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However, a therapeutic strategy that simultaneously addresses these interconnected pathologies remains elusive in current nanomedicine. In this study, we prepare a DNA nanostructure with antioxidant enzyme-mimetic activities through the coordination-driven co-assembly of oligonucleotides and inorganic cerium pyrophosphate crystals. After intra-articular injection, the valence transition property of cerium ions enables the nanoparticles to scavenge reactive oxygen species, thereby ameliorating oxidative stress-induced articular cartilage damage and facilitating cartilage extracellular matrix regeneration. Meanwhile, the adenosine-rich oligonucleotide induces M2 macrophage polarization, thereby alleviating inflammatory responses. Notably, the presence of pyrophosphate anions directly inhibits osteoclast activity, facilitating subchondral bone remodeling. This work demonstrates a universal coordination-driven strategy, which can be adopted to prepare other enzyme-mimetic nanoparticles through tailoring the components and structures for the targeted treatment of diseases beyond OA.<\/jats:p>","DOI":"10.1021\/acsami.6c11655","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:02:21Z","timestamp":1790708541000},"page":"54456-54472","source":"Crossref","is-referenced-by-count":0,"title":["Coordination of Oligonucleotides into Enzyme-Mimetic Nanostructures for Ameliorating Osteoarthritis through Intervening in Articular Cartilage and Subchondral Bone"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3478-4614","authenticated-orcid":true,"given":"Xuan","family":"Yang","sequence":"first","affiliation":[{"name":"Tongji University , , 4800 Caoan Road , ,","place":["Shanghai, China, 201804"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4262-5250","authenticated-orcid":true,"given":"Jianhua","family":"Li","sequence":"additional","affiliation":[{"name":"Tongji University , , 4800 Caoan Road , ,","place":["Shanghai, China, 201804"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3135-3242","authenticated-orcid":true,"given":"Jingjing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Tongji University , , 4800 Caoan Road , ,","place":["Shanghai, China, 201804"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dantong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Tongji University , , 4800 Caoan Road , ,","place":["Shanghai, China, 201804"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-6093","authenticated-orcid":true,"given":"Yong","family":"Hu","sequence":"additional","affiliation":[{"name":"Tongji University , , 4800 Caoan Road , ,","place":["Shanghai, China, 201804"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-5669","authenticated-orcid":true,"given":"Jianzhong","family":"Du","sequence":"additional","affiliation":[{"name":"Tongji University , , 4800 Caoan Road , ,","place":["Shanghai, China, 201804"]},{"name":"School of Materials Science and Engineering, East China University of Science and Technology , ,","place":["Shanghai, China, 200237"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"2026101404070294000_cit1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/s41584-020-00518-6","article-title":"Emerging Pharmaceutical Therapies for Osteoarthritis","volume":"16","author":"Latourte","year":"2020","journal-title":"Nat. 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