{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:51:52Z","timestamp":1791399112846,"version":"4.3.3"},"reference-count":60,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo Municipality","doi-asserted-by":"publisher","award":["2024J117"],"award-info":[{"award-number":["2024J117"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M771443"],"award-info":[{"award-number":["2025M771443"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012543","name":"Shanghai Science and Technology Development Foundation","doi-asserted-by":"publisher","award":["25ZR1402024"],"award-info":[{"award-number":["25ZR1402024"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171168"],"award-info":[{"award-number":["32171168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32350610248"],"award-info":[{"award-number":["32350610248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371243"],"award-info":[{"award-number":["32371243"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571372"],"award-info":[{"award-number":["32571372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Accurate differentiation between moyamoya disease (MMD) and intracranial atherosclerotic disease (ICAD) remains clinically challenging yet crucial for guiding effective therapeutic strategies. Here, we developed a novel nanomaterial platform (SCs-ZIF-8@Au) to perform high-resolution serum metabolic fingerprinting using nanoparticle-assisted laser desorption\/ionization mass spectrometry. By integrating machine learning algorithms with metabolic profiling, we established a robust diagnostic model that accurately distinguished MMD from ICAD and healthy controls (HCs). In a cohort comprising 178 MMD patients, 75 ICAD patients, and 103 HCs, our classifier achieved area under the curve (AUC) values of 0.97 (MMD vs HCs), 0.98 (ICAD vs HCs), and 0.88 (MMD vs ICAD). Beyond diagnostics, mechanistic exploration of key metabolic biomarkers revealed that reduced mevalonic acid in MMD impairs endothelial tube formation and migration by disrupting tight junction integrity, attenuating VEGF signaling, and altering calcium homeostasis in human endothelial cells. These findings link dysregulated mevalonate metabolism to pathological angiogenesis in MMD and support its role in endothelial dysfunction. Together, our study provides a clinically applicable, noninvasive diagnostic tool for MMD and ICAD, while uncovering a previously unrecognized pathogenic mechanism that connects systemic metabolic alterations to cerebrovascular remodeling in MMD.<\/jats:p>","DOI":"10.1021\/acsami.6c13089","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:02:08Z","timestamp":1791396128000},"source":"Crossref","is-referenced-by-count":0,"title":["Integrated Diagnostic and Mechanistic Profiling of Moyamoya and Intracranial Atherosclerotic Disease via Serum Metabolic Fingerprinting Based on SCs-ZIF-8@Au Nanomaterials"],"prefix":"10.1021","author":[{"given":"Xinmei","family":"Wang","sequence":"first","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 200120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangmin","family":"He","sequence":"additional","affiliation":[{"name":"Fudan University, Huashan Hospital , , ,","place":["Shanghai, China, 200040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Yang","family":"Luo","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital, Fudan University , , ,","place":["Shanghai, China, 200438"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Fudan University, Huashan Hospital , , ,","place":["Shanghai, China, 200040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindian","family":"Xu","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 200120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Gu","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital, Fudan University , , ,","place":["Shanghai, China, 200438"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Ji","sequence":"additional","affiliation":[{"name":"Fudan University, Huashan Hospital , , ,","place":["Shanghai, China, 200040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1857-112X","authenticated-orcid":true,"given":"Yan","family":"Xia","sequence":"additional","affiliation":[{"name":"NingboTech University , , ,","place":["Ningbo, China, 315100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Fudan University, Huashan Hospital , , ,","place":["Shanghai, China, 200040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-8709","authenticated-orcid":true,"given":"Li-Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital, Fudan University , , ,","place":["Shanghai, China, 200438"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-9766","authenticated-orcid":true,"given":"Jiaxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 200120"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"issue":"4","key":"2026100714015876900_cit1","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1136\/svn-2021-000909","article-title":"Incidence and Prevalence of Moyamoya Disease in Urban China: A Nationwide Retrospective Cohort Study","volume":"6","author":"Sun","year":"2021","journal-title":"Stroke Vasc. Neurol."},{"issue":"12","key":"2026100714015876900_cit2","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1056\/NEJMra0804622","article-title":"Moyamoya Disease and Moyamoya Syndrome","volume":"360","author":"Scott","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"2026100714015876900_cit3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.2176\/nmc.52.245","article-title":"Guidelines for Diagnosis and Treatment of Moyamoya Disease (Spontaneous Occlusion of the Circle of Willis)","volume":"52","author":"Research Committee on the Pathology and Treatment of Spontaneous Occlusion of the Circle of Willis","year":"2012","journal-title":"Neurol. Med. Chir."},{"issue":"8","key":"2026100714015876900_cit4","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S1474-4422(22)00165-X","article-title":"Moyamoya Disease: Diagnosis and Interventions","volume":"21","author":"Ihara","year":"2022","journal-title":"Lancet Neurol."},{"issue":"1","key":"2026100714015876900_cit5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.31662\/jmaj.2022-0104","article-title":"The Pathogenetic Mechanism for Moyamoya Vasculopathy Including a Possible Trigger Effect of Increased Flow Velocity","volume":"6","author":"Abumiya","year":"2023","journal-title":"JMA J."},{"issue":"1","key":"2026100714015876900_cit6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.5853\/jos.2015.01760","article-title":"The Pathophysiology of Moyamoya Disease: An Update","volume":"18","author":"Bang","year":"2016","journal-title":"J. Stroke"},{"key":"2026100714015876900_cit7","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202405580","article-title":"Non-Invasive Diagnosis of Moyamoya Disease Using Serum Metabolic Fingerprints and Machine Learning","volume":"12","author":"Weng","year":"2025","journal-title":"Adv. Sci."},{"issue":"9","key":"2026100714015876900_cit8","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1035","article-title":"Circulating Endothelial Progenitor Cells and Endothelial Cells in Moyamoya Disease","volume":"8","author":"Bao","year":"2018","journal-title":"Brain Behav."},{"key":"2026100714015876900_cit9","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.661952","article-title":"Non-Invasive Urinary Biomarkers in Moyamoya Disease","volume":"12","author":"Sesen","year":"2021","journal-title":"Front. Neurol."},{"key":"2026100714015876900_cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1156894","article-title":"APOE as Potential Biomarkers of Moyamoya Disease","volume":"14","author":"Wu","year":"2023","journal-title":"Front. Neurol."},{"key":"2026100714015876900_cit11","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00308","article-title":"Metabolomic Profiling Revealed Potential Biomarkers in Patients With Moyamoya Disease","volume":"14","author":"Geng","year":"2020","journal-title":"Front. Neurosci."},{"issue":"1","key":"2026100714015876900_cit12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-112","article-title":"Identification of Novel Biomarker Candidates by Proteomic Analysis of Cerebrospinal Fluid from Patients with Moyamoya Disease Using SELDI-TOF-MS","volume":"10","author":"Araki","year":"2010","journal-title":"BMC Neurol."},{"issue":"2","key":"2026100714015876900_cit13","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1161\/STROKEAHA.123.043630","article-title":"Epidemiology, Pathophysiology, and Imaging of Atherosclerotic Intracranial Disease","volume":"55","author":"Chen","year":"2024","journal-title":"Stroke"},{"key":"2026100714015876900_cit14","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2010.00119","article-title":"Middle Cerebral Artery Stenosis Associated with Moyamoya Pattern Collateralization","volume":"1","author":"Edgell","year":"2010","journal-title":"Front. Neurol."},{"issue":"1","key":"2026100714015876900_cit15","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-022-01539-6","article-title":"Microsurgical Treatment of Middle Cerebral Artery Stenosis or Occlusion: A Single Center Experience and Literature Review","volume":"22","author":"Zhang","year":"2022","journal-title":"BMC Surg."},{"issue":"6","key":"2026100714015876900_cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106481","article-title":"Characterization of Moyamoya and Middle Cerebral Artery Diseases by Carotid Canal Diameter and RNF213 pR4810K Genotype","volume":"31","author":"Oichi","year":"2022","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"18","key":"2026100714015876900_cit17","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1001\/jama.2011.1610","article-title":"Extracranial-Intracranial Bypass Surgery for Stroke Prevention in Hemodynamic Cerebral Ischemia: The Carotid Occlusion Surgery Study Randomized Trial","volume":"306","author":"Powers","year":"2011","journal-title":"JAMA"},{"key":"2026100714015876900_cit18","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1097\/JS9.0000000000002092","article-title":"In-Depth Cerebrovascular Lipidomics Pro\ufb01ling for Discovering Novel Biomarkers and Mechanisms in Moyamoya and Intracranial Atherosclerotic Disease","volume":"111","author":"He","year":"2025","journal-title":"Int. J. Surg."},{"issue":"27","key":"2026100714015876900_cit19","doi-asserted-by":"publisher","first-page":"10831","DOI":"10.1002\/anie.202001135","article-title":"FeOOH@Metal-Organic Framework Core-Satellite Nanocomposites for the Serum Metabolic Fingerprinting of Gynecological Cancers","volume":"59","author":"Pei","year":"2020","journal-title":"Angew. Chem., Int. Ed. Engl."},{"issue":"1","key":"2026100714015876900_cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17347-6","article-title":"Machine Learning of Serum Metabolic Patterns Encodes Early-Stage Lung Adenocarcinoma","volume":"11","author":"Huang","year":"2020","journal-title":"Nat. Commun."},{"issue":"6","key":"2026100714015876900_cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2022.107992","article-title":"Metal-Organic Framework Nanofilm Enhances Serum Metabolic Profiles for Diagnosis and Subtype of Cardiovascular Disease","volume":"34","author":"Ouyang","year":"2023","journal-title":"Chin. Chem. Lett."},{"issue":"17","key":"2026100714015876900_cit22","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007978","article-title":"Plasmonic Alloys Reveal a Distinct Metabolic Phenotype of Early Gastric Cancer","volume":"33","author":"Su","year":"2021","journal-title":"Adv. Mater."},{"issue":"1","key":"2026100714015876900_cit23","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1039\/d3sc05633c","article-title":"Organic Metal Chalcogenide-Assisted Metabolic Molecular Diagnosis of Central Precocious Puberty","volume":"15","author":"Ouyang","year":"2024","journal-title":"Chem. Sci."},{"key":"2026100714015876900_cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102428","article-title":"Serum and Urine Metabolic Fingerprints Enable Diagnosis and Prognosis for IgA Nephropathy","volume":"35","author":"Wang","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"39","key":"2026100714015876900_cit25","doi-asserted-by":"publisher","first-page":"21530","DOI":"10.1021\/acs.analchem.5c03796","article-title":"Stacking-Directed Energy Modulation in Covalent Organic Framework Thin Films for Enhanced Serum Metabolic Profiling of Mycoplasma Pneumoniae Infection by Laser Desorption\/Ionization Mass Spectrometry","volume":"97","author":"Jin","year":"2025","journal-title":"Anal. Chem."},{"key":"2026100714015876900_cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101857","article-title":"Efficient Metabolic Fingerprinting Profiling of Extracellular Vesicles for Precise Cancer Diagnosis and Treatment Monitoring","volume":"32","author":"Wang","year":"2025","journal-title":"Mater. Today Bio."},{"key":"2026100714015876900_cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102712","article-title":"Primary Tissue Metabolic Fingerprinting for Efficient Diagnosis of Lymph Node Metastasis and Metabolic Reprogramming Mechanisms in Colorectal Cancer","volume":"36","author":"Zhang","year":"2026","journal-title":"Mater. Today Bio"},{"issue":"1","key":"2026100714015876900_cit28","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","article-title":"Angiogenic Signaling Pathways and Anti-Angiogenic Therapy for Cancer","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"Suppl 2","key":"2026100714015876900_cit29","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1016\/s0303-8467(97)00032-2","article-title":"Epidemiological Survey of Moyamoya Disease in Korea","volume":"99","author":"Ikezaki","year":"1997","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"9","key":"2026100714015876900_cit30","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1212\/01.wnl.0000210530.46058.5c","article-title":"Impact of Metabolic Syndrome on Prognosis of Symptomatic Intracranial Atherostenosis","volume":"66","author":"Ovbiagele","year":"2006","journal-title":"Neurology"},{"issue":"8","key":"2026100714015876900_cit31","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.04.010","article-title":"Impact of Hypertriglyceridemia on Carotid Stenosis Progression under Normal Low-Density Lipoprotein Cholesterol Levels","volume":"26","author":"Kitagami","year":"2017","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"6","key":"2026100714015876900_cit32","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1093\/neuros\/nyaa284","article-title":"Clinical Course of Unilateral Moyamoya Disease","volume":"87","author":"Church","year":"2020","journal-title":"Neurosurgery"},{"issue":"8","key":"2026100714015876900_cit33","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1161\/STROKEAHA.120.030027","article-title":"Modifiable Risk Factors Associated With Moyamoya Disease: A Case-Control Study","volume":"51","author":"Ge","year":"2020","journal-title":"Stroke"},{"issue":"1","key":"2026100714015876900_cit34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2176\/nmc.47.1","article-title":"Histological Features of Middle Cerebral Arteries from Patients Treated for Moyamoya Disease","volume":"47","author":"Takagi","year":"2007","journal-title":"Neurol. Med. Chir."},{"issue":"2","key":"2026100714015876900_cit35","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.10.004","article-title":"Differential Expression of Vascular Endothelial Growth Factor-A165 Isoforms Between Intracranial Atherosclerosis and Moyamoya Disease","volume":"28","author":"Jiang","year":"2019","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"1","key":"2026100714015876900_cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05664-8","article-title":"Prospective Evaluation of the Diagnostic Value of Plasma Apelin 12 Levels for Differentiating Patients with Moyamoya and Intracranial Atherosclerotic Diseases","volume":"7","author":"Hu","year":"2017","journal-title":"Sci. Rep."},{"key":"2026100714015876900_cit37","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9792412","article-title":"Serum Uric Acid and Triglycerides in Chinese Patients with Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study","volume":"2019","author":"Ma","year":"2019","journal-title":"Biomed. Res. Int."},{"issue":"3","key":"2026100714015876900_cit38","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1083\/jcb.201712120","article-title":"The AAA+ ATPase\/Ubiquitin Ligase Mysterin Stabilizes Cytoplasmic Lipid Droplets","volume":"218","author":"Sugihara","year":"2019","journal-title":"J. Cell Biol."},{"key":"2026100714015876900_cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2024.108403","article-title":"Routine Screening Serum Tests to Detect Underlying Thyroid and Autoimmune Diseases in Patients with Moyamoya Disease","volume":"243","author":"Ito","year":"2024","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"4","key":"2026100714015876900_cit40","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1161\/STROKEAHA.110.608471","article-title":"Increased Thyroid Function and Elevated Thyroid Autoantibodies in Pediatric Patients with Moyamoya Disease: A Case-Control Study","volume":"42","author":"Li","year":"2011","journal-title":"Stroke"},{"issue":"8","key":"2026100714015876900_cit41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220858","article-title":"Identification of HLA-DRB1*04:10 Allele as Risk Allele for Japanese Moyamoya Disease and Its Association with Autoimmune Thyroid Disease: A Case-Control Study","volume":"14","author":"Tashiro","year":"2019","journal-title":"PLoS One"},{"issue":"6","key":"2026100714015876900_cit42","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.jstrokecerebrovasdis.2010.03.006","article-title":"Moyamoya Syndrome Associated with Graves\u2019 Disease: A Case Report and Review of the Literature","volume":"20","author":"Malik","year":"2011","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"7","key":"2026100714015876900_cit43","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric Oxide Synthases: Regulation and Function","volume":"33","author":"F\u00f6rstermann","year":"2012","journal-title":"Eur. Heart J."},{"key":"2026100714015876900_cit44","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1146\/annurev.nu.09.070189.001443","article-title":"Nutritional and Metabolic Aspects of Glutathione","volume":"9","author":"Beutler","year":"1989","journal-title":"Annu. Rev. Nutr."},{"issue":"4","key":"2026100714015876900_cit45","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/bph.14446","article-title":"Regulators of the Transsulfuration Pathway","volume":"176","author":"Sbodio","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"2026100714015876900_cit46","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1177\/014107680109400103","article-title":"Homocysteine--a Novel Risk Factor for Vascular Disease","volume":"94","author":"Chambers","year":"2001","journal-title":"J. R. Soc. Med."},{"issue":"7443","key":"2026100714015876900_cit47","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature12040","article-title":"Glutamine Supports Pancreatic Cancer Growth through a KRAS-Regulated Metabolic Pathway","volume":"496","author":"Son","year":"2013","journal-title":"Nature"},{"issue":"1","key":"2026100714015876900_cit48","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03640-3","article-title":"Plasma Glutamine Status at Intensive Care Unit Admission: An Independent Risk Factor for Mortality in Critical Illness","volume":"25","author":"Smedberg","year":"2021","journal-title":"Crit. Care"},{"issue":"17","key":"2026100714015876900_cit49","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000629","article-title":"1H-NMR-Based Metabolomic Analysis of Cerebrospinal Fluid from Adult Bilateral Moyamoya Disease: Comparison with Unilateral Moyamoya Disease and Atherosclerotic Stenosis","volume":"94","author":"Jeon","year":"2015","journal-title":"Medicine"},{"issue":"5","key":"2026100714015876900_cit50","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.525","article-title":"High Glutamine Increases Stroke Risk by Inducing the Endothelial-to-Mesenchymal Transition in Moyamoya Disease","volume":"5","author":"He","year":"2024","journal-title":"MedComm"},{"issue":"11","key":"2026100714015876900_cit51","doi-asserted-by":"publisher","first-page":"5134","DOI":"10.1016\/S0021-9258(19)70760-1","article-title":"Relation of Cholesterol and Mevalonic Acid to the Cell Cycle in Smooth Muscle and Swiss 3T3 Cells Stimulated to Divide by Platelet-Derived Growth Factor","volume":"255","author":"Habenicht","year":"1980","journal-title":"J. Biol. Chem."},{"key":"2026100714015876900_cit52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0378-4274(92)90167-i","article-title":"Cholesterol and Mevalonic Acid Modulation in Cell Metabolism and Multiplication","volume":"64\u201365","author":"Soma","year":"1992","journal-title":"Toxicol Lett."},{"key":"2026100714015876900_cit53","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3969\/j.issn.0559-7765.2021.03.005","article-title":"Research progress of tight junction in vascular endothelial cells","volume":"3","author":"Zhang","year":"2021","journal-title":"Prog. Physiol. Sci."},{"issue":"4","key":"2026100714015876900_cit54","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/cne.10653","article-title":"Nectin-Dependent Localization of ZO-1 at Puncta Adhaerentia Junctions between the Mossy Fiber Terminals and the Dendrites of the Pyramidal Cells in the CA3 Area of Adult Mouse Hippocampus","volume":"460","author":"Inagaki","year":"2003","journal-title":"J. Comp. Neurol."},{"issue":"4","key":"2026100714015876900_cit55","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/s0092-8674(02)00731-6","article-title":"Antagonism between Ena\/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility","volume":"109","author":"Bear","year":"2002","journal-title":"Cell"},{"issue":"12","key":"2026100714015876900_cit56","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1038\/ncb1502","article-title":"Regulation of Cell Shape by Cdc42 Is Mediated by the Synergic Actin-Bundling Activity of the Eps8\u2013IRSp53 Complex","volume":"8","author":"Disanza","year":"2006","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"2026100714015876900_cit57","doi-asserted-by":"publisher","first-page":"895","DOI":"10.3109\/01902148909069634","article-title":"Membrane Perturbations and Mediation of Gap Junction Formation in Response to Taurine Treatment in Normal and Injured Alveolar Epithelia","volume":"15","author":"Gordon","year":"1989","journal-title":"Exp. Lung Res."},{"key":"2026100714015876900_cit58","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00449","article-title":"Taurine Alleviates Intestinal Injury by Mediating Tight Junction Barriers in Diquat-Challenged Piglet Models","volume":"11","author":"Wen","year":"2020","journal-title":"Front. Physiol."},{"issue":"23","key":"2026100714015876900_cit59","doi-asserted-by":"publisher","first-page":"8113","DOI":"10.1128\/MCB.00794-07","article-title":"Identification of Phosphotyrosine Binding Domain-Containing Proteins as Novel Downstream Targets of the EphA8 Signaling Function","volume":"27","author":"Shin","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"3","key":"2026100714015876900_cit60","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/ncb2705","article-title":"Endocytosis Regulates VEGF Signalling during Angiogenesis","volume":"15","author":"Gaengel","year":"2013","journal-title":"Nat. Cell Biol."}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c13089","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/doi\/10.1021\/acsami.6c13089\/68778329\/am-2026-13089s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/doi\/10.1021\/acsami.6c13089\/68778329\/am-2026-13089s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:10:32Z","timestamp":1791396632000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/doi\/10.1021\/acsami.6c13089\/5446539\/Integrated-Diagnostic-and-Mechanistic-Profiling-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":60,"URL":"https:\/\/doi.org\/10.1021\/acsami.6c13089","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]}}}