{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:46:08Z","timestamp":1792784768340,"version":"4.5.0"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2024ZD0530900"],"award-info":[{"award-number":["2024ZD0530900"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Transformation Foundation of Tianfu Jincheng Laboratory","award":["2025ZH009"],"award-info":[{"award-number":["2025ZH009"]}]},{"name":"Chengdu Municipal Health Commission Medical Research Project","award":["2026200"],"award-info":[{"award-number":["2026200"]}],"id":[{"id":"https:\/\/ror.org\/00cs48e65","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["32471474"],"award-info":[{"award-number":["32471474"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["82474453"],"award-info":[{"award-number":["82474453"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Department of Science and Technology of Sichuan Province","award":["2024YFFK0063"],"award-info":[{"award-number":["2024YFFK0063"]}]},{"name":"Department of Science and Technology of Sichuan Province","award":["2025YFHZ0086"],"award-info":[{"award-number":["2025YFHZ0086"]}]},{"name":"Department of Science and Technology of Sichuan Province","award":["2025ZNSFSC0381"],"award-info":[{"award-number":["2025ZNSFSC0381"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intracerebral hemorrhage (ICH) remains a highly lethal and disabling subtype of stroke, and the lack of effective disease-modifying therapies largely reflects the complexity of its secondary injury mechanisms: oxidative stress predominates early and fuels neuroinflammation, whereas impaired neurorepair persists into the subacute phase. Microglia orchestrate these stage-dependent responses and represent a tractable target for shifting perihematomal pathology from damage amplification toward repair. In this study, we developed an injectable, reactive oxygen species (ROS)-responsive therapeutic platform that combines local ROS scavenging with low-intensity-focused ultrasound (LIFU)-enhanced delivery of immunomodulatory and neurotrophic cues. A self-curing polyvinyl alcohol (PVA)-TSPBA hydrogel, hereafter referred to as PT, was engineered to scavenge ROS and to co-encapsulate IL-4 with porous PLGA microspheres containing NT-3, forming IL4-NT3@PT, which gelled rapidly within the operational observation window, exhibited brain-compatible mechanics, showed CSF-like degradability, and scavenged H2O2. In vitro, IL4-NT3@PT reduced oxidative burden and corrected pro-inflammatory microglial bias, with stronger effects after LIFU triggering. In vivo, LIFU-triggered IL4\/NT3@PT accelerated lesion resolution and improved motor recovery, while transcriptomic and histological analyses supported immune-network reprogramming, attenuation of oxidative stress and neuroinflammation, reduced microglial activation, and improved tissue preservation. An ultrasound-actuated, injectable ROS-scavenging hydrogel platform enabling sequential IL-4\/NT-3 delivery provides a minimally invasive platform for phase-adapted intervention in hemorrhagic brain injury.<\/jats:p>","DOI":"10.1021\/acsami.6c13056","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:26:48Z","timestamp":1788215208000},"page":"47508-47525","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound-Programmable ROS-Responsive Hydrogel Orchestrates Staged Immunomodulation and Neurorepair after Intracerebral Hemorrhage"],"prefix":"10.1021","volume":"18","author":[{"given":"Ruiying","family":"Han","sequence":"first","affiliation":[{"name":"Southern Medical University , , 366, Jiangnan Avenue South , ,","place":["Guangzhou, China, 510280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsen","family":"He","sequence":"additional","affiliation":[{"name":"Sichuan Lansheng Brain Hospital & Shanghai Lansheng Brain Hospital Investment Co., Ltd. , , 6 Anrong Road, Chadianzi Street, Jinniu District , , ,","place":["Chengdu, Sichuan, China, 610036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglin","family":"He","sequence":"additional","affiliation":[{"name":"Xiangya Hospital, Central South University , , , ,","place":["Changsha, Hunan, PR China, 410008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Chongqing Medical University , ,","place":["Chongqing, China, 400010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Chongqing Medical University , ,","place":["Chongqing, China, 400010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[{"name":"Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , , No. 32, West Section 2, First Ring Road , , ,","place":["Chengdu, Sichuan, China, 610072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Cui","sequence":"additional","affiliation":[{"name":"Mianyang Orthopedic Hospital , ,","place":["Mianyang, China, 621000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Yang","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University , , , ,","place":["Chengdu, Sichuan, China, 610065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chufeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Southern Medical University , , 366, Jiangnan Avenue South , ,","place":["Guangzhou, China, 510280"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wu","sequence":"additional","affiliation":[{"name":"Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China , , No. 32, West Section 2, First Ring Road , , ,","place":["Chengdu, Sichuan, China, 610072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-3224","authenticated-orcid":true,"given":"Changchun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Sichuan University, Institute of Regulatory Science for Medical Devices , , ,","place":["Chengdu, China, 610065"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"2026091612075152400_cit1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41572-023-00424-7","article-title":"Intracerebral Haemorrhage","volume":"9","author":"Puy","year":"2023","journal-title":"Nat. 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