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Here, we present a smartphone-guided, artificial-intelligence-enhanced LFIA platform that unites a rationally engineered dual-modal nanoprobe with on-device machine learning, demonstrated for quantitative detection of Rift Valley fever virus (RVFV). The platform combines three synergistic principles: advanced magnetic quantum dot nanoparticles (AQDs) that integrate a magnetic core and a quantum dot shell in a single label to provide both colorimetric and fluorescence signals while enabling magnetic preconcentration of the target antigen; multi-illumination imaging that turns an ordinary smartphone camera into a quantitative reader; and a machine-learning model that extracts illumination-robust features to convert signal into concentration, removing user subjectivity and lighting sensitivity. This design markedly improves sensitivity over conventional gold-nanosphere LFIA in both modes, enables reliable quantification directly in serum without any pretreatment, and outperforms naked-eye interpretation in blind testing. By coupling dual-modal amplification and magnetic enrichment with AI-driven analysis on widely available hardware, the AQD-LFIA platform offers a scalable route toward next-generation point-of-care and at-home diagnostics.<\/jats:p>","DOI":"10.1021\/acsami.6c10769","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:03:57Z","timestamp":1789779837000},"page":"52891-52907","source":"Crossref","is-referenced-by-count":0,"title":["Smartphone AI-Enabled Lateral Flow Immunoassay Platform Using Advanced Quantum Dots for Intelligent Quantitative Diagnostics"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5489-268X","authenticated-orcid":true,"given":"Supriya","family":"Atta","sequence":"first","affiliation":[{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]},{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5887-3633","authenticated-orcid":true,"given":"Taylor L.","family":"Thorsen","sequence":"additional","affiliation":[{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]},{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Vasse","sequence":"additional","affiliation":[{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]},{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa K.","family":"Berner","sequence":"additional","affiliation":[{"name":"University of Nevada, Reno School of Medicine , , , ,","place":["Reno, Nevada, United States, 89557"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcellene A.","family":"Gates-Hollingsworth","sequence":"additional","affiliation":[{"name":"University of Nevada, Reno School of Medicine , , , ,","place":["Reno, Nevada, United States, 89557"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haydon J.","family":"Hill","sequence":"additional","affiliation":[{"name":"University of Nevada, Reno School of Medicine , , , ,","place":["Reno, Nevada, United States, 89557"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"AuCoin","sequence":"additional","affiliation":[{"name":"University of Nevada, Reno School of Medicine , , , ,","place":["Reno, Nevada, United States, 89557"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5924-856X","authenticated-orcid":true,"given":"Xiaoshan","family":"Zhu","sequence":"additional","affiliation":[{"name":"University of Nevada, Reno , , , ,","place":["Reno, Nevada, United States, 89557"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3701-3326","authenticated-orcid":true,"given":"Tuan","family":"Vo-Dinh","sequence":"additional","affiliation":[{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]},{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]},{"name":"Duke University , , , ,","place":["Durham, North Carolina, United States, 27708"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"issue":"2","key":"2026093002075850200_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15020123","article-title":"Impact of Point-of-Care Testing on Diagnosis, Treatment, and Surveillance of Vaccine-Preventable Viral Infections","volume":"15","author":"Lakshmanan","year":"2025","journal-title":"Diagnostics"},{"issue":"4, Suppl.","key":"2026093002075850200_cit2","doi-asserted-by":"publisher","first-page":"S163","DOI":"10.1016\/j.ijtb.2020.07.034","article-title":"Benefits and limitations of serological assays in COVID-19 infection","volume":"67","author":"Sidiq","year":"2020","journal-title":"Indian J. 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