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Here, we report AggreArch, a tunable aqueous nano-to-micro assembly platform for constructing hierarchical metal-based microarchitectures with programmable composition, morphology, and biological activity. Using this strategy, we generated Ag-, Cu-, and Mn-based AggreArch variants to demonstrate the compositional extensibility of the platform. Among these variants, the dendritic silver architecture AAAg4 was identified as a representative lead candidate, achieving 99.7% inhibition against multidrug-resistant Escherichia coli (E. coli) at 30 \u03bcg mL\u22121 and 99.8% inhibition against methicillin-resistant Staphylococcus aureus (S. aureus) at 100 \u03bcg mL\u22121, while maintaining &amp;gt;85% cell viability and favorable short-term biosafety. Comparative release studies showed that AAAg4 released only 1\u20132% of total silver in PBS over 7 days vs \u223c7% for conventional AgNPs, confirming architecture-regulated silver availability. Integrated transcriptomic and biochemical analyses indicated that AAAg4 induced a coordinated redox-metabolic stress program involving oxidative imbalance, Fe-S-dependent functions, and respiratory electron-transfer-related processes, while imposing a lower oxidative burden on host cells than freely available Ag+. In diabetic infected wound models, AAAg4 accelerated wound closure (approximately 92% by day 12), markedly reduced bacterial burden, and enhanced collagen deposition to 83.1% vs 36.1% in controls. Similar repair-promoting trends were observed in rabbit ear wounds. Collectively, these findings establish AAAg4 as a representative lead architecture within the AggreArch platform and demonstrate that hierarchical microarchitecture engineering can expand the antibacterial-biosafety window of metal-based wound-facing antimicrobial materials.<\/jats:p>","DOI":"10.1021\/acsami.6c13004","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T18:02:01Z","timestamp":1787248921000},"page":"46847-46872","source":"Crossref","is-referenced-by-count":0,"title":["AggreArch: A Programmable Nano-to-Micro Assembly Platform for Redox-Active Metal Microarchitectures in Infected Wound Repair"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1014-1280","authenticated-orcid":true,"given":"Xuanshuo","family":"Zhang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University) , Zheshan West Road , , ,","place":["Wuhu, Anhui, China, 241001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University) , Zheshan West Road , , ,","place":["Wuhu, Anhui, China, 241001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyu","family":"Xu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University) , Zheshan West Road , , ,","place":["Wuhu, Anhui, China, 241001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University) , Zheshan West Road , , ,","place":["Wuhu, Anhui, China, 241001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyi","family":"Qian","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University) , Zheshan West Road , , ,","place":["Wuhu, Anhui, China, 241001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Chen","sequence":"additional","affiliation":[{"name":"Guanchao Medical Research Institute of Xiamen , ,","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeping","family":"Gui","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Nanjing Medical University , ,","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guanchao Medical Research Institute of Xiamen , ,","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"He","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University) , Zheshan West Road , , ,","place":["Wuhu, Anhui, China, 241001"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"issue":"9","key":"2026090311171639300_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11092526","article-title":"Cellular and Molecular Processes in Wound Healing","volume":"11","author":"Fern\u00e1ndez-Guarino","year":"2023","journal-title":"Biomedicines"},{"issue":"10","key":"2026090311171639300_cit2","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70406","article-title":"Diabetic Wound Repair: From Mechanism to Therapeutic Opportunities","volume":"6","author":"Wang","year":"2025","journal-title":"MedComm"},{"issue":"03","key":"2026090311171639300_cit3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1055\/s-0041-1731460","article-title":"Updates in Diabetic Wound Healing, Inflammation, and Scarring","volume":"35","author":"Dasari","year":"2021","journal-title":"Semin. 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