{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:04:24Z","timestamp":1786118664022,"version":"build-2736575974"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1515230010"],"award-info":[{"award-number":["2023B1515230010"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pelvic organ prolapse is a prevalent condition that impairs the quality of life in middle-aged and elderly women. Traditional polypropylene (PP) surgical meshes often lead to long-term complications due to mechanical mismatch and biological inertness, manifesting as stress concentration and chronic inflammation. To concurrently address these dual challenges, this study designed and fabricated a multifunctional composite mesh. The mesh incorporates a clinical-grade PP base for mechanical support, integrated with a three-dimensional printed polycaprolactone (PCL) biomimetic network modified by quaternized chitosan (QCS). Human umbilical cord mesenchymal stem cell-derived exosomes (Exos) were further loaded onto this network via electrostatic adsorption. The PP\/PCL\/QCS composite mesh demonstrated structural integrity and stable degradation. Finite element analysis verified its unique stress-buffering and redistribution capability, which effectively mitigates interfacial stress concentration. Biologically, the PP\/PCL\/QCS\/Exos mesh promoted cell proliferation and adhesion in vitro and showed good biocompatibility in vivo. It actively modulated the repair microenvironment, leading to a rapidly resolved inflammatory response, reduced macrophage infiltration, enhanced myofibroblast activation, and orderly collagen remodeling with a significant increase in collagen type III. Transcriptomic analysis revealed that the mesh induces a systemic anti-inflammatory and pro-repair molecular phenotype. In summary, this work achieves a strategic shift from passive support to active regeneration through synergistic mechanical and biological design, offering a promising direction toward next-generation pelvic floor repair.<\/jats:p>","DOI":"10.1021\/acsami.6c10635","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:12:52Z","timestamp":1784823172000},"page":"40490-40504","source":"Crossref","is-referenced-by-count":0,"title":["Exosome-Laden 3D Composite Mesh Attenuates Stress Concentration and Promotes Collagen Regeneration toward Pelvic Organ Prolapse Repair"],"prefix":"10.1021","volume":"18","author":[{"given":"Junyi","family":"Duan","sequence":"first","affiliation":[{"name":"Zhuhai People's Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University) , , ,","place":["Zhuhai, China, 519000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhuhai People's Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University) , , ,","place":["Zhuhai, China, 519000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zuo","sequence":"additional","affiliation":[{"name":"Zhuhai People's Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University) , , ,","place":["Zhuhai, China, 519000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang Shangyue Biotechnology Co., Ltd. , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunye","family":"Zhang","sequence":"additional","affiliation":[{"name":"National University of Singapore (Suzhou) Research Institute , , ,","place":["Suzhou, China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4787-9691","authenticated-orcid":true,"given":"Wenjun","family":"Wang","sequence":"additional","affiliation":[{"name":"National University of Singapore (Suzhou) Research Institute , , ,","place":["Suzhou, China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mubiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhuhai People's Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University) , , ,","place":["Zhuhai, China, 519000"]},{"name":"Zhuhai Center for Maternal and Child Health Care , , Medical Education Center of Jinan University, ,","place":["Zhuhai, China, 519000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"2026080612062330200_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123861","article-title":"Macrophage-to-myofibroblast transition (MMT) - 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