{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:03:49Z","timestamp":1786118629165,"version":"build-2736575974"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"SEU Innovation Capability Enhancement Plan for Doctoral Students","award":["CXJH_SEU 24220"],"award-info":[{"award-number":["CXJH_SEU 24220"]}]},{"name":"Lianyungang City 521 Talent Project","award":["LYG065212024081"],"award-info":[{"award-number":["LYG065212024081"]}]},{"name":"Lianyungang Municipal Science and Technology Bureau\u2019s Key Research and Development Project \u2013 Social Development","award":["SF2209"],"award-info":[{"award-number":["SF2209"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pancreatic ductal adenocarcinoma (PDAC), a refractory cold tumor, is characterized by a dense extracellular matrix (ECM) and stress-triggered neuroimmune crosstalk, which cause T cell exhaustion and poor efficacy of anti-T cell immunoglobulin and mucin domain-3 antibody (aTIM-3) monotherapy. Here, we report a sucrose-hybridized, Pan02 pancreatic tumor cell membrane-coated ultrasound (US)-responsive biomimetic nanocarrier (CT@SM) co-loading carvedilol (\u03b2-blocker) and aTIM-3. The Pan02 tumor cell membrane shell enables homologous tumor targeting, prolonged circulation, and reduced off-target distribution, while intercalated sucrose modulates vesicle acoustic impedance to generate US-triggered inertial cavitation. US activates cavitation to disrupt the ECM and co-releases cargos deep in tumors: carvedilol relieves norepinephrine-mediated T cell exhaustion, and aTIM-3 suppresses M2-type tumor-associated macrophages. Consequently, compared to free aTIM-3, up to an 11.23-fold increase of aTIM-3 in the tumor region was obtained in the CT@SM + US group. Immunotherapy efficacy was significantly enhanced by reactivating T cells, leading to suppressed tumor growth and prolonged survival in the PDAC mice stress model. Overall, this study offers a promising strategy based on a dual-modified biomimetic acoustic delivery platform for immunotherapy in PDAC and other cold tumors.<\/jats:p>","DOI":"10.1021\/acsami.6c11946","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T17:28:04Z","timestamp":1784654884000},"page":"40576-40595","source":"Crossref","is-referenced-by-count":0,"title":["Enhancing Pancreatic Ductal Adenocarcinoma Immunotherapy under Stress through Sympathetic Nerve\u2013T cell Interaction Blockade via Co-delivery of \u03b2-Blockers and aTIM-3 with Ultrasound-Responsive Bionic Nanoparticles"],"prefix":"10.1021","volume":"18","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang Medical-Education Innovation and Research Center, Nanjing Medical University , , ,","place":["Lianyungang, China, 222002"]},{"name":"Lianyungang Clinical College of Nanjing Medical University, The First People's Hospital of Lianyungang , ,","place":["Lianyungang, China, 222002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longdi","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People's Hospital of Lianyungang , , ,","place":["Lianyungang, China, 222002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People's Hospital of Lianyungang , , ,","place":["Lianyungang, China, 222002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengcheng","family":"Yun","sequence":"additional","affiliation":[{"name":"Zhongda Hospital, Medical School, Southeast University , , 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222002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Feng","sequence":"additional","affiliation":[{"name":"The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang Medical-Education Innovation and Research Center, Nanjing Medical University , , ,","place":["Lianyungang, China, 222002"]},{"name":"Lianyungang Clinical College of Nanjing Medical University, The First People's Hospital of Lianyungang , ,","place":["Lianyungang, China, 222002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Miao","sequence":"additional","affiliation":[{"name":"The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People's Hospital of Lianyungang , , ,","place":["Lianyungang, China, 222002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjiu","family":"Dai","sequence":"additional","affiliation":[{"name":"The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang Medical-Education Innovation and Research Center, Nanjing Medical University , , ,","place":["Lianyungang, China, 222002"]},{"name":"Lianyungang Clinical College of Nanjing Medical University, The First People's Hospital of Lianyungang , ,","place":["Lianyungang, China, 222002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang Medical-Education Innovation and Research Center, Nanjing Medical University , , ,","place":["Lianyungang, China, 222002"]},{"name":"Lianyungang Clinical College of Nanjing Medical University, The First People's Hospital of Lianyungang , ,","place":["Lianyungang, China, 222002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang Medical-Education Innovation and Research Center, Nanjing Medical University , , ,","place":["Lianyungang, China, 222002"]},{"name":"Lianyungang Clinical College of Nanjing Medical University, The First People's Hospital of Lianyungang , ,","place":["Lianyungang, China, 222002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8869-1746","authenticated-orcid":true,"given":"Lei","family":"Dong","sequence":"additional","affiliation":[{"name":"Zhongda Hospital, Medical School, Southeast University 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