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Here, we present a magnetically driven hydrogel\u2013elastomer composite consisting of an auxetic-like inward-concave chamfered hard-magnetic soft actuator and a central GelMA matrix. Under a parallel magnetic field, the actuator undergoes in-plane expansion, transferring an approximately 10% near-equibiaxial strain to the hydrogel. Benzophenone-mediated interface modification enhances hydrogel\u2013elastomer adhesion and improves interfacial strain-transfer capability. Finite-element-guided geometric optimization identifies a 3 mm inward-concave chamfered design that balances corner constraint reduction and auxetic-like deformation coupling. In a proof-of-concept cell-culture demonstration, RAW264.7 macrophages cultured on the platform exhibited heterogeneous morphological changes and F-actin reorganization during cyclic near-equibiaxial stimulation, supporting the feasibility of the platform for controlled cellular mechanical stimulation. This composite provides a magnetically programmable platform for soft-material deformation and mechanobiological applications.<\/jats:p>","DOI":"10.1021\/acsami.6c14947","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:02:26Z","timestamp":1792018946000},"source":"Crossref","is-referenced-by-count":0,"title":["Magnetically Programmable Hydrogel\u2013Elastomer Composite for Engineering Controlled Equibiaxial Mechanical Microenvironments"],"prefix":"10.1021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-5331","authenticated-orcid":true,"given":"Wei","family":"Gao","sequence":"first","affiliation":[{"name":"Lanzhou University of Technology , , ,","place":["Lanzhou, China, 730050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Mai","sequence":"additional","affiliation":[{"name":"Lanzhou University of Technology , , ,","place":["Lanzhou, China, 730050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Gao","sequence":"additional","affiliation":[{"name":"Lanzhou University of Technology , , ,","place":["Lanzhou, China, 730050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2968-6280","authenticated-orcid":true,"given":"Wenheng","family":"Han","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0537-4656","authenticated-orcid":true,"given":"Xingzhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"4","key":"2026101419021922500_cit1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/nrm1890","article-title":"Local force and geometry sensing regulate cell functions","volume":"7","author":"Vogel","year":"2006","journal-title":"Nat. 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