{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:35:31Z","timestamp":1793072131024,"version":"4.5.0"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["787073"],"award-info":[{"award-number":["787073"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The large internal surface areas and porosities of metal\u2013organic frameworks (MOFs) promise a wide variety of applications in gas capture, storage, and delivery. To realize their potential, MOFs need to be processed into suitable forms for the target function. Here, we demonstrate the preparation and functional assessment of extruded MOF\u2013polymer composite tubing comprising 1 and 5 wt % Zn-MOF-74 incorporated into a medical-grade polyamide\/polyether block copolymer for the delivery of the biological signaling molecule, nitric oxide (NO). Solutions to the challenges associated with water evolution during extrusion, which can severely affect the composite properties, are presented. We employ X-ray computed tomography to provide evidence for uniform dispersion of the MOF within the tubing, and we show that the mechanical properties of the polymer tubing are not negatively impacted by MOF incorporation. We demonstrate using in\u00a0vitro experiments that the gas-loaded tubing is non-toxic and that the MOF\u2013polymer composite delivers NO at amounts relevant for the prevention of three of the most common complications in different types of catheterizations: arterial vasospasm, catheter-related thrombosis, and microbial infection.<\/jats:p>","DOI":"10.1021\/acsami.6c14023","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:01:46Z","timestamp":1791450106000},"page":"56606-56621","source":"Crossref","is-referenced-by-count":0,"title":["Gas Delivery from Extruded MOF\u2013Polymer Composites for Mitigation of Complications Associated with Catheters Used in Interventional Cardiology"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9485-2543","authenticated-orcid":true,"given":"Morven J.","family":"Duncan","sequence":"first","affiliation":[{"name":"University of St Andrews , , North Haugh , , ,","place":["St Andrews, Fife, U.K., KY16 9ST"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart J.","family":"Warrender","sequence":"additional","affiliation":[{"name":"University of St Andrews , , North Haugh , , ,","place":["St Andrews, Fife, U.K., KY16 9ST"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronagh","family":"Millar","sequence":"additional","affiliation":[{"name":"Queen\u2019s University Belfast , , Global Point Avenue , ,","place":["Newtownabbey, U.K., BT36 5TB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Douglas","sequence":"additional","affiliation":[{"name":"Queen\u2019s University Belfast , , Global Point Avenue , ,","place":["Newtownabbey, U.K., BT36 5TB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham S.","family":"Garrett","sequence":"additional","affiliation":[{"name":"Queen\u2019s University Belfast , , Global Point Avenue , ,","place":["Newtownabbey, U.K., BT36 5TB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan H.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Queen\u2019s University Belfast , , Global Point Avenue , ,","place":["Newtownabbey, U.K., BT36 5TB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Menary","sequence":"additional","affiliation":[{"name":"Queen\u2019s University Belfast , , Global Point Avenue , ,","place":["Newtownabbey, U.K., BT36 5TB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma M.","family":"Coghill","sequence":"additional","affiliation":[{"name":"University of the Highlands and Islands , , ,","place":["Inverness, U.K., IV2 5NA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Treweeke","sequence":"additional","affiliation":[{"name":"University of the Highlands and Islands , , ,","place":["Inverness, U.K., IV2 5NA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Rutter","sequence":"additional","affiliation":[{"name":"University of the Highlands and Islands , , ,","place":["Inverness, U.K., IV2 5NA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Amores","family":"Morillo","sequence":"additional","affiliation":[{"name":"5D Health Protection Group , Accelerator Building, 1 Daulby Street , ,","place":["Liverpool, U.K., L7 8XZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus J.","family":"Swann","sequence":"additional","affiliation":[{"name":"5D Health Protection Group , Accelerator Building, 1 Daulby Street , ,","place":["Liverpool, U.K., L7 8XZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus J.","family":"Watson","sequence":"additional","affiliation":[{"name":"5D Health Protection Group , Accelerator Building, 1 Daulby Street , ,","place":["Liverpool, U.K., L7 8XZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Percival","sequence":"additional","affiliation":[{"name":"5D Health Protection Group , Accelerator Building, 1 Daulby Street , ,","place":["Liverpool, U.K., L7 8XZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Alvarez-Borges","sequence":"additional","affiliation":[{"name":"University of Southampton , , ,","place":["Southampton, U.K., SO17 1BJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn E.","family":"Rankin","sequence":"additional","affiliation":[{"name":"University of Southampton , , ,","place":["Southampton, U.K., SO17 1BJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Leslie","sequence":"additional","affiliation":[{"name":"Raigmore Hospital , , Old Perth Road , ,","place":["Inverness, U.K., IV2 3UJ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian L.","family":"Megson","sequence":"additional","affiliation":[{"name":"University of St Andrews , , North Haugh , , ,","place":["St Andrews, Fife, U.K., KY16 9ST"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7809-0315","authenticated-orcid":true,"given":"Russell E.","family":"Morris","sequence":"additional","affiliation":[{"name":"University of St Andrews , , North Haugh , , ,","place":["St Andrews, Fife, U.K., KY16 9ST"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"issue":"6","key":"2026102108071345700_cit1","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1002\/pi.5315","article-title":"Application of Metal - Organic Frameworks","volume":"66","author":"Pettinari","year":"2017","journal-title":"Polym. 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