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Herein, a folic acid (FA)-functionalized nanoplatform (FA-LP-ICG\/DOX) was designed and fabricated for combined chemophotothermal therapy of cervical cancer. Anticancer drug doxorubicin (DOX) and photothermal agent indocyanine green (ICG) are co-loaded in the core of the liposome, followed by the modification of folic acid as the targeting ligand on the outer surface. Under near-infrared (NIR) laser irradiation, FA-LP-ICG\/DOX can convert NIR energy into hyperthermia, demonstrating outstanding photothermal conversion efficiency. Experimental results indicate that FA-LP-ICG\/DOX exhibits enhanced cellular internalization, good biocompatibility, and significant tumor-suppressive effects under NIR laser irradiation, which offers a promising strategy for treating cervical cancer through combined chemophotothermal therapy.<\/jats:p>","DOI":"10.1021\/acsami.6c11448","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:02:08Z","timestamp":1791914528000},"page":"57030-57042","source":"Crossref","is-referenced-by-count":0,"title":["Folic Acid-Functionalized Liposomes Co-Loaded with Doxorubicin and Indocyanine Green for Combined Chemophotothermal Therapy of Cervical Cancer"],"prefix":"10.1021","volume":"18","author":[{"given":"Huijia","family":"Lei","sequence":"first","affiliation":[{"name":"Jilin University , , 2699 Qianjin Street , ,","place":["Changchun, P. R. 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