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In this study, a porphyrin-based COF with abundant amino groups has been synthesized through a defect engineering strategy, which further reacts with hyaluronic acid (HA) through an amide condensation reaction to obtain a COF-HA hydrogel. The hybrid hydrogel retains the photochemical properties of porphyrin-based COFs and is also endowed with the advantages of hydrogels, including good adhesion, plasticity, and biocompatibility. The hybrid material exhibits excellent photothermal conversion performance, achieving a temperature elevation of 29 \u00b0C under 808 nm laser irradiation (2 W\/cm2) within 5 min. Additionally, the composite achieves complete antibacterial efficacy against Staphylococcus aureus and Escherichia coli under 10 min of the NIR irradiation. Furthermore, as a wound dressing, the composite hydrogel can effectively alleviate inflammatory response in S. aureus-infected cutaneous wounds, thereby contributing to prominent acceleration of wound healing and skin regeneration. This work broadens the translational prospects of porphyrin-functionalized COFs for antibacterial treatment and wound repair applications.<\/jats:p>","DOI":"10.1021\/acsami.6c14145","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:01:52Z","timestamp":1790164912000},"page":"53238-53250","source":"Crossref","is-referenced-by-count":0,"title":["Porphyrin-Based Covalent Organic Framework Hydrogel Integrated with Hyaluronic Acid for Photothermal Antibacterial Wound Healing"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3733-7913","authenticated-orcid":true,"given":"Nan","family":"Dai","sequence":"first","affiliation":[{"name":"Hefei Normal University, Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration , , , ,","place":["Hefei, Anhui, China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyu","family":"Ding","sequence":"additional","affiliation":[{"name":"Hefei Normal University, Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration , , , ,","place":["Hefei, Anhui, China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Hefei Normal University, Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration , , , ,","place":["Hefei, Anhui, China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Ma","sequence":"additional","affiliation":[{"name":"Hefei Normal University, Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration , , , ,","place":["Hefei, Anhui, China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hefei Normal University, Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration , , , ,","place":["Hefei, Anhui, China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hefei Normal University, Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration , , , ,","place":["Hefei, Anhui, China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Kang","sequence":"additional","affiliation":[{"name":"Hefei Normal University, Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration , , , ,","place":["Hefei, Anhui, China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Hefei Normal University, Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration , , , ,","place":["Hefei, Anhui, China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmiao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hefei Normal University, Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration , , , ,","place":["Hefei, Anhui, China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2906-0125","authenticated-orcid":true,"given":"Bin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Hefei Normal University, Anhui Engineering Laboratory for Medicinal and Food Homologous Natural Resources Exploration , , , ,","place":["Hefei, Anhui, China, 230601"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"2026100711084406500_cit1","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41579-022-00820-y","article-title":"Molecular mechanisms of antibiotic resistance revisited","volume":"21","author":"Darby","year":"2023","journal-title":"Nat. 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