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Conventional radionuclide (e.g., 90Sr, 32P) patches for beta-ray external beam radiotherapy suffer from rigid structures, leading to off-target irradiation, uneven radionuclide distribution, inconsistent dosing, and potential leakage risks. To address these limitations, we developed an innovative, flexible radioactive patch (32P-RU) by integrating 32P-loaded resin microspheres with boric acid-modified flexible polydimethylsiloxane (PBDMS) gel (P4U), enabling robust adsorption of H32PO42-, homogeneous distribution, and precise, repeated reshaping to conform to irregular lesions. As a pure beta emitter, 32P (Emax = 1.71 MeV, T1\/2 = 14.28 d, tissue penetration depth = 4 mm) minimizes damage to adjacent normal tissues. In preclinical models, 32P-RU demonstrated significant therapeutic efficacy: in rabbit ear hypertrophic scar models, five 4 Gy fractions reduced scar volume and improved collagen organization; in murine subcutaneous melanoma models, five 8 Gy fractions effectively suppressed tumor growth. Notably, combining 32P-RU with the immune checkpoint inhibitor (anti-PD-L1) synergistically enhanced anti-tumor effect, promoting dendritic cell maturation, increasing CD8+ T cell infiltration, and suppressing both primary and distant tumors. This conformal, safe, and effective 32P-RU patch offers a strategy for the precise treatment of superficial skin diseases, including refractory cutaneous malignancies.<\/jats:p>","DOI":"10.1021\/acsami.6c12098","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T07:44:36Z","timestamp":1785138276000},"page":"41858-41868","source":"Crossref","is-referenced-by-count":0,"title":["Flexible Radioactive Patch: Reshaping the Paradigm for Scar and Cutaneous Tumor Treatment"],"prefix":"10.1021","volume":"18","author":[{"given":"Qian","family":"Huang","sequence":"first","affiliation":[{"name":"Soochow University , , ,","place":["Suzhou, China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Soochow University , , ,","place":["Suzhou, China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Soochow University , , ,","place":["Suzhou, China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Qin","sequence":"additional","affiliation":[{"name":"Soochow University , , ,","place":["Suzhou, China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunhao","family":"Qi","sequence":"additional","affiliation":[{"name":"Soochow University , , ,","place":["Suzhou, China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"Soochow University , , ,","place":["Suzhou, China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Soochow University , , ,","place":["Suzhou, China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taole","family":"Liu","sequence":"additional","affiliation":[{"name":"Soochow University , , , ,","place":["Suzhou, Jiangsu, China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6784-3182","authenticated-orcid":true,"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Anhui Agricultural University , , ,","place":["Hefei, People's Republic of China, 230036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Pei","sequence":"additional","affiliation":[{"name":"Soochow University , , ,","place":["Suzhou, China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9351-4702","authenticated-orcid":true,"given":"Ran","family":"Zhu","sequence":"additional","affiliation":[{"name":"Soochow University , , ,","place":["Suzhou, China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6463-119X","authenticated-orcid":true,"given":"Guanglin","family":"Wang","sequence":"additional","affiliation":[{"name":"Soochow University , , ,","place":["Suzhou, China, 215123"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"2026080612073927900_cit1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.jiec.2025.07.013","article-title":"Radiation-Resistant and Biocompatible Hydrogels for Noninvasive Skin Health Monitoring and Wound Healing","volume":"154","author":"Yan","year":"2025","journal-title":"J. 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