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In this study, four surface modification strategies, femtosecond-pulsed laser treatment, oxygen plasma, polydopamine, and an ethyl-2-cyanoacrylate (ECA) interlayer, were evaluated for the integration of a dexamethasone (DEX)- and celecoxib (CLX)-releasing bilayer coating with a polycarbonate urethane (PCU) meniscus implant. The selected construct comprised an ECA interlayer applied from a 40% (w\/v) solution, a CLX-loaded PLLA\/PCL layer prepared at 100 mg\/mL and a 53\/47 (w\/w) polymer ratio with 16.6% CLX loading, and an outer DEX-loaded PLGA layer prepared at 200 mg\/mL with 2.44% DEX loading. At 37 \u00b0C, compared with uncoated PCU, ECA-containing constructs showed significantly higher storage modulus, loss modulus, and elastic modulus (p &amp;lt; 0.05), while tan \u03b4 remained unchanged, indicating preservation of the elastic-dominant viscoelastic response of the complete construct. The ECA-containing coating was subsequently adapted to the geometry of a sheep meniscus implant using an optimized dip-coating procedure. During a 21-day bioreactor study, repeated compression and shear increased cumulative DEX release from 59 to 67% and CLX release from 25 to 40% relative to static controls, while no visible coating delamination was observed. Ethylene oxide sterilization preserved drug loading and release behavior. In an exploratory three-month sheep study, the fiber-fixed coated implants remained in position, and the coating remained macroscopically associated with the retrieved prostheses. These findings support the use of an ECA interlayer to integrate a bilayer drug-releasing coating with a PCU meniscus implant while preserving construct-level mechanical behavior and drug release under the conditions evaluated.<\/jats:p>","DOI":"10.1021\/acsami.6c10220","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:02:26Z","timestamp":1791554546000},"page":"55815-55833","source":"Crossref","is-referenced-by-count":0,"title":["Polymer Coating Adhesion Drives Functional and Biological Outcomes in Meniscus Implants"],"prefix":"10.1021","volume":"18","author":[{"given":"Alfonso F.","family":"Blanco","sequence":"first","affiliation":[{"name":"University of Santiago de Compostela, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Health Research Institute of Santiago de Compostela (IDIS) , ,","place":["Santiago de Compostela, Spain, 15706"]},{"name":"Faculty of Pharmacy, University of Santiago de Compostela , , ,","place":["Santiago de Compostela, Spain, 15705"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Rubio-Prego","sequence":"additional","affiliation":[{"name":"University of Santiago de Compostela, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Health Research Institute of Santiago de Compostela (IDIS) , ,","place":["Santiago de Compostela, Spain, 15706"]},{"name":"Faculty of Pharmacy, University of Santiago de Compostela , , ,","place":["Santiago de Compostela, Spain, 15705"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0602-800X","authenticated-orcid":true,"given":"Carmen","family":"Bao-Varela","sequence":"additional","affiliation":[{"name":"University of Santiago de Compostela, Photonics4Life Group, Faculty of Physics and Faculty of Optics and Optometry, Materials Institute (iMATUS) , ,","place":["Santiago de Compostela, Spain, 15782"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Bouza","sequence":"additional","affiliation":[{"name":"University of A Coru\u00f1a, Industrial Campus, CITENI\u2013Polymers Group , ,","place":["Ferrol, Spain, 15403"]},{"name":"Cellular and Molecular Cardiology Research Unit, IDIS, Complexo Hospitalario Universitario de Santiago de Compostela, \u00c1rea Sanitaria Santiago de Compostela e Barbanza (SERGAS) , ,","place":["Santiago de Compostela, Spain, 15706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Nu\u00f1ez Bernal","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht , , ,","place":["Utrecht, The Netherlands, 3584 CX"]},{"name":"Regenerative Medicine Center Utrecht , ,","place":["Utrecht, The Netherlands, 3584 CT"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Levato","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht , , ,","place":["Utrecht, The Netherlands, 3584 CX"]},{"name":"Regenerative Medicine Center Utrecht , ,","place":["Utrecht, The Netherlands, 3584 CT"]},{"name":"Utrecht University , , ,","place":["Utrecht, The Netherlands, 3584 CL"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9241-7676","authenticated-orcid":true,"given":"Jos","family":"Malda","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht , , ,","place":["Utrecht, The Netherlands, 3584 CX"]},{"name":"Regenerative Medicine Center Utrecht , ,","place":["Utrecht, The Netherlands, 3584 CT"]},{"name":"Utrecht University , , ,","place":["Utrecht, The Netherlands, 3584 CL"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta","family":"Kon","sequence":"additional","affiliation":[{"name":"Humanitas University , , , ,","place":["Pieve Emanuele, Milan, Italy, 20072"]},{"name":"IRCCS Humanitas Research Hospital , , 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15706"]},{"name":"Faculty of Pharmacy, University of Santiago de Compostela , , ,","place":["Santiago de Compostela, Spain, 15705"]},{"name":"Madrid Institute for Advanced Studies in Nanoscience (IMDEA Nanoscience) , ,","place":["Madrid, Spain, 28049"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"issue":"30","key":"2026102609072671500_cit1","doi-asserted-by":"publisher","first-page":"7411","DOI":"10.1016\/J.BIOMATERIALS.2011.06.037","article-title":"The Knee Meniscus: Structure-Function, Pathophysiology, Current Repair Techniques, and Prospects for Regeneration","volume":"32","author":"Makris","year":"2011","journal-title":"Biomaterials"},{"key":"2026102609072671500_cit2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/B978-0-12-803581-8.09304-8","volume-title":"Comprehensive Biomaterials 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