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Matched HF and LF cultures were derived from a single glaucomatous donor eye (n = 3 gels per condition per region) and seeded on fibrillar type I collagen gels (elastic modulus 27.7 kPa) containing 0.2 \u03bcm FluoSpheres. Cells were imaged hourly for 12 h after latrunculin B (0.5 \u03bcM), no codazole (1 \u03bcM), or withaferin A (2 \u03bcM), with region-matched vehicle controls. In controls, reconstructed mean traction increased from 4 to 12 h in both HF (36.2\u201344.8 kPa) and LF (23.6\u201340.6 kPa). Latrunculin B reduced traction early with partial recovery, while nocodazole timepoint means differed between HF and LF at 12 h (HF: 64.1 kPa, 3.96% strain; LF: 17.3 kPa, 0.98% strain) and shifted divergence toward convergence. Withaferin A reduced traction, strain, and curl at 12 h in both HF and LF and differed from control in LF collagen orientation angle dynamics (p = 0.021). Mixed-effects models with Bonferroni correction did not detect treatment-control differences in the rate of change over time for traction, strain, divergence, or curl after accounting for HF\/LF; within LF, latrunculin B decreased divergence (p = 0.018) and withaferin A differed in strain change over time (p = 0.045). This segment-resolved assay supports comparative evaluation of cytoskeletal perturbations and motivates validation across additional donor-matched HF\/LF pairs.<\/jats:p>","DOI":"10.1021\/acsami.6c10225","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:29:46Z","timestamp":1783697386000},"page":"40443-40460","source":"Crossref","is-referenced-by-count":0,"title":["Differential Cytoskeletal Control of Cell-Collagen Mechanics in High- and Low-Flow Glaucomatous Trabecular Meshwork Cells"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0086-0367","authenticated-orcid":true,"given":"Alireza","family":"Karimi","sequence":"first","affiliation":[{"name":"Oregon Health & Science University , , , ,","place":["Portland, Oregon, United States, 97239"]},{"name":"Oregon Health & Science University , , , ,","place":["Portland, Oregon, United States, 97239"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasti","family":"Golchin","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University , , , ,","place":["Portland, Oregon, United States, 97239"]},{"name":"Oregon Health & Science University , , , ,","place":["Portland, Oregon, United States, 97239"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Adamec","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University , , , ,","place":["Portland, Oregon, United States, 97239"]},{"name":"Oregon Health & Science University , , , ,","place":["Portland, Oregon, United States, 97239"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansel","family":"Stanik","sequence":"additional","affiliation":[{"name":"Oregon State University , , , ,","place":["Corvallis, Oregon, United States, 97331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3335-3443","authenticated-orcid":true,"given":"Pretham","family":"Nandakumar","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University , , , ,","place":["Portland, Oregon, United States, 97239"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithran","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University , , , ,","place":["Portland, Oregon, United States, 97239"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mini","family":"Aga","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University , , , ,","place":["Portland, Oregon, United States, 97239"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"White","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University , , , ,","place":["Portland, Oregon, United States, 97239"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J","family":"Kelley","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University , , , ,","place":["Portland, Oregon, United States, 97239"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Acott","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University , , , ,","place":["Portland, Oregon, United States, 97239"]},{"name":"School of Medicine, Oregon Health & Science University , , , ,","place":["Portland, Oregon, United States, 97239"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"issue":"15","key":"2026080518091158400_cit1","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1056\/NEJM199304153281507","article-title":"Open-angle glaucoma","volume":"328","author":"Quigley","year":"1993","journal-title":"N. 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