{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:52:34Z","timestamp":1791967954511,"version":"4.3.4"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Anusandhan National Research Foundation","doi-asserted-by":"publisher","award":["PDF\/2025\/000046"],"award-info":[{"award-number":["PDF\/2025\/000046"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clinical oncology faces a critical technological bottleneck driven by the rapid emergence of therapy-resistant tumors. Melanoma, in particular, remains a highly aggressive malignancy with pronounced metastatic potential and poor responsiveness to traditional therapy, signify the demand for advanced therapeutic strategies. Herein, we report a multifunctional nanoplatform integrating ternary layered double hydroxides (LDHs) with an injectable hydrogel system for localized and controlled melanoma therapy. The engineered trimetallic Cu\u2013Zn\u2013Fe LDHs (CZF) exhibit tunable physicochemical properties, enabling efficient drug intercalation, enhanced structural stability, and stimuli-responsive release within the tumor microenvironment. Doxorubicin (Dox) loaded LDHs (CZF@Dox) demonstrate high loading efficiency and sustained release, minimizing premature leakage and systemic toxicity. Computational insights from molecular dynamics and machine learning-assisted modeling reveal optimized host\u2013guest interactions for improved delivery performance. In vitro studies confirm excellent biocompatibility toward normal 3T3-L1 cells (\u223c10% cell death at 20 \u03bcg\/mL, 72 h), alongside significant cytotoxicity against B16F10 and SiHa cancer cells (\u223c80\u201385% cell death at the same conditions). In vivo evaluation further demonstrates effective tumor suppression with prolonged dosing intervals (96 h). Overall, this platform offers a predictive, minimally invasive, and efficient strategy for next-generation melanoma therapy.<\/jats:p>","DOI":"10.1021\/acsami.6c13200","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:01:17Z","timestamp":1791248477000},"page":"54547-54569","source":"Crossref","is-referenced-by-count":0,"title":["Trimetallic Cu\u2013Zn\u2013Fe Layered Double Hydroxide Nanocarrier Enabling On-Demand Anticancer Drug Release with Prolonged Therapeutic Windows for Precision Oncology"],"prefix":"10.1021","volume":"18","author":[{"given":"Swapan","family":"Maity","sequence":"first","affiliation":[{"name":"University of Calcutta , , 92 A.P.C. Road , ,","place":["Kolkata, India, 700009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souvik","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology (Banaras Hindu University) , , ,","place":["Varanasi, India, 221005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipesh Kumar","family":"Dubey","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology (Banaras Hindu University) , , ,","place":["Varanasi, India, 221005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitesh Harsukhbhai","family":"Chandpa","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology (Banaras Hindu University) , , ,","place":["Varanasi, India, 221005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7625-6817","authenticated-orcid":true,"given":"Jairam","family":"Meena","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology (Banaras Hindu University) , , ,","place":["Varanasi, India, 221005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshita","family":"Upreti","sequence":"additional","affiliation":[{"name":"Birla Institute of Technology and Science, Pilani (K. K Birla Goa Campus) , , ,","place":["Goa, India, 403726"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan Chand","family":"Sahu","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology (Banaras Hindu University) , , ,","place":["Varanasi, India, 221005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Kumar","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology (Banaras Hindu University) , , ,","place":["Varanasi, India, 221005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manas Kumar","family":"Santra","sequence":"additional","affiliation":[{"name":"National Centre for Cell Science , , ,","place":["Pune, Maharashtra, India, 411007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0863-5882","authenticated-orcid":true,"given":"Dipankar","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"University of Calcutta , , 92 A.P.C. Road , ,","place":["Kolkata, India, 700009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2099-452X","authenticated-orcid":true,"given":"Arun Kumar","family":"Nandi","sequence":"additional","affiliation":[{"name":"Indian Association for the Cultivation of Science , , ,","place":["Jadavpur, India, 700 032"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6879-3591","authenticated-orcid":true,"given":"Pralay","family":"Maiti","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology (Banaras Hindu University) , , ,","place":["Varanasi, India, 221005"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"2026101404073675700_cit1","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1007\/978-3-031-28780-0_60","volume-title":"Bioprospecting of tropical medicinal plants","author":"Ghufran","year":"2023"},{"key":"2026101404073675700_cit2","doi-asserted-by":"publisher","DOI":"10.1177\/10732748211038735","article-title":"Cancer biology, epidemiology, and treatment in the 21st century: current status and future challenges from a biomedical perspective","volume":"28","author":"Pina-Sanchez","year":"2021","journal-title":"Cancer Control"},{"issue":"1","key":"2026101404073675700_cit3","first-page":"10","article-title":"Cancer statistics","volume":"75","author":"Siegel","year":"2025","journal-title":"Ca"},{"issue":"3","key":"2026101404073675700_cit4","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1021\/acsabm.2c00002","article-title":"Recent progress in nanostructured smart drug delivery systems for cancer therapy: a review","volume":"5","author":"Khan","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"issue":"22","key":"2026101404073675700_cit5","doi-asserted-by":"publisher","first-page":"31046","DOI":"10.1021\/acsami.6c06529","article-title":"Functional Performance of Silk Nanoparticles for Oral Drug Delivery","volume":"18","author":"Jacobus","year":"2026","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"26","key":"2026101404073675700_cit6","doi-asserted-by":"publisher","first-page":"37383","DOI":"10.1021\/acsami.5c07366","article-title":"The Nanocarrier Landscape Evaluating Key Drug Delivery Vehicles and Their Capabilities: A Translational Perspective","volume":"17","author":"Khalid-Salako","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"2026101404073675700_cit7","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1021\/acsabm.5c00046","article-title":"Nanotechnology assisted drug delivery strategies for chemotherapy: recent advances and future prospects","volume":"8","author":"Yadav","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"issue":"10","key":"2026101404073675700_cit8","doi-asserted-by":"publisher","DOI":"10.3390\/nano9101404","article-title":"Functional layered double hydroxide nanohybrids for biomedical imaging","volume":"9","author":"Jin","year":"2019","journal-title":"Nanomaterials"},{"issue":"20","key":"2026101404073675700_cit9","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306035","article-title":"Layered double hydroxides: recent progress and promising perspectives toward biomedical applications","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci."},{"issue":"1","key":"2026101404073675700_cit10","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03448-1","article-title":"Layered double hydroxides for regenerative nanomedicine and tissue engineering: recent advances and future perspectives","volume":"23","author":"Luo","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"7","key":"2026101404073675700_cit11","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1021\/cr200434v","article-title":"Recent advances in the synthesis and application of layered double hydroxide (LDH) nanosheets","volume":"112","author":"Wang","year":"2012","journal-title":"Chem. Rev."},{"issue":"3","key":"2026101404073675700_cit12","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1002\/er.7335","article-title":"Recent developments in layered double hydroxide structures with their role in promoting photocatalytic hydrogen production: A comprehensive review","volume":"46","author":"Sherryna","year":"2022","journal-title":"Int. J. Energy Res."},{"key":"2026101404073675700_cit13","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.26717\/BJSTR.2018.2.000786","article-title":"Layered double hydroxides nanomaterials in biomedicine and (bio) sensing design","volume":"2","author":"Grosu","year":"2018","journal-title":"Biomed. J."},{"issue":"18","key":"2026101404073675700_cit14","doi-asserted-by":"publisher","first-page":"4873","DOI":"10.1039\/C6CS00343E","article-title":"Ultrathin two-dimensional layered metal hydroxides: an emerging platform for advanced catalysis, energy conversion and storage","volume":"45","author":"Yin","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"2026101404073675700_cit15","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.clay.2015.04.018","article-title":"Layered double hydroxide nanoparticles for biomedical applications: Current status and recent prospects","volume":"112","author":"Kuthati","year":"2015","journal-title":"Appl. Clay Sci."},{"issue":"10","key":"2026101404073675700_cit16","doi-asserted-by":"publisher","first-page":"4565","DOI":"10.1021\/acs.energyfuels.4c05376","article-title":"Advances in the Morphological Design and Dimensional Approaches of Layered Double Hydroxides for Photocatalytic Applications: A Critical Review","volume":"39","author":"Sherryna","year":"2025","journal-title":"Energy Fuels"},{"issue":"27","key":"2026101404073675700_cit17","doi-asserted-by":"publisher","first-page":"10365","DOI":"10.1039\/c4dt00573b","article-title":"Reactivity and applications of layered silicates and layered double hydroxides","volume":"43","author":"Selvam","year":"2014","journal-title":"Dalton Trans."},{"issue":"12","key":"2026101404073675700_cit18","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21121715","article-title":"Recent advances in stimuli-responsive release function drug delivery systems for tumor treatment","volume":"21","author":"Ding","year":"2016","journal-title":"Molecules"},{"issue":"5","key":"2026101404073675700_cit19","doi-asserted-by":"publisher","first-page":"7409","DOI":"10.3390\/ijms15057409","article-title":"Potential for layered double hydroxides-based, innovative drug delivery systems","volume":"15","author":"Zhang","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"2026101404073675700_cit20","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-527","article-title":"Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species","volume":"14","author":"Fatfat","year":"2014","journal-title":"BMC Cancer"},{"key":"2026101404073675700_cit21","doi-asserted-by":"publisher","first-page":"880","DOI":"10.17179\/excli2025-8449","article-title":"The role of redox-active iron, copper, manganese, and redox-inactive zinc in toxicity, oxidative stress, and human diseases","volume":"24","author":"Jomova","year":"2025","journal-title":"EXCLI J."},{"issue":"8","key":"2026101404073675700_cit22","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1016\/j.scitotenv.2011.01.015","article-title":"Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebrafish: acute toxicity, oxidative stress and oxidative damage","volume":"409","author":"Xiong","year":"2011","journal-title":"Sci. Total Environ."},{"key":"2026101404073675700_cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2025.117455","article-title":"Triple-cation CoPrFe-layered double hydroxide: Harnessing peroxidase-mimicking activity, antibacterial, and anticancer potentials in a single system","author":"Rashtbari","year":"2025","journal-title":"J. Environ. Chem. Eng."},{"issue":"4","key":"2026101404073675700_cit24","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.fmre.2022.06.001","article-title":"Ternary NiCoTi-layered double hydroxide nanosheets as a pH-responsive nanoagent for photodynamic\/chemodynamic synergistic therapy","volume":"4","author":"Hu","year":"2024","journal-title":"Fundam. Res."},{"issue":"27","key":"2026101404073675700_cit25","doi-asserted-by":"publisher","DOI":"10.1088\/1361-648X\/aa680e","article-title":"The atomic simulation environment\u2014a Python library for working with atoms","volume":"29","author":"Hjorth Larsen","year":"2017","journal-title":"J. Phys.: Condens. Matter"},{"key":"2026101404073675700_cit26","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2410.22570","article-title":"Orb: A fast, scalable neural network potential","volume-title":"arXiv","author":"Neumann","year":"2024"},{"issue":"1","key":"2026101404073675700_cit27","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-019-3055-2","article-title":"MOF-derived ZnSe\/N-doped carbon composites for lithium-ion batteries with enhanced capacity and cycling life","volume":"14","author":"Liu","year":"2019","journal-title":"Nanoscale Res. Lett."},{"issue":"7","key":"2026101404073675700_cit28","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1016\/j.apsusc.2010.10.051","article-title":"Resolving surface chemical states in XPS analysis of first row transition metals, oxides and hydroxides: Cr, Mn, Fe, Co and Ni","volume":"257","author":"Biesinger","year":"2011","journal-title":"Appl. Surf. Sci."},{"issue":"3","key":"2026101404073675700_cit29","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.apsusc.2010.07.086","article-title":"Resolving surface chemical states in XPS analysis of first row transition metals, oxides and hydroxides: Sc, Ti, V, Cu and Zn","volume":"257","author":"Biesinger","year":"2010","journal-title":"Appl. Surf. Sci."},{"key":"2026101404073675700_cit30","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.molstruc.2014.01.085","article-title":"Rapid identification of Pterocarpus santalinus and Dalbergia louvelii by FTIR and 2D correlation IR spectroscopy","volume":"1069","author":"Zhang","year":"2014","journal-title":"J. Mol. Struct."},{"issue":"18","key":"2026101404073675700_cit31","doi-asserted-by":"publisher","first-page":"4224","DOI":"10.1021\/jp0269975","article-title":"Two-dimensional ATR\u2013 FTIR spectroscopic investigation on water diffusion in polypropylene film: Water bending vibration","volume":"107","author":"Shen","year":"2003","journal-title":"J. Phys. Chem. B."},{"issue":"5\u20136","key":"2026101404073675700_cit32","doi-asserted-by":"publisher","first-page":"623","DOI":"10.2138\/am-2002-5-604","article-title":"Infrared and Raman study of interlayer anions CO32\u2013, NO3\u2013, SO42\u2013 and ClO4\u2013 in Mg\/Al-hydrotalcite","volume":"87","author":"Kloprogge","year":"2002","journal-title":"Am. Mineral."},{"issue":"13","key":"2026101404073675700_cit33","doi-asserted-by":"publisher","DOI":"10.3390\/nano13131943","article-title":"Porous hierarchical Ni\/Mg\/Al layered double hydroxide for adsorption of methyl orange from aqueous solution","volume":"13","author":"Waheed","year":"2023","journal-title":"Nanomaterials"},{"key":"2026101404073675700_cit34","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.cej.2014.04.105","article-title":"Magnetic Fe3O4\/MgAl-LDH composite for effective removal of three red dyes from aqueous solution","volume":"252","author":"Shan","year":"2014","journal-title":"Chem. Eng. J."},{"key":"2026101404073675700_cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.clay.2023.107195","article-title":"Nest-like NiFe-LDH derived from the ethylene glycol-assisted hydrothermal route: A highly efficient electrocatalyst for water oxidation in neutral solutions","volume":"246","author":"Rezvani","year":"2023","journal-title":"Appl. Clay Sci."},{"issue":"1","key":"2026101404073675700_cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-00437-w","article-title":"Understanding the physicochemical properties of Zn\u2013Fe LDH nanostructure as sorbent material for removing of anionic and cationic dyes mixture","volume":"11","author":"Mahmoud","year":"2021","journal-title":"Sci. Rep."},{"key":"2026101404073675700_cit37","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.chemosphere.2018.04.023","article-title":"Co-Mn layered double hydroxide as an effective heterogeneous catalyst for degradation of organic dyes by activation of peroxymonosulfate","volume":"204","author":"Zhao","year":"2018","journal-title":"Chemosphere"},{"issue":"1","key":"2026101404073675700_cit38","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s44307-024-00055-3","article-title":"Comparative study of Mg\/Al-LDH and Mg\/Fe-LDH on adsorption and loss control of 2, 4-dichlorophenoxyacetic acid","volume":"3","author":"Zhang","year":"2025","journal-title":"Adv. Biotechnol."},{"issue":"9","key":"2026101404073675700_cit39","doi-asserted-by":"publisher","DOI":"10.3390\/nano11092155","article-title":"Synthesis of CNTs\/CoNiFe-LDH nanocomposite with high specific surface area for asymmetric supercapacitor","volume":"11","author":"Wang","year":"2021","journal-title":"Nanomaterials"},{"issue":"10","key":"2026101404073675700_cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20976","article-title":"Montmorillonite modified Ni\/Mg\/Al ternary layered double hydroxide nanoflowers with enhanced adsorption features","volume":"9","author":"Waheed","year":"2023","journal-title":"Heliyon"},{"key":"2026101404073675700_cit41","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.apsusc.2016.11.032","article-title":"Novel synthesis of layered double hydroxides (LDHs) from zinc hydroxide","volume":"396","author":"Meng","year":"2017","journal-title":"Appl. Surf. Sci."},{"issue":"1","key":"2026101404073675700_cit42","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1021\/acssuschemeng.8b04476","article-title":"Surface area-and structure-dependent effects of LDH for highly efficient dye removal","volume":"7","author":"Gao","year":"2018","journal-title":"ACS Sustainable Chem. Eng."},{"issue":"10","key":"2026101404073675700_cit43","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.solidstatesciences.2006.03.006","article-title":"The layered double hydroxide (LDH) of Zn with Ga: Synthesis and reversible thermal behaviour","volume":"8","author":"Thomas","year":"2006","journal-title":"Solid State Sci."},{"key":"2026101404073675700_cit44","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00370","article-title":"pH sensing and regulation in cancer","volume":"4","author":"Damaghi","year":"2013","journal-title":"Front. Physiol."},{"issue":"1","key":"2026101404073675700_cit45","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.ab.2011.10.043","article-title":"Ammonia-containing dimethyl sulfoxide: An improved solvent for the dissolution of formazan crystals in the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay","volume":"421","author":"Wang","year":"2012","journal-title":"Anal. Biochem."},{"issue":"10","key":"2026101404073675700_cit46","doi-asserted-by":"publisher","first-page":"6377","DOI":"10.1021\/acsbiomaterials.4c01289","article-title":"Doxorubicin-intercalated Li\u2013Al-based LDHs as potential drug delivery nanovehicle with pH-responsive therapeutic cargo for tumor treatment","volume":"10","author":"Maity","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"2","key":"2026101404073675700_cit47","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1021\/acs.molpharmaceut.7b01119","article-title":"Engineered cellular uptake and controlled drug delivery using two dimensional nanoparticle and polymer for cancer treatment","volume":"15","author":"Senapati","year":"2018","journal-title":"Mol. Pharmaceutics"},{"issue":"1","key":"2026101404073675700_cit48","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13431-7","article-title":"Multifunctional green synthesized Cu\u2013Al layered double hydroxide (LDH) nanoparticles: anti-cancer and antibacterial activities","volume":"12","author":"Kiani","year":"2022","journal-title":"Sci. Rep."},{"key":"2026101404073675700_cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.clay.2022.106630","article-title":"Assembled Fe3O4 nanoparticles on ZnAl LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity","volume":"228","author":"Chai","year":"2022","journal-title":"Appl. Clay Sci."},{"issue":"44","key":"2026101404073675700_cit50","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202506499","article-title":"Doxorubicin Intercalated Co-Al Layered Double Hydroxide Nanocarrier With pH-Responsive Controlled Release and Selective Melanoma Suppression: Toward Next-Generation Nanotherapeutics","volume":"21","author":"Maity","year":"2025","journal-title":"Small"},{"key":"2026101404073675700_cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104829","article-title":"NiFe-layered double hydroxide nanoparticle for co-delivery of DOX and siRNA to overcome multidrug resistance in MCF-7\/ADR cells","volume":"87","author":"Bao","year":"2023","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"2026101404073675700_cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpta.2021.100171","article-title":"Dextrin and polyurethane graft copolymers as drug carrier: synthesis, characterization, drug release, biocompatibility and in-vitro toxicity","volume":"2","author":"Shukla","year":"2021","journal-title":"Carbohydr. Polym. Technol. Appl."},{"issue":"14","key":"2026101404073675700_cit53","doi-asserted-by":"publisher","first-page":"6126","DOI":"10.1039\/d2cs00236a","article-title":"Layered double hydroxide-based nanomaterials for biomedical applications","volume":"51","author":"Hu","year":"2022","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"2026101404073675700_cit54","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduction Targeted Ther."},{"issue":"19","key":"2026101404073675700_cit55","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202500738","article-title":"Mechanically Responsive Organic\u2013Inorganic Hybrid as Advanced Delivery Vehicle for Targeted Cancer Treatment","volume":"14","author":"Maity","year":"2025","journal-title":"Adv. Healthcare Mater."},{"issue":"2","key":"2026101404073675700_cit56","doi-asserted-by":"publisher","first-page":"75","DOI":"10.46439\/cancerbiology.3.043","article-title":"Injectable hydrogel of biopolymers as controlled drug-delivery vehicle for melanoma treatment: A commentary","volume":"3","author":"Maity","year":"2022","journal-title":"J. Cancer Biol."},{"issue":"18","key":"2026101404073675700_cit57","doi-asserted-by":"publisher","first-page":"4427","DOI":"10.1039\/d3tb02414h","article-title":"Injectable in situ gelling methylcellulose-based hydrogels for bone tissue regeneration","volume":"12","author":"Bonetti","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"2026101404073675700_cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2020.101324","article-title":"Methyl cellulose solutions and gels: Fibril formation and gelation properties","volume":"112","author":"Coughlin","year":"2021","journal-title":"Prog. Polym. Sci."},{"issue":"6","key":"2026101404073675700_cit59","doi-asserted-by":"publisher","DOI":"10.3390\/gels9060469","article-title":"Rheological considerations of pharmaceutical formulations: Focus on viscoelasticity","volume":"9","author":"Budai","year":"2023","journal-title":"Gels"},{"key":"2026101404073675700_cit60","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.colsurfb.2016.05.054","article-title":"In vivo pharmacokinetics, biodistribution and the anti-tumor effect of cyclic RGD-modified doxorubicin-loaded polymers in tumor-bearing mice","volume":"146","author":"Wang","year":"2016","journal-title":"Colloids Surf., B"},{"issue":"2","key":"2026101404073675700_cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100398","article-title":"Deep learning\u2013based H-score quantification of immunohistochemistry-stained images","volume":"37","author":"Wen","year":"2024","journal-title":"Mod. Pathol."},{"issue":"24","key":"2026101404073675700_cit62","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.3465","article-title":"Semi-quantitative determination of protein expression using immunohistochemistry staining and analysis: an integrated protocol","volume":"9","author":"Crowe","year":"2019","journal-title":"Bio-Protoc."},{"issue":"9","key":"2026101404073675700_cit63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245638","article-title":"Pixelwise H-score: a novel digital image analysis-based metric to quantify membrane biomarker expression from immunohistochemistry images","volume":"16","author":"Ram","year":"2021","journal-title":"PLoS One"},{"issue":"20","key":"2026101404073675700_cit64","doi-asserted-by":"publisher","first-page":"20135","DOI":"10.1021\/acsnano.3c05831","article-title":"Nanocrystals slow-releasing ropivacaine and doxorubicin to synergistically suppress tumor recurrence and relieve postoperative pain","volume":"17","author":"Peng","year":"2023","journal-title":"ACS Nano"},{"issue":"9","key":"2026101404073675700_cit65","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/s42256-023-00716-3","article-title":"CHGNet as a pretrained universal neural network potential for charge-informed atomistic modelling","volume":"5","author":"Deng","year":"2023","journal-title":"Nat. Mach. Intell."},{"issue":"22","key":"2026101404073675700_cit66","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210788","article-title":"Machine-learning-assisted determination of the global zero-temperature phase diagram of materials","volume":"35","author":"Schmidt","year":"2023","journal-title":"Adv. Mater."},{"issue":"1","key":"2026101404073675700_cit67","doi-asserted-by":"publisher","DOI":"10.1038\/s41524-025-01872-3","article-title":"MOFSimBench: evaluating universal machine learning interatomic potentials in metal-organic framework molecular modeling","volume":"12","author":"Kra\u00df","year":"2025","journal-title":"npj Comput. Mater."},{"key":"2026101404073675700_cit68","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4419-6351-2","volume-title":"Molecular modeling and simulation: an interdisciplinary guide","author":"Schlick","year":"2010"},{"issue":"14","key":"2026101404073675700_cit69","doi-asserted-by":"publisher","first-page":"4275","DOI":"10.1039\/d6tb00166a","article-title":"Design of a cholic acid-based triarmed star polymer network for targeted and sustained drug delivery for melanoma treatment","volume":"14","author":"Chowdhury","year":"2026","journal-title":"J. Mater. Chem. B"}],"container-title":["ACS Applied Materials &amp; Interfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsami.6c13200","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/doi\/10.1021\/acsami.6c13200\/68751085\/am-2026-13200w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/aamick\/article-pdf\/doi\/10.1021\/acsami.6c13200\/68751085\/am-2026-13200w.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:29:36Z","timestamp":1791966576000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/aamick\/article\/18\/40\/54547\/5444874\/Trimetallic-Cu-Zn-Fe-Layered-Double-Hydroxide"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":69,"journal-issue":{"issue":"40","published-online":{"date-parts":[[2026,10,5]]},"published-print":{"date-parts":[[2026,10,14]]}},"URL":"https:\/\/doi.org\/10.1021\/acsami.6c13200","relation":{},"ISSN":["1944-8244","1944-8252"],"issn-type":[{"value":"1944-8244","type":"print"},{"value":"1944-8252","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]}}}