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However, it is still challenging to develop effective organic sonosensitizers with good stability for imaging and SDT. In this work, in order to reveal the structure\u2013activity relationship of sonosensitizers, we designed and synthesized a series of aza-BODIPY derivatives (AB1\u2013AB5) with different substituents (methoxy, octyloxy, anthracene, and iodine atom) to systematically evaluate the influence of electron-donating effect and heavy atom effect on the sonodynamic efficacy. Among them, the iodine-substituted aza-BODIPY (AB5) demonstrated superior sonodynamic performance and exhibited enhanced reactive oxygen species (ROS) generation. Subsequently, we encapsulated AB5 with the hydrophilic polymer DSPE-mPEG2000 to create nanoparticles referred to as iodinated aza-BODIPY nanoparticles (IABNPs). In vitro cellular assays and in vivo animal experiments showed that IABNPs had excellent stability, biocompatibility, and pronounced sonodynamic effect, which resulted in significant inhibition of tumor growth. Moreover, the fluorescent emission characteristics of AB5 enabled fluorescence-guided imaging and real-time monitoring during tumor treatment. This study systematically explored the influence of substituents on the sonodynamic effect of aza-BODIPY, providing important theoretical foundations and perspectives for future research in related fields.<\/jats:p>","DOI":"10.1021\/acsami.6c14426","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T23:01:34Z","timestamp":1789858894000},"page":"52142-52153","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Aza-BODIPY Derivatives as Sonosensitizers for Deep-Tissue Sonotheranostics in Breast Cancer"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8936-2945","authenticated-orcid":true,"given":"Xiaofeng","family":"He","sequence":"first","affiliation":[{"name":"Cancer Hospital of Shantou University Medical College , , ,","place":["Shantou, China, 515000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shantou Clinical Medical College of Jinan University (Shantou Central Hospital), Jinan University , , ,","place":["Shantou, China, 515031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiatian","family":"Song","sequence":"additional","affiliation":[{"name":"Cancer Hospital of Shantou University Medical College , , ,","place":["Shantou, China, 515000"]},{"name":"Shantou University Medical College , ,","place":["Shantou, China, 515041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Li","sequence":"additional","affiliation":[{"name":"Shantou Clinical Medical College of Jinan University (Shantou Central Hospital), Jinan University , , ,","place":["Shantou, China, 515031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Wang","sequence":"additional","affiliation":[{"name":"Shantou Clinical Medical College of Jinan University (Shantou Central Hospital), Jinan University , , ,","place":["Shantou, China, 515031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixiu","family":"Yao","sequence":"additional","affiliation":[{"name":"Shantou Central Hospital , , ,","place":["Shantou, China, 515031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Hospital of Shantou University Medical College , , ,","place":["Shantou, China, 515000"]},{"name":"Shantou University Medical College , ,","place":["Shantou, China, 515041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Wu","sequence":"additional","affiliation":[{"name":"Shantou Clinical Medical College of Jinan University (Shantou Central Hospital), Jinan University , , ,","place":["Shantou, China, 515031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6825-0995","authenticated-orcid":true,"given":"Yunjian","family":"Xu","sequence":"additional","affiliation":[{"name":"Shandong First Medical University & Shandong Academy of Medical Sciences , , ,","place":["Taian, China, 271016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Zhai","sequence":"additional","affiliation":[{"name":"Cancer Hospital of Shantou University Medical College , , ,","place":["Shantou, China, 515000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8870-0639","authenticated-orcid":true,"given":"Siqi","family":"Qiu","sequence":"additional","affiliation":[{"name":"Shantou Clinical Medical College of Jinan University (Shantou Central Hospital), Jinan University , , ,","place":["Shantou, China, 515031"]},{"name":"Shantou Clinical Medical College of Jinan University (Shantou Central Hospital), Jinan University , , ,","place":["Shantou, China, 515031"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"issue":"3","key":"2026093001080112000_cit1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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