{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:46:04Z","timestamp":1792784764533,"version":"4.5.0"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012692","name":"K. C. Wong Education Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["FRF-BR-23-02B"],"award-info":[{"award-number":["FRF-BR-23-02B"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Municipal Natural Science Foundation","award":["7244518"],"award-info":[{"award-number":["7244518"]}]},{"name":"Beijing Science & Technology New Star Cross Project","award":["20240484705"],"award-info":[{"award-number":["20240484705"]}]},{"name":"Interdisciplinary Research Project for Young Teachers of USTB","award":["FRF-IDRY-24-032"],"award-info":[{"award-number":["FRF-IDRY-24-032"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["52273120"],"award-info":[{"award-number":["52273120"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["82402477"],"award-info":[{"award-number":["82402477"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Proof-of-Concept program of USTB","award":["GNYZ-2024-29"],"award-info":[{"award-number":["GNYZ-2024-29"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>APOE4-driven mitochondrial dysfunction is one of the important primary drivers of cognitive decline in neurodegenerative diseases. However, achieving mitochondrial-targeted drug delivery in the nervous system requires overcoming multiple barriers, necessitating the development of a safer and more efficient bionanoparticle drug delivery system. DNA nanoflowers (DNFs), generated via rolling circle amplification (RCA), offer programmable platforms for creating targeted drug delivery vehicles. Here, we designed a multifunctional DNF surface conjugated with ferrocene groups, loaded with resveratrol, encoded with mitochondrial-targeting aptamers, and coated with neural stem cell membranes (DFRM). In vitro studies demonstrated that DFRM efficiently targeted neuronal mitochondria and mediated ROS-responsive drug release, ameliorating neuronal impairment through robust anti-inflammatory\/antioxidant effects and enhanced mitochondrial biogenesis. Intranasal administration in model mice significantly improved cognitive and memory performance while attenuating key neurodegenerative hallmarks, including mitochondrial damage, blood\u2212brain barrier leakage, and A\u03b2 plaque deposition. The neural stem cell membrane coating enables brain entry and neuronal targeting via homing effects, ferrocene groups confer mitochondria-specific ROS-responsive release, and resveratrol provided therapeutic benefits through anti-inflammatory, antioxidant, and mitochondrial biogenesis-promoting actions. This integrated delivery system synergistically overcame multiple barriers to achieve precise targeting, offering a promising strategy for neurodegenerative disease therapy and prevention.<\/jats:p>","DOI":"10.1021\/acsami.6c10103","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:02:20Z","timestamp":1790240540000},"page":"53102-53120","source":"Crossref","is-referenced-by-count":0,"title":["Membrane-Coated DNA Nanoflowers Attenuate Cognitive Decline in Apolipoprotein E4 Mice"],"prefix":"10.1021","volume":"18","author":[{"given":"Zhongci","family":"Hang","sequence":"first","affiliation":[{"name":"University of Science and Technology Beijing , , ,","place":["Beijing, China, 100083"]},{"name":"University of Science and Technology Beijing , , ,","place":["Beijing, China, 100083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbin","family":"Sun","sequence":"additional","affiliation":[{"name":"University of Science and Technology Beijing , , ,","place":["Beijing, China, 100083"]},{"name":"University of Science and Technology Beijing , , ,","place":["Beijing, China, 100083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanglin","family":"Cai","sequence":"additional","affiliation":[{"name":"University of Science and Technology Beijing , , ,","place":["Beijing, China, 100083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Bian","sequence":"additional","affiliation":[{"name":"University of Science and Technology Beijing , , ,","place":["Beijing, China, 100083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9293-2766","authenticated-orcid":true,"given":"Liping","family":"Zhou","sequence":"additional","affiliation":[{"name":"University of Science and Technology Beijing , , ,","place":["Beijing, China, 100083"]},{"name":"University of Science and Technology Beijing , , ,","place":["Beijing, China, 100083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-4166","authenticated-orcid":true,"given":"Yongqiang","family":"Wen","sequence":"additional","affiliation":[{"name":"University of Science and Technology Beijing , , ,","place":["Beijing, China, 100083"]},{"name":"University of Science and Technology Beijing , , ,","place":["Beijing, China, 100083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0731-4809","authenticated-orcid":true,"given":"Hongwu","family":"Du","sequence":"additional","affiliation":[{"name":"University of Science and Technology Beijing , , ,","place":["Beijing, China, 100083"]},{"name":"University of Science and Technology Beijing , , ,","place":["Beijing, China, 100083"]},{"name":"University of Science and Technology Beijing , , ,","place":["Beijing, China, 100083"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"2026100711084763500_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102307","article-title":"The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases","volume":"97","author":"Zhang","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"10","key":"2026100711084763500_cit2","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1080\/15548627.2022.2094605","article-title":"Mitochondrial quality control links two seemingly unrelated neurodegenerative diseases","volume":"18","author":"Tang","year":"2022","journal-title":"Autophagy"},{"issue":"2","key":"2026100711084763500_cit3","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.70050","article-title":"Nanomaterial-based immune therapeutic strategies in neurodegenerative diseases","volume":"4","author":"Zhou","year":"2025","journal-title":"BMEMat"},{"key":"2026100711084763500_cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2026.114644","article-title":"Multifunctional DNA nanoflower recruits neural stem cells via ROS-responsive extracellular drug release to promote neurogenesis","volume":"392","author":"Hang","year":"2026","journal-title":"J. Control. Release"},{"key":"2026100711084763500_cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123970","article-title":"Carrier-free nanoassembly with dual antioxidant and anti-inflammatory activities camouflaged by melanoma cell membrane for tau-targeted therapy of Alzheimer's disease","volume":"329","author":"Xue","year":"2026","journal-title":"Biomaterials"},{"key":"2026100711084763500_cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2026.114896","article-title":"Engineered microglial membrane-coated polydopamine-based nanomedicine for precise treatment of Alzheimer's disease","volume":"394","author":"Huang","year":"2026","journal-title":"J. Control. Release"},{"issue":"51","key":"2026100711084763500_cit7","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202505187","article-title":"Natural Cell-Inspired Nanoparticles: Preparation, Mechanisms, Applications, and Prospects for Clinical Translation","volume":"37","author":"Li","year":"2025","journal-title":"Adv. Mater."},{"issue":"5","key":"2026100711084763500_cit8","doi-asserted-by":"publisher","first-page":"4414","DOI":"10.1021\/acsnano.2c09752","article-title":"An Antisense Oligonucleotide-Loaded Blood-Brain Barrier Penetrable Nanoparticle Mediating Recruitment of Endogenous Neural Stem Cells for the Treatment of Parkinson's Disease","volume":"17","author":"Sun","year":"2023","journal-title":"ACS Nano"},{"key":"2026100711084763500_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101800","article-title":"Hybrid stem cell-derived bioresponsive vesicles for effective inflamed blood-brain barrier targeting delivery","volume":"49","author":"Wu","year":"2023","journal-title":"Nano Today"},{"issue":"33","key":"2026100711084763500_cit10","doi-asserted-by":"publisher","first-page":"47497","DOI":"10.1021\/acsami.5c09843","article-title":"Engineered Stem Cell Membrane-Coated Nanodrugs for Targeted Therapy of Alzheimer's Disease","volume":"17","author":"Sha","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"10","key":"2026100711084763500_cit11","doi-asserted-by":"publisher","first-page":"7950","DOI":"10.1007\/s12035-024-04088-6","article-title":"Andrographolide Improves ApoE4-Mediated Blood-Brain Barrier Injury by Alleviating Inflammation","volume":"61","author":"Zhou","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"2026100711084763500_cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.102070","article-title":"The blood-brain barrier, a key bridge to treat neurodegenerative diseases","volume":"91","author":"Hang","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"4","key":"2026100711084763500_cit13","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.14336\/AD.2025.0675","article-title":"VCAM-1 in Cognitive Impairment: Mechanisms, Biomarker Potential, and Therapeutic Targeting","volume":"17","author":"Guan","year":"2025","journal-title":"Aging Dis."},{"issue":"35","key":"2026100711084763500_cit14","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201902011","article-title":"Targeted Drug Delivery to Stroke via Chemotactic Recruitment of Nanoparticles Coated with Membrane of Engineered Neural Stem Cells","volume":"15","author":"Ma","year":"2019","journal-title":"Small"},{"issue":"3","key":"2026100711084763500_cit15","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.cell.2012.01.032","article-title":"Finding a target for resveratrol","volume":"148","author":"Tennen","year":"2012","journal-title":"Cell"},{"issue":"4","key":"2026100711084763500_cit16","doi-asserted-by":"publisher","first-page":"6144","DOI":"10.1021\/acsami.4c21260","article-title":"Facile Formulation of a Resveratrol-Mediated Multibond Network Hydrogel with Efficient Sustainable Antibacterial, Reactive Oxygen Species Scavenging, Pro-Angiogenesis, and Immunomodulation Activities for Accelerating Infected Wound Healing","volume":"17","author":"Feng","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"2026100711084763500_cit17","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.cmet.2012.04.016","article-title":"Fortifying the link between SIRT1, resveratrol, and mitochondrial function","volume":"15","author":"Denu","year":"2012","journal-title":"Cell Metab."},{"issue":"52","key":"2026100711084763500_cit18","doi-asserted-by":"publisher","first-page":"70516","DOI":"10.1021\/acsami.5c19661","article-title":"A Tetrahedral DNA Framework-Based Mitochondrial Anchoring System Promotes Diabetic Wound Healing via Mitophagy and Mitostress Regulation","volume":"17","author":"Yao","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026100711084763500_cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119844","article-title":"Neuronal mitochondria-targeted micelles relieving oxidative stress for delayed progression of Alzheimer's disease","volume":"238","author":"Yang","year":"2020","journal-title":"Biomaterials"},{"issue":"11","key":"2026100711084763500_cit20","doi-asserted-by":"publisher","first-page":"4822","DOI":"10.7150\/thno.42387","article-title":"SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"issue":"1","key":"2026100711084763500_cit21","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1080\/10717544.2020.1745328","article-title":"Neuronal mitochondria-targeted therapy for Alzheimer's disease by systemic delivery of resveratrol using dual-modified novel biomimetic nanosystems","volume":"27","author":"Han","year":"2020","journal-title":"Drug Deliv."},{"key":"2026100711084763500_cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114763","article-title":"In-situ bio-assembled specific Au NCs-Aptamer-Pyro conjugates nanoprobe for tumor imaging and mitochondria-targeted photodynamic therapy","volume":"218","author":"Xiong","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"7","key":"2026100711084763500_cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02776-4","article-title":"Altered mitochondrial dynamics and function in APOE4-expressing astrocytes","volume":"11","author":"Schmukler","year":"2020","journal-title":"Cell Death Dis."},{"key":"2026100711084763500_cit24","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-16","article-title":"ApoE4 induces A\u03b242, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice","volume":"8","author":"Liraz","year":"2013","journal-title":"Mol. Neurodegener."},{"issue":"10","key":"2026100711084763500_cit25","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1038\/nprot.2015.078","article-title":"Preparation and biomedical applications of programmable and multifunctional DNA nanoflowers","volume":"10","author":"Lv","year":"2015","journal-title":"Nat. Protoc."},{"key":"2026100711084763500_cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.100965","article-title":"Multifunctional bioreactive-nanoconstructs for sensitive and accurate MRI of cerebrospinal fluid pathology and intervention of Alzheimer\u2019s disease","volume":"35","author":"He","year":"2020","journal-title":"Nano Today"},{"issue":"4S_Part_14","key":"2026100711084763500_cit27","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.jalz.2009.04.1016","article-title":"P3-243: The role for CSF dynabridging studies in developing new therapies for Alzheimer\u2019s disease","volume":"5","author":"Ereshefsky","year":"2009","journal-title":"Alzheimer's Dementia"},{"issue":"S12","key":"2026100711084763500_cit28","doi-asserted-by":"publisher","DOI":"10.1002\/alz.074171","article-title":"Genome-wide analysis identifies APOE4 as a strong mitophagy modifier in Lewy body disease","volume":"19","author":"Hou","year":"2023","journal-title":"Alzheimer\u2019s Dementia"},{"issue":"1","key":"2026100711084763500_cit29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13578-021-00563-y","article-title":"ApoE4 (\u0394272-299) induces mitochondrial-associated membrane formation and mitochondrial impairment by enhancing GRP75-modulated mitochondrial calcium overload in neuron","volume":"11","author":"Tao","year":"2021","journal-title":"Cell Biosci."},{"issue":"7","key":"2026100711084763500_cit30","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18160","article-title":"ApoE4 dysregulation incites depressive symptoms and mitochondrial impairments in mice","volume":"28","author":"Li","year":"2024","journal-title":"J. Cell. Mol. Med."},{"issue":"S24","key":"2026100711084763500_cit31","doi-asserted-by":"publisher","DOI":"10.1002\/alz.082765","article-title":"Lithium protects against ApoE4 mediated calcium dysregulation and mitochondrial dysfunction and cell damage in iPSCs from a sporadic Alzheimer\u2019s disease patient","volume":"19","author":"Liang","year":"2023","journal-title":"Alzheimer's Dementia"},{"issue":"2","key":"2026100711084763500_cit32","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41583-023-00776-9","article-title":"Cell type-specific roles of APOE4 in Alzheimer disease","volume":"25","author":"Blumenfeld","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"key":"2026100711084763500_cit33","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1002\/mds.30324","article-title":"Loss of ANK3 Function Causes a Recessive Neurodevelopmental Disorder with Cerebellar Ataxia","volume":"40","author":"Maroofian","year":"2025","journal-title":"Mov. Disord."},{"issue":"3","key":"2026100711084763500_cit34","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s43587-023-00368-3","article-title":"Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits","volume":"3","author":"Koutsodendris","year":"2023","journal-title":"Nat. Aging"},{"issue":"1","key":"2026100711084763500_cit35","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02773-1","article-title":"Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse model","volume":"22","author":"Junjie","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"2026100711084763500_cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.102123","article-title":"Factors affecting the GABAergic synapse function in Alzheimer's disease: Focus on microRNAs","volume":"92","author":"Rivera","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"2026100711084763500_cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-019-0091-4","article-title":"MKP-1 reduces A\u03b2 generation and alleviates cognitive impairments in Alzheimer's disease models","volume":"4","author":"Du","year":"2019","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"2026100711084763500_cit38","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1287-1","article-title":"Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2","volume":"15","author":"Zhou","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"2026100711084763500_cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104466","article-title":"Differential effects of MEK inhibitors on rat neural stem cell differentiation: Repressive roles of MEK2 in neurogenesis and induction of astrocytogenesis by PD98059","volume":"149","author":"Lee","year":"2019","journal-title":"Pharmacol. Res."},{"key":"2026100711084763500_cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107778","article-title":"Ferroportin 1 depletion in neural stem cells promotes hippocampal neurogenesis and cognitive function in mice","volume":"216","author":"Ding","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"2","key":"2026100711084763500_cit41","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.254","article-title":"Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs","volume":"50","author":"Koo","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"2026100711084763500_cit42","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-016-0117-0","article-title":"Activation of Wnt signaling promotes hippocampal neurogenesis in experimental autoimmune encephalomyelitis","volume":"11","author":"Schneider","year":"2016","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"2026100711084763500_cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07302-x","article-title":"Wnt\/\u03b2-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling","volume":"9","author":"H\u00fcbner","year":"2018","journal-title":"Nat. Commun."},{"issue":"S13","key":"2026100711084763500_cit44","doi-asserted-by":"publisher","DOI":"10.1002\/alz.076474","article-title":"Activation of Wnt\/\u03b2-catenin pathway in the brain endothelium mitigates A\u03b2-induced blood-brain barrier dysfunction in Alzheimer\u2019s disease","volume":"19","author":"Yi","year":"2023","journal-title":"Alzheimer's Dementia"},{"issue":"4","key":"2026100711084763500_cit45","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103839","article-title":"Nanorepairers Rescue Inflammation-Induced Mitochondrial Dysfunction in Mesenchymal Stem Cells","volume":"9","author":"Zhai","year":"2021","journal-title":"Adv. Sci."},{"key":"2026100711084763500_cit46","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13123","article-title":"Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function","volume":"7","author":"Lee","year":"2016","journal-title":"Nat. Commun."},{"key":"2026100711084763500_cit47","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.biomaterials.2019.02.005","article-title":"Epac agonist improves barrier function in iPSC-derived endothelial colony forming cells for whole organ tissue engineering","volume":"200","author":"Yuan","year":"2019","journal-title":"Biomaterials"},{"issue":"4","key":"2026100711084763500_cit48","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70194","article-title":"Inhibition of hippocampal mossy fiber plasticity and episodic memory by human A\u03b2 oligomers is prevented by enhancing cAMP signaling in Alzheimer's mice","volume":"21","author":"Jin","year":"2025","journal-title":"Alzheimers Dement"},{"issue":"12","key":"2026100711084763500_cit49","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.tcb.2008.09.006","article-title":"Control of mitochondria dynamics and oxidative metabolism by cAMP, AKAPs and the proteasome","volume":"18","author":"Carlucci","year":"2008","journal-title":"Trends Cell Biol."},{"key":"2026100711084763500_cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2021.101390","article-title":"Bovine-derived MFG-E8 alleviating mitochondrial dysfunction via Akt\/Sirt1\/PGC-1\u03b1 and MAPK\/ERK signaling cascades","volume":"44","author":"Guan","year":"2021","journal-title":"Food Biosci."},{"issue":"14","key":"2026100711084763500_cit51","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.143540","article-title":"Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism","volume":"6","author":"Li","year":"2021","journal-title":"JCI Insight"},{"issue":"7","key":"2026100711084763500_cit52","doi-asserted-by":"publisher","first-page":"9074","DOI":"10.1007\/s12035-025-04807-7","article-title":"Targeted and Untargeted Proteomics-based Comparison of Adenoviral Infected hCMEC\/D3 and hBMEC as a Human Brain Endothelial Cells to Study the OATP2B1 Transporter","volume":"62","author":"Taggi","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"11","key":"2026100711084763500_cit53","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221137","article-title":"A \"multi-omics\" analysis of blood-brain barrier and synaptic dysfunction in APOE4 mice","volume":"219","author":"Barisano","year":"2022","journal-title":"J. Exp. Med."},{"issue":"7806","key":"2026100711084763500_cit54","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41586-020-2247-3","article-title":"APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline","volume":"581","author":"Montagne","year":"2020","journal-title":"Nature"},{"issue":"8","key":"2026100711084763500_cit55","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1161\/CIRCRESAHA.113.301207","article-title":"Carcinoembryonic antigen\u2212related cell adhesion molecule 1 inhibits MMP-9\u2212mediated blood\u2212brain\u2212barrier breakdown in a mouse model for ischemic stroke","volume":"113","author":"Ludewig","year":"2013","journal-title":"Circ. Res."},{"key":"2026100711084763500_cit56","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jconrel.2022.03.019","article-title":"Enhanced BBB and BBTB penetration and improved anti-glioma behavior of Bortezomib through dual-targeting nanostructured lipid carriers","volume":"345","author":"Masoud","year":"2022","journal-title":"J. Control. Release"},{"key":"2026100711084763500_cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2021.104976","article-title":"\u03b2-1, 3-galactosyltransferase 2 ameliorates focal ischemic cerebral injury by maintaining blood-brain barrier integrity","volume":"144","author":"Yang","year":"2021","journal-title":"Neurochem. Int."},{"issue":"S13","key":"2026100711084763500_cit58","doi-asserted-by":"publisher","DOI":"10.1002\/alz.075618","article-title":"The role of Alzheimer\u2019s risk factor ApoE4 on intracellular A\u03b2 aggregation","volume":"19","author":"Konings","year":"2023","journal-title":"Alzheimer's Dementia"},{"issue":"3","key":"2026100711084763500_cit59","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.cell.2016.12.044","article-title":"ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and A\u03b2 Secretion","volume":"168","author":"Huang","year":"2017","journal-title":"Cell"},{"issue":"S3","key":"2026100711084763500_cit60","doi-asserted-by":"publisher","DOI":"10.1002\/alz.043447","article-title":"Synapse disruption by Alzheimer\u2019s A\u03b2\/APP","volume":"16","author":"Gouras","year":"2020","journal-title":"Alzheimer's Dementia"},{"key":"2026100711084763500_cit61","doi-asserted-by":"publisher","first-page":"5777","DOI":"10.1038\/s41380-025-03217-4","article-title":"Hyperactivity of subicular parvalbumin interneurons drives early amyloid pathology and cognitive deficits in Alzheimer's disease","volume":"30","author":"Chen","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"2026100711084763500_cit62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2018.04.050","article-title":"Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: Sirt1\/miR-134 signalling pathway regulates CREB\/BDNF expression in hippocampus in vivo and in vitro","volume":"349","author":"Shen","year":"2018","journal-title":"Behav. Brain Res."},{"issue":"4","key":"2026100711084763500_cit63","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70103","article-title":"Structural changes in cerebral microvasculature induced by ferroptosis contribute to blood-brain barrier disruption in Alzheimer's disease: an autopsy study","volume":"21","author":"Cao","year":"2025","journal-title":"Alzheimers Dement."},{"issue":"2","key":"2026100711084763500_cit64","doi-asserted-by":"publisher","DOI":"10.1002\/exp2.70160","article-title":"RBFOX1 Dysfunction Unlocks APOE4-Associated Microglial Genesis and Exacerbates Alzheimer's Pathology in Human Cerebral Organoids","volume":"6","author":"Zhang","year":"2026","journal-title":"Exploration"},{"key":"2026100711084763500_cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102155","article-title":"Orally hierarchical targeting delivery systems relieve colitis by protecting host mitochondria and modulating gut microbiota","volume":"55","author":"Xing","year":"2024","journal-title":"Nano Today"},{"key":"2026100711084763500_cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.158774","article-title":"Preparation of NIR responsive resveratrol@Au nanocages using for regulating oxidative stress microenvironment of periodontitis","volume":"504","author":"Han","year":"2025","journal-title":"Chem. Eng. J."},{"key":"2026100711084763500_cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.137111","article-title":"F-53B disrupts energy metabolism by inhibiting the V-ATPase-AMPK axis in neuronal cells","volume":"487","author":"Zhang","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"22","key":"2026100711084763500_cit68","doi-asserted-by":"publisher","first-page":"22334","DOI":"10.1021\/acsnano.3c04462","article-title":"A Mitochondrial Nanoguard Modulates Redox Homeostasis and Bioenergy Metabolism in Diabetic Peripheral Neuropathy","volume":"17","author":"Yao","year":"2023","journal-title":"ACS Nano"},{"key":"2026100711084763500_cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107324","article-title":"The role of polyphenols in modulating mitophagy: Implications for therapeutic interventions","volume":"207","author":"Lin","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"2","key":"2026100711084763500_cit70","doi-asserted-by":"publisher","first-page":"100","DOI":"10.4103\/hm.HM-D-23-00075","article-title":"Cognitive Function in Atrial Fibrillation: A Narrative Review of Evidence and Mechanisms","volume":"8","author":"Agarwal","year":"2024","journal-title":"Heart Mind"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c10103","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/39\/53102\/68633866\/am-2026-10103w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/18\/39\/53102\/68633866\/am-2026-10103w.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:10:34Z","timestamp":1791389434000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/18\/39\/53102\/5437406\/Membrane-Coated-DNA-Nanoflowers-Attenuate"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":70,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2026,9,24]]},"published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.6c10103","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]}}}