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Polyglycerol (PG) grafting improves colloidal stability and suppresses nonspecific biomolecular adsorption; however, it can also reduce intestinal retention, making sufficient ND loading a key challenge for in vivo optically detected magnetic resonance (ODMR) imaging. Here, we introduce PG-grafted NDs with different terminal groups, \u2013COOH, OSO3Na, and NH2, to investigate charge-dependent biocompatibility for whole-intestinal ODMR imaging in Caenorhabditis elegans (C. elegans). Positively charged ND-PG-NH2 exhibits the highest intestinal retention in C. elegans without detectable toxicity while maintaining bright fluorescence and stable NV spin signals. Combined with an adaptive masking algorithm to remove halo artifacts resulting from strong fluorescence, this labeling strategy enables reliable two-dimensional in vivo spin-active fluorescence imaging over the entire worm body. These findings identify surface-charge engineering of ND-PG-NH2 as a practical strategy for establishing bright and biocompatible workflows for quantum-sensor-based bioimaging.<\/jats:p>","DOI":"10.1021\/acsami.6c11158","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:08:06Z","timestamp":1792087686000},"page":"58490-58503","source":"Crossref","is-referenced-by-count":0,"title":["Charge-Engineered Polyglycerol Nanodiamonds for Enhanced Intestinal Retention and NV Spin Imaging in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1021","volume":"18","author":[{"given":"Kazuki","family":"Kinjo","sequence":"first","affiliation":[{"name":"Okayama University , , ,","place":["Okayama, Japan, 700-8530"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiya","family":"Kamada","sequence":"additional","affiliation":[{"name":"Okayama University , , ,","place":["Okayama, Japan, 700-8530"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Taki","sequence":"additional","affiliation":[{"name":"Okayama University , , ,","place":["Okayama, Japan, 700-8530"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahono","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Okayama University , , ,","place":["Okayama, Japan, 700-8530"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4531-5194","authenticated-orcid":true,"given":"Sara","family":"Mandic\u0301","sequence":"additional","affiliation":[{"name":"Okayama University , , ,","place":["Okayama, Japan, 700-8530"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaki","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Okayama University , , ,","place":["Okayama, Japan, 700-8530"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Ikado","sequence":"additional","affiliation":[{"name":"Okayama University , , ,","place":["Okayama, Japan, 700-8530"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Oshimi","sequence":"additional","affiliation":[{"name":"Okayama University , , ,","place":["Okayama, Japan, 700-8530"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simo","family":"Sun","sequence":"additional","affiliation":[{"name":"Chinese Institute for Brain Research, Beijing (CIBR) , Bldg.3, NO.9, YIKE Rd, Zhongguancun Life Science Park, Changping District , ,","place":["Beijing, China, 102206"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5068-0460","authenticated-orcid":true,"given":"Eriko","family":"Kage-Nakadai","sequence":"additional","affiliation":[{"name":"Kyoto University , , Sakyo-ku , ,","place":["Kyoto, Japan, 606-8507"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3249-7173","authenticated-orcid":true,"given":"Naoki","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Kyoto University , , Sakyo-ku , ,","place":["Kyoto, Japan, 606-8501"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Patton","sequence":"additional","affiliation":[{"name":"University of Strathclyde , , ,","place":["Glasgow, U.K., G4 0NG"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7845-2387","authenticated-orcid":true,"given":"Masazumi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Okayama University , , ,","place":["Okayama, Japan, 700-8530"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"2026102805082316200_cit1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1146\/annurev-physchem-040513-103659","article-title":"Nitrogen-Vacancy Centers in Diamond: Nanoscale Sensors for Physics and Biology","volume":"65","author":"Schirhagl","year":"2014","journal-title":"Annu. Rev. Phys. Chem."},{"key":"2026102805082316200_cit2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba9636","article-title":"Real-time nanodiamond thermometry probing in vivo thermogenic responses","volume":"6","author":"Fujiwara","year":"2020","journal-title":"Sci. Adv."},{"key":"2026102805082316200_cit3","doi-asserted-by":"publisher","DOI":"10.1088\/2399-1984\/ad9975","article-title":"Emerging trends in fluorescent nanodiamond quantum sensing","volume":"8","author":"Hui","year":"2024","journal-title":"Nano Futures"},{"key":"2026102805082316200_cit4","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202200059","article-title":"Recent Developments of Nanodiamond Quantum Sensors for Biological Applications","volume":"9","author":"Wu","year":"2022","journal-title":"Adv. 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