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In this work, we utilized a DNA hairpin structure with tetramethylrhodamine at its 3\u2032 end to modify the surface of silicon nanowires (SiNWs) and obtained a SiNW-based thermometer. The thermometer exhibited high spatial resolution, excellent temperature response, favorable anti-interference capability and reversibility. Using the thermometer, we found a pronounced temperature increase in PC-12 cells upon H2O2 exposure and a more drastic thermal response of neurites to the stimulation compared to that of the soma, which may be related to the H2O2-induced opening of the mitochondrial permeability transition pore. This work not only provides a method to simultaneously detect the temperature changes of the soma and the neurites with high spatial resolution but also offers valuable perspectives for understanding the thermodynamic mechanisms implicated in neurodegenerative diseases.<\/jats:p>","DOI":"10.1021\/acsami.6c13330","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:02:05Z","timestamp":1791975725000},"source":"Crossref","is-referenced-by-count":0,"title":["DNA-Modified Nanowire Thermometer Uncovers Thermal Responses of Neuronal Soma and Neurites to H2O2 Treatment"],"prefix":"10.1021","author":[{"given":"Hongyuan","family":"Wang","sequence":"first","affiliation":[{"name":"Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100190"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100190"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Shen","sequence":"additional","affiliation":[{"name":"Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100190"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100190"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1017-5456","authenticated-orcid":true,"given":"Guangwei","family":"She","sequence":"additional","affiliation":[{"name":"Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100190"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6613-5368","authenticated-orcid":true,"given":"Lixuan","family":"Mu","sequence":"additional","affiliation":[{"name":"Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100190"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5747-4862","authenticated-orcid":true,"given":"Wensheng","family":"Shi","sequence":"additional","affiliation":[{"name":"Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100190"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"1","key":"2026101407015710400_cit1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12974-022-02446-6","article-title":"The Role of Th17 Cells\/IL-17A in AD, PD, ALS and the Strategic Therapy Targeting on IL-17A","volume":"19","author":"Fu","year":"2022","journal-title":"J. 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