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However, existing studies have revealed that the isolated clearance of amyloid-beta (A\u03b2), reactive oxygen species (ROS), or neuroinflammation confers no significant benefit on cognitive and memory function in AD patients. Thus, given the complex pathogenic mechanisms underlying AD, multitarget synergistic therapy represents a promising therapeutic strategy. Herein, we reported coordination polymer nanoparticles, Ce-Ru@Trf NPs, composed of cerium (Ce), rutin (Ru), and transferrin (Trf), which efficiently scavenge various ROS and anti-neuroinflammation and inhibit A\u03b2 fibrillization. Owing to Trf modification, its accumulation in brain tissues increased significantly. The Ce-Ru@Trf NPs also dampened neuroinflammation by redirecting microglia toward the M2 phenotype and curtailing proinflammatory factor release. In an AD APP\/PS1 model, it significantly achieved a neuroprotective effect and improved cognitive function. The findings suggest that biocompatible coordination polymers composed of metals and natural products may offer a viable therapeutic strategy for Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1021\/acsami.6c12785","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:20:35Z","timestamp":1788409235000},"page":"48855-48871","source":"Crossref","is-referenced-by-count":0,"title":["Cerium-Rutin Coordination Polymer Nanoparticles for Scavenging ROS and Inhibiting Amyloid-\u03b2 Fibrillation in Alzheimer's Disease"],"prefix":"10.1021","volume":"18","author":[{"given":"Pian","family":"Yu","sequence":"first","affiliation":[{"name":"Xiangya Hospital, Central South University , , 87 Xiangya Road , , ,","place":["Changsha, Hunan Province, China, 410008"]},{"name":"Xiangya Hospital, Central South University , , 87 Xiangya Road , , ,","place":["Changsha, Hunan Province, China, 410008"]},{"name":"Xiangya Hospital , , 87 Xiangya Road , , ,","place":["Changsha, Hunan Province, China, 410008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangdong Medical University , , , ,","place":["Dongguan, Guangdong, China, 523808"]},{"name":"The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University , , ,","place":["Dongguan, Guangdong, China, 523326"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiong","family":"Qiu","sequence":"additional","affiliation":[{"name":"The Tenth Affiliated Hospital of Southern Medical University , , ,","place":["Dongguan, China, 523059"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Fu","sequence":"additional","affiliation":[{"name":"Guangdong Medical University , , , ,","place":["Dongguan, Guangdong, China, 523808"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yu","sequence":"additional","affiliation":[{"name":"Xiangya Hospital, Central South University , , 87 Xiangya Road , , ,","place":["Changsha, Hunan Province, China, 410008"]},{"name":"Xiangya Hospital, Central South University , , 87 Xiangya Road , , ,","place":["Changsha, Hunan Province, China, 410008"]},{"name":"Xiangya Hospital , , 87 Xiangya Road , , ,","place":["Changsha, Hunan Province, China, 410008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangdong Medical University , , , ,","place":["Dongguan, Guangdong, China, 523808"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Deng","sequence":"additional","affiliation":[{"name":"Guangdong Medical University , , , ,","place":["Dongguan, Guangdong, China, 523808"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Medical University , , , ,","place":["Dongguan, Guangdong, China, 523808"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshuai","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Medical University , , , ,","place":["Dongguan, Guangdong, China, 523808"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Medical University , , , ,","place":["Dongguan, Guangdong, China, 523808"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Huang","sequence":"additional","affiliation":[{"name":"Xiangya Hospital, Central South University , , 87 Xiangya Road , , ,","place":["Changsha, Hunan Province, China, 410008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Cui","sequence":"additional","affiliation":[{"name":"Guangdong Medical University , , , ,","place":["Dongguan, Guangdong, China, 523808"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5645-697X","authenticated-orcid":true,"given":"Xiaoxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Xiangya Hospital, Central South University , , 87 Xiangya Road , , ,","place":["Changsha, Hunan Province, China, 410008"]},{"name":"Xiangya Hospital, Central South University , , 87 Xiangya Road , , ,","place":["Changsha, Hunan Province, China, 410008"]},{"name":"Xiangya Hospital , , 87 Xiangya Road , , ,","place":["Changsha, Hunan Province, China, 410008"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"issue":"8","key":"2026092321470035400_cit1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/s43587-022-00269-x","article-title":"Designing the next-generation clinical care pathway for Alzheimer's disease","volume":"2","author":"Hampel","year":"2022","journal-title":"Nat. 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