{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T08:39:52Z","timestamp":1792744792965,"version":"4.5.0"},"reference-count":70,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008211","name":"Drexel University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006792","name":"Hartwell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Congenital heart defects (CHDs), particularly single-ventricle anomalies such as hypoplastic left heart syndrome (HLHS), require early surgical intervention using fixed-diameter vascular shunts. However, current shunts are incapable of adapting to the physiological changes of infant growth, often leading to hemodynamic imbalance and elevated mortality risk. Here, we report a geometrically tunable cardiovascular shunt lined with a photoresponsive hydrogel based on methacrylated dextran (DexMA) and dithiothreitol (DTT). This dual-stage crosslinked hydrogel system enables minimally invasive modulation of the inner lumen diameter in response to external blue light. We optimized the hydrogel composition to achieve both mechanical robustness (Young\u2019s modulus \u2248 8.5 kPa) and light-induced deswelling, allowing for lumen expansion up to 39% with high stability over one month. In vitro studies confirmed excellent cytocompatibility, hemocompatibility, and minimal immune activation. Prototype annular shunts demonstrated precise, programmable diameter increases (15\u201318%) corresponding to computational models of infant growth. This dynamic, photoresponsive platform is a critical advance toward implantable materials for personalized cardiovascular interventions and a significant step toward growth-accommodating pediatric medical devices.<\/jats:p>","DOI":"10.1021\/acsami.6c13452","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:01:47Z","timestamp":1792720907000},"source":"Crossref","is-referenced-by-count":0,"title":["A Geometrically Tunable Cardiovascular Shunt for the Individualized Care of Neonates with Congenital Heart Defects"],"prefix":"10.1021","author":[{"given":"Akari J.","family":"Seiner","sequence":"first","affiliation":[{"name":"Drexel University , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Posthill","sequence":"additional","affiliation":[{"name":"Drexel University , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Hager","sequence":"additional","affiliation":[{"name":"Drexel University , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Gontarski","sequence":"additional","affiliation":[{"name":"Drexel University , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco E.","family":"Zamora","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolann L.","family":"Espy","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9298-2392","authenticated-orcid":true,"given":"Biplab","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Drexel University , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob S.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7798-1490","authenticated-orcid":true,"given":"Kara L.","family":"Spiller","sequence":"additional","affiliation":[{"name":"Drexel University , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Throckmorton","sequence":"additional","affiliation":[{"name":"Drexel University , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2168-0802","authenticated-orcid":true,"given":"Christopher B.","family":"Rodell","sequence":"additional","affiliation":[{"name":"Drexel University , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"issue":"8","key":"2026102222014348900_cit1","doi-asserted-by":"publisher","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"issue":"2","key":"2026102222014348900_cit2","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1093\/ije\/dyz009","article-title":"Global birth prevalence of congenital heart defects 1970-2017: updated systematic review and meta-analysis of 260 studies","volume":"48","author":"Liu","year":"2019","journal-title":"Int. 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