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A strategic protein engineering approach, utilizing carbon-specific solid-binding peptides (SBPs), enabled oriented enzyme assembly to facilitate efficient interfacial electron transfer. Among the variants, the dual-functionalized system\u2014comprising C-terminal SBP-fused CR and N-terminal ferredoxin (Fd)\/SBP-fused DP3\u2014exhibited superior bioelectrocatalytic synergy, achieving a current density of \u2013193.35 \u00b5A cm\u20132. At \u20130.5 V (vs Ag\/AgCl), this integrated interface effectively drove the endergonic reduction process, maintaining continuous cofactor regeneration with an electron transfer efficiency of 39.2%.<\/jats:p>","DOI":"10.1021\/acsami.6c12368","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:01:39Z","timestamp":1791824499000},"page":"56070-56080","source":"Crossref","is-referenced-by-count":0,"title":["Interfacial Cofactor Recycling Electroenzymatic Platform for Endergonic CO2 Reduction"],"prefix":"10.1021","volume":"18","author":[{"given":"J. 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