{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:54:55Z","timestamp":1791388495289,"version":"4.3.3"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Shanxi Veterinary Pharmaceutical Industry Technology Innovation Strategic Alliance","award":["2025CXYRH-046"],"award-info":[{"award-number":["2025CXYRH-046"]}]},{"name":"Shanxi Key Laboratory of Animal Disease Research, Prevention and Control","award":["202504010931010"],"award-info":[{"award-number":["202504010931010"]}]},{"name":"?SanJin? Talents Program for Cultivating Scientific and Technological Innovation Talents","award":["CGPY2024001"],"award-info":[{"award-number":["CGPY2024001"]}]},{"name":"Shanxi Veterinary Pharmaceutical Industry Technology Innovation Research Institute (Industrial College) (1331 Project)","award":["2025CXYRH-042"],"award-info":[{"award-number":["2025CXYRH-042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Porcine epidemic diarrhea virus (PEDV) remains a major threat to the global swine industry, with current inactivated vaccines offering limited cross-protection due to imperfect antigen design and weak immune activation. Here, we engineered a full-structural-protein virus-like particle (VLP) co-assembled with PEDV S, M, N, and E proteins into uniform nanoscale particles, further formulated with a dual-adjuvant system of AS03 and CpG ODN. The VLP + AS03 + CpG nanovaccine elicited 10\u201312-fold higher PEDV-specific IgG than unadjuvanted VLPs, outperformed a commercial inactivated vaccine in mice, and induced a balanced Th1\/Th2 response with elevated IL-4, IFN-\u03b3, IL-10, and IL-17A. In piglets, the nanovaccine conferred robust protection against PEDV challenge, reducing jejunal viral load by 79% and preserving intestinal mucosal barrier integrity. This work presents a promising PEDV vaccine candidate and a broadly applicable strategy for coronavirus VLP vaccine design.<\/jats:p>","DOI":"10.1021\/acsami.6c12664","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:01:44Z","timestamp":1790103704000},"page":"53197-53213","source":"Crossref","is-referenced-by-count":0,"title":["Self-Assembled PEDV Virus-Like Particle Nanovaccines Elicit Potent Neutralizing Antibodies and Confer Full Protection in Piglets"],"prefix":"10.1021","volume":"18","author":[{"given":"Feiyang","family":"Jiang","sequence":"first","affiliation":[{"name":"Shanxi Agricultural University , , No. 1 Mingxian South Road , , ,","place":["Taigu, Shanxi, P.R. China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianmei","family":"Bai","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , No. 1 Mingxian South Road , , ,","place":["Taigu, Shanxi, P.R. China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , No. 1 Mingxian South Road , , ,","place":["Taigu, Shanxi, P.R. China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidi","family":"Song","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , No. 1 Mingxian South Road , , ,","place":["Taigu, Shanxi, P.R. China, 030801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeeshan","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Shanxi Agricultural University , , No. 1 Mingxian South Road , , ,","place":["Taigu, Shanxi, P.R. 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