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As an essential trace element, zinc plays a crucial role in maintaining intestinal homeostasis and mitigating UC progression. However, conventional zinc oxide (ZnO) suffers from low bioavailability; excessive unabsorbed zinc leads to environmental pollution, and long-term overuse can induce bacterial resistance. To address these critical drawbacks, a microcrystalline cellulose-supported ZnO quantum dots (MCC@ZnO QDs) composite was synthesized via a sol\u2212gel method, where ZnO quantum dots were immobilized onto microcrystalline cellulose (MCC) matrices. The antibacterial activity and protective efficacy of the composite against dextran sulfate sodium (DSS)-induced colitis were systematically evaluated. Despite a ZnO loading of approximately 78.77 wt %, the MCC@ZnO QDs composite exhibited therapeutic effects comparable to those of pure ZnO QDs, including alleviating weight loss, restoring colon length, repairing intestinal barrier integrity, regulating inflammatory cytokine expression, enhancing antioxidant capacity, and remodeling the gut microbiota. This composite enhances zinc bioavailability, thereby achieving dose reduction with improved efficacy and providing a green, efficient strategy for the intervention of UC.<\/jats:p>","DOI":"10.1021\/acsami.6c13980","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T09:01:47Z","timestamp":1786957307000},"page":"45119-45131","source":"Crossref","is-referenced-by-count":0,"title":["Fabrication of Microcrystalline Cellulose\/ZnO Quantum Dots with Enhanced Zinc Bioavailability for Alleviating DSS-Induced Ulcerative Colitis in Mice"],"prefix":"10.1021","volume":"18","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[{"name":"Sichuan Agricultural University , , , ,","place":["Chengdu, Sichuan, China, 611130"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7784-6418","authenticated-orcid":true,"given":"Wei","family":"Fan","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University , , , ,","place":["Chengdu, Sichuan, China, 611130"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuang","family":"Chen","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University , , , ,","place":["Chengdu, Sichuan, China, 611130"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wu","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University , , , ,","place":["Chengdu, Sichuan, China, 611130"]},{"name":"Sichuan Chelota Biotechnology Group Co., Ltd. , , ,","place":["Chengdu, Sichuan, China, 618302"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Chen","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University , , , ,","place":["Chengdu, Sichuan, China, 611130"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Wu","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University , , ,","place":["Chengdu, China, 611130"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6234-2231","authenticated-orcid":true,"given":"Xianxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Sichuan Agricultural University , , , ,","place":["Chengdu, Sichuan, China, 611130"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"2026090101431434900_cit1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2024.11.023","article-title":"Current advances in nanozyme-based nanodynamic therapies for cancer","volume":"191","author":"Zhou","year":"2025","journal-title":"Acta Biomater."},{"key":"2026090101431434900_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102441","article-title":"Mo3Se4 nanoparticle with ROS scavenging and multi-enzyme activity for the treatment of DSS-induced colitis in mice","author":"Guo","year":"2022","journal-title":"Redox Biology."},{"issue":"7422","key":"2026090101431434900_cit3","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"Jostins","year":"2012","journal-title":"Nature"},{"issue":"1","key":"2026090101431434900_cit4","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"issue":"10080","key":"2026090101431434900_cit5","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"issue":"4","key":"2026090101431434900_cit6","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites as key actors in inflammatory bowel disease","volume":"17","author":"Lavelle","year":"2020","journal-title":"Nat. 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