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Herein, we report a modular polyacrylamide-co-acrylic acid N-hydroxysuccinimide (PAM-AA-NHS) hydrogel platform offering chemical versatility and mechanical tunability for precision care. To impart specific bio functionalities, adhesive-active functional materials, including tannic acid (TA), oxidized dextran (ODex), and catechol-conjugated chitosan (CHI-C), were individually incorporated into the hydrogel. TA-modified hydrogel demonstrated exceptional freeze-tolerant adhesion, retaining over 50% of its original adhesive strength at \u201320 \u00b0C and enabling effective wound healing under low-temperature conditions. ODex functionalization exhibited potent antibacterial activity (&amp;gt;95% inhibition), suggesting its potential for the management of infection-prone wounds. Furthermore, CHI-C-integrated hydrogel showed enhanced mechanical strength (tensile: 55.64 \u00b1 3.71 kPa; compressive: 525.07 \u00b1 13.80 kPa) and promoted erythrocyte aggregation via electrostatic interactions, achieving effective hemostasis under high-pressure bleeding conditions with blood loss reduced to 41.67 \u00b1 4.11 mg in liver and 70.33 \u00b1 6.60 mg in cardiac injury models. All hydrogel variants displayed favorable hemocompatibility, cytocompatibility, and significant in vivo wound healing performance. Collectively, this study presents a modular hydrogel system with tailored functional characteristics for diverse wound-management requirements, including low-temperature protection, antibacterial protection, and hemorrhage control.<\/jats:p>","DOI":"10.1021\/acsami.6c11002","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:02:02Z","timestamp":1789581722000},"page":"52034-52054","source":"Crossref","is-referenced-by-count":0,"title":["Modular Engineered Hydrogels with Tailored Adhesive, Antibacterial, and Hemostatic Functions for Diverse Wound Healing Applications"],"prefix":"10.1021","volume":"18","author":[{"given":"Gaoxing","family":"Pan","sequence":"first","affiliation":[{"name":"Fuzhou University , , 2 Xueyuan Road , ,","place":["Fuzhou, P. R. 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