PNIPAAm Nanogels for Cancer Cell Imaging and Combined Chemo-Photothermal Treatment","volume":"21","author":"Zhao","year":"2011","journal-title":"J. Mater. Chem."},{"issue":"21","key":"2026081907191012900_cit36","doi-asserted-by":"publisher","first-page":"6434","DOI":"10.1021\/la4001957","article-title":"Superparamagnetic Hollow Hybrid Nanogels as a Potential Guidable Vehicle System of Stimuli-Mediated MR Imaging and Multiple Cancer Therapeutics","volume":"29","author":"Chiang","year":"2013","journal-title":"Langmuir"},{"issue":"12","key":"2026081907191012900_cit37","doi-asserted-by":"publisher","first-page":"10315","DOI":"10.1021\/la1004819","article-title":"Acidic PH-Responsive Nanogels as Smart Cargo Systems for the Simultaneous Loading and Release of Short Oligonucleotides and Magnetic Nanoparticles","volume":"26","author":"Deka","year":"2010","journal-title":"Langmuir"},{"key":"2026081907191012900_cit38","doi-asserted-by":"publisher","DOI":"10.3390\/ma12040617","article-title":"Superparamagnetic Iron Oxide Nanoparticles\u2014Current and Prospective Medical Applications","volume":"12","author":"Duli\u0144ska-Litewka","year":"2019","journal-title":"Materials (Basel)"},{"issue":"11","key":"2026081907191012900_cit39","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14112388","article-title":"Superparamagnetic Iron Oxide Nanoparticles for Immunotherapy of Cancers through Macrophages and Magnetic Hyperthermia","volume":"14","author":"Dias","year":"2022","journal-title":"Pharmaceutics"},{"issue":"9","key":"2026081907191012900_cit40","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1007\/s10853-023-08168-1","article-title":"Redox-Responsive Degradable Microgel Modified with Superparamagnetic Nanoparticles Exhibiting Controlled, Hyperthermia-Enhanced Drug Release","volume":"58","author":"Dagdelen","year":"2023","journal-title":"J. Mater. Sci."},{"issue":"10","key":"2026081907191012900_cit41","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1021\/nl9018935","article-title":"A Magnetically Triggered Composite Membrane for On-Demand Drug Delivery","volume":"9","author":"Hoare","year":"2009","journal-title":"Nano Lett."},{"issue":"40","key":"2026081907191012900_cit42","doi-asserted-by":"publisher","first-page":"15379","DOI":"10.1039\/c7nr02327h","article-title":"Injectable Nanoengineered Stimuli-Responsive Hydrogels for on-Demand and Localized Therapeutic Delivery","volume":"9","author":"Jalili","year":"2017","journal-title":"Nanoscale"},{"issue":"3","key":"2026081907191012900_cit43","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1021\/bm301703x","article-title":"Injectable Superparamagnets: Highly Elastic and Degradable Poly(N-Isopropylacrylamide)-Superparamagnetic Iron Oxide Nanoparticle (SPION) Composite Hydrogels","volume":"14","author":"Campbell","year":"2013","journal-title":"Biomacromolecules"},{"issue":"3","key":"2026081907191012900_cit44","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1021\/acsmacrolett.5b00057","article-title":"Enhanced Pulsatile Drug Release from Injectable Magnetic Hydrogels with Embedded Thermosensitive Microgels","volume":"4","author":"Campbell","year":"2015","journal-title":"ACS Macro Lett."},{"issue":"1","key":"2026081907191012900_cit45","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1021\/bm990017d","article-title":"Structural and Rheological Properties of Methacrylamide Modified Gelatin Hydrogels","volume":"1","author":"Bulcke","year":"2000","journal-title":"Biomacromolecules"},{"issue":"1","key":"2026081907191012900_cit46","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/jbm.a.36226","article-title":"Gelatin Methacrylate Scaffold for Bone Tissue Engineering: The Influence of Polymer Concentration","volume":"106","author":"Celikkin","year":"2018","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"4","key":"2026081907191012900_cit47","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1002\/jbm.a.35621","article-title":"Photocrosslinkable and Elastomeric Hydrogels for Bone Regeneration","volume":"104","author":"Thakur","year":"2016","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"5","key":"2026081907191012900_cit48","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.foodres.2005.10.015","article-title":"Quick Dissolvable, Edible and Heatsealable Blend Films Based on Konjac Glucomannan - Gelatin","volume":"39","author":"Li","year":"2006","journal-title":"Food Res. Int."},{"issue":"41","key":"2026081907191012900_cit49","doi-asserted-by":"publisher","first-page":"8838","DOI":"10.1021\/acs.jpcb.9b06125","article-title":"Coil-Globule Transition Thermodynamics of Poly(N-Isopropylacrylamide)","volume":"123","author":"Podewitz","year":"2019","journal-title":"J. Phys. Chem. B"},{"issue":"8","key":"2026081907191012900_cit50","doi-asserted-by":"publisher","DOI":"10.3390\/magnetochemistry8080090","article-title":"Influence of Experimental Conditions during Synthesis on the Physicochemical Properties of the SPION\/Hydroxyapatite Nanocomposite for Magnetic Hyperthermia Application","volume":"8","author":"Thanh","year":"2022","journal-title":"Magnetochemistry"},{"issue":"2","key":"2026081907191012900_cit51","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1007\/s00289-019-02782-3","article-title":"Thermal Characterization by DSC and TGA Analyses of PVA Hydrogels with Organic and Sodium MMT","volume":"77","author":"Reguieg","year":"2020","journal-title":"Polym. Bull."},{"issue":"6","key":"2026081907191012900_cit52","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1118\/1.1748629","article-title":"Description and Characterization of the Novel Hyperthermia- and Thermoablation-System MFH\u00ae300F for Clinical Magnetic Fluid Hyperthermia","volume":"31","author":"Gneveckow","year":"2004","journal-title":"Med. Phys."},{"issue":"8","key":"2026081907191012900_cit53","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1080\/02656736.2018.1430867","article-title":"Magnetic Hyperthermia Therapy for the Treatment of Glioblastoma: A Review of the Therapy\u2019s History, Efficacy and Application in Humans","volume":"34","author":"Mahmoudi","year":"2018","journal-title":"Int. J. Hyperthermia"},{"key":"2026081907191012900_cit54","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2217\/nnm-2021-0348","article-title":"A Review of Recent Advances in Magnetic Nanoparticle-Based Theranostics of Glioblastoma","author":"Dhar","year":"2022","journal-title":"Nanomedicine"},{"issue":"51","key":"2026081907191012900_cit55","doi-asserted-by":"publisher","first-page":"15342","DOI":"10.1002\/anie.201506663","article-title":"Poly(N-Isopropylacrylamide) Phase Diagrams: Fifty Years of Research","volume":"54","author":"Halperin","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081907191012900_cit56","article-title":"Deep Heating Therapy via Microwave Diathermy Relieves Pain and Improves Physical Function in Patients with Knee Osteoarthritis: A Double-Blind Randomized Clinical Trial","volume-title":"Eur. J. Phys. Rehab. Med.","author":"Rabini","year":"2012"},{"issue":"12","key":"2026081907191012900_cit57","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1177\/0269215511400767","article-title":"Short-Term Effects of Local Microwave Hyperthermia on Pain and Function in Patients with Mild to Moderate Carpal Tunnel Syndrome: A Double Blind Randomized Sham-Controlled Trial","volume":"25","author":"Frasca","year":"2011","journal-title":"Clin. Rehabil."},{"key":"2026081907191012900_cit58","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ijsolstr.2019.06.023","article-title":"Programming the Equilibrium Swelling Response of Heterogeneous Polymeric Gels","volume":"178\u2013179","author":"Cohen","year":"2019","journal-title":"Int. J. Solids Struct."},{"issue":"1","key":"2026081907191012900_cit59","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0969-806X(00)00374-1","article-title":"Swelling Kinetics and Stimuli-Responsiveness of Poly(DMAEMA) Hydrogels Prepared by UV-Irradiation","volume":"61","author":"Yanfeng","year":"2001","journal-title":"Radiat. Phys. Chem."},{"issue":"7272","key":"2026081907191012900_cit60","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature08602","article-title":"Designing Materials to Direct Stem-Cell Fate","volume":"462","author":"Lutolf","year":"2009","journal-title":"Nature"},{"key":"2026081907191012900_cit61","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.jphotochem.2018.08.033","article-title":"Effect of Number of Positive Charges on the Photophysical and Photodynamic Therapy Activities of Quarternary Benzothiazole Substituted Zinc Phthalocyanine","volume":"367","author":"Matshitse","year":"2018","journal-title":"J. Photochem. Photobiol. A Chem."},{"issue":"15","key":"2026081907191012900_cit62","first-page":"117","article-title":"Analysis of Model Drug Release Kinetics from Complex Matrices of Polylactide-Chitosan","volume":"XV","author":"Balcerzak","year":"2010","journal-title":"Prog. Chem. Appl. Chitin Deriv."}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c10083","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/32\/44458\/66466367\/am-2026-10083j.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/32\/44458\/66466367\/am-2026-10083j.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:35:46Z","timestamp":1787139346000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/18\/32\/44458\/5250781\/Multifunctional-Magnetothermo-Responsive-Smart"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,9]]},"references-count":62,"journal-issue":{"issue":"32","published-online":{"date-parts":[[2026,8,9]]},"published-print":{"date-parts":[[2026,8,19]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.6c10083","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,9]]}}}