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Here, we report a machine-learning-enhanced three-channel colorimetric sensor array based on Cu-Pt bimetallic nanozymes for multi-class pesticide fingerprint recognition. The single CuPtBN receptor integrates oxidase-, laccase-, and superoxide dismutase-like activities, generating three orthogonal optical response channels that capture differential inhibition and promotion effects from structurally similar pesticides. By coupling these multidimensional signals with \u201cclassification-regression\u201d dual-loop machine learning models, the platform achieves concentration-independent qualitative identification and precise quantitative prediction, with 100% classification accuracy for nine representative pesticides and reliable predictive capability for nonlinear-response analytes. In blind tests and real agricultural samples, the system accurately identified pesticide species with prediction errors below 5% and recoveries of 85\u2212105%. This work establishes a simplified yet information-rich multichannel nanozyme sensing strategy, highlighting its promise for high-throughput food safety screening and intelligent agrochemical monitoring.<\/jats:p>","DOI":"10.1021\/acsami.6c11910","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:01:38Z","timestamp":1786122098000},"page":"44080-44092","source":"Crossref","is-referenced-by-count":0,"title":["Machine Learning-Enhanced Three-Channel Cu-Pt Bimetallic Nanozyme Sensor Array for Multi-Class Pesticide Fingerprint Discrimination"],"prefix":"10.1021","volume":"18","author":[{"given":"Mingze","family":"Sun","sequence":"first","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lou","sequence":"additional","affiliation":[{"name":"The Second Hospital of Jilin University , , No. 218 Ziqiang Street, Changchun , ,","place":["Jilin Province, China, 130041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhao","family":"Yin","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxin","family":"Liang","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Song","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Niu","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiezhu","family":"Li","sequence":"additional","affiliation":[{"name":"Jilin Academy of Agricultural Sciences , , ,","place":["Changchun, China, 130033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2655-535X","authenticated-orcid":true,"given":"Yibing","family":"Huang","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3231-2039","authenticated-orcid":true,"given":"Quan","family":"Luo","sequence":"additional","affiliation":[{"name":"Jilin University , , ,","place":["Changchun, China, 130012"]},{"name":"Jilin University , , ,","place":["Changchun, China, 130012"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"issue":"9612","key":"2026081905143091200_cit1","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S0140-6736(07)61202-1","article-title":"Management of acute organophosphorus pesticide poisoning","volume":"371","author":"Eddleston","year":"2008","journal-title":"Lancet"},{"issue":"5","key":"2026081905143091200_cit2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096580","article-title":"Quantifying synergy: a systematic review of mixture toxicity studies within environmental toxicology","volume":"9","author":"Cedergreen","year":"2014","journal-title":"PLoS One"},{"key":"2026081905143091200_cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.138942","article-title":"Prioritization of currently used pesticides in soils of main European cropping systems and an Argentinian cropping system for assessment of mixture toxicity and risk on terrestrial biota","volume":"495","author":"Jegede","year":"2025","journal-title":"J. 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