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Here, we developed a thermosensitive injectable Sr2+-loaded OSA\u2013DTPH\u2013agarose hydrogel (Sr@OSDA) constructed through dynamic Schiff-base crosslinking, agarose-mediated physical networking, and reversible Sr2+\u2013carboxylate coordination interactions. The hydrogel exhibited favorable biocompatibility, mechanical properties comparable to native myocardium, and sustained local Sr2+ availability within the infarct microenvironment. Unlike conventional multicomponent strategies, Sr@OSDA employed Sr2+ as the primary bioactive cue while maintaining a simplified therapeutic design. In a rat MI model, Sr@OSDA significantly promoted angiogenesis, which was associated with the activation of the AKT\/eNOS signaling pathway and enhanced CD31+ microvessel density and \u03b1-SMA+ arteriole formation. Moreover, Sr@OSDA enhanced reparative macrophage responses, modulated autophagic activity during the early stage after MI, and partially restored connexin 43 (Cx43) expression. These coordinated reparative responses contributed to improved myocardial repair and attenuated adverse ventricular remodeling after infarction. Collectively, Sr@OSDA provides a mechanically adaptive hydrogel platform with bioactive ion delivery capability for ischemic myocardial repair by harnessing the pleiotropic bioactivities of Sr2+.<\/jats:p>","DOI":"10.1021\/acsami.6c10597","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:17:58Z","timestamp":1785849478000},"page":"42386-42403","source":"Crossref","is-referenced-by-count":0,"title":["A Sr2+-Incorporated Polysaccharide Hydrogel Promotes Multifunctional Cardiac Repair after Myocardial Infarction"],"prefix":"10.1021","volume":"18","author":[{"given":"Xiaoyu","family":"Bai","sequence":"first","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Lei","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University , ,","place":["Lanzhou, China, 730000"]},{"name":"the First Hospital of Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiang","family":"Shi","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University , ,","place":["Lanzhou, China, 730000"]},{"name":"Department of General Surgery, Xijing 986th Hospital, Fourth Military Medical University , ,","place":["Xi'an, China, 710000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyu","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Hu","sequence":"additional","affiliation":[{"name":"the First Hospital of Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Jiang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeao","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Xijing Hospital, Fourth Military Medical University , , ,","place":["Xi'an, China, 710032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2325-093X","authenticated-orcid":true,"given":"Quan","family":"Qi","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University , ,","place":["Lanzhou, China, 730000"]},{"name":"the First Hospital of Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"2026081706073333800_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.114414","article-title":"Recent Advances in Biomimetic Nanodelivery Systems for the Treatment of Myocardial Ischemia Reperfusion Injury","volume":"247","author":"Bi","year":"2025","journal-title":"Colloids Surf., B"},{"issue":"2","key":"2026081706073333800_cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-020-0775-5","article-title":"TRPV4 Deletion Protects Heart from Myocardial Infarction-Induced Adverse Remodeling via Modulation of Cardiac Fibroblast Differentiation","volume":"115","author":"Adapala","year":"2020","journal-title":"Basic Res. 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