{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:51:13Z","timestamp":1792090273519,"version":"4.4.0"},"reference-count":25,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100017531","name":"Medical and Health Research Project of Zhejiang Province","doi-asserted-by":"publisher","award":["WKJ-ZJ-26049"],"award-info":[{"award-number":["WKJ-ZJ-26049"]}],"id":[{"id":"10.13039\/501100017531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008867","name":"Department of Education of Zhejiang Province","doi-asserted-by":"publisher","award":["Y202455352"],"award-info":[{"award-number":["Y202455352"]}],"id":[{"id":"10.13039\/501100008867","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["ZCLKLY26H0201"],"award-info":[{"award-number":["ZCLKLY26H0201"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although expanded polytetrafluoroethylene (ePTFE) endografts provide excellent mechanical exclusion of aneurysm blood flow, they remain biologically inert and lack surface functions that actively prevent bacterial colonization or promote favorable graft\u2013vessel interface responses following implantation. Here, we report a dual-functional hydrogel coating for ePTFE vascular grafts that integrates antibacterial protection with localized procoagulant activity at the graft\u2013vessel interface. The coating, denoted as ZnO@CH, is prepared via in situ photopolymerization of methacryloyl-modified chitosan (CSMA) incorporating zinc oxide (ZnO) nanoparticles, forming a stable, spatially confined functional layer on the outer surface of ePTFE grafts. In vitro and in vivo evaluations demonstrate that the coating exhibits potent broad-spectrum antibacterial activity against Escherichia coli and methicillin-resistant Staphylococcus aureus while maintaining cytocompatibility with vascular endothelial cells. The ZnO@CH hydrogel promoted localized thrombus formation in a rat abdominal aorta model. Separately, an in vitro liquid-barrier assay showed that hydrogel-coated ePTFE retained its barrier function under the tested conditions. Systemic safety assessments in rodent models reveal no significant acute or chronic toxicity. Collectively, this dual-functional coating strategy offers a promising biomaterial approach for improving the biological performance of ePTFE vascular grafts.<\/jats:p>","DOI":"10.1021\/acsami.6c15053","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:01:24Z","timestamp":1792087284000},"source":"Crossref","is-referenced-by-count":0,"title":["A Dual-Functional Hydrogel Coating for Expanded Polytetrafluoroethylene Endografts with Antibacterial and Interface-Sealing Functions"],"prefix":"10.1021","author":[{"given":"Yanbo","family":"Lou","sequence":"first","affiliation":[{"name":"Center for Regenerative and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine, International Institutes of Medicine, International School of Medicine, Zhejiang University , , ,","place":["Yiwu, China, 322000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Chen","sequence":"additional","affiliation":[{"name":"Hangzhou City University , ,","place":["Hangzhou, China, 310000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchao","family":"Sun","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University , , ,","place":["Yiwu, China, 322000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Jia","sequence":"additional","affiliation":[{"name":"Center for Regenerative and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine, International Institutes of Medicine, International School of Medicine, Zhejiang University , , ,","place":["Yiwu, China, 322000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhao","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine , ,","place":["Hangzhou, China, 310000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjin","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Regenerative and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine, International Institutes of Medicine, International School of Medicine, Zhejiang University , , ,","place":["Yiwu, China, 322000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyou","family":"Ding","sequence":"additional","affiliation":[{"name":"Center for Regenerative and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine, International Institutes of Medicine, International School of Medicine, Zhejiang University , , ,","place":["Yiwu, China, 322000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunxian","family":"Ji","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University , , ,","place":["Yiwu, China, 322000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Regenerative and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine, International Institutes of Medicine, International School of Medicine, Zhejiang University , , ,","place":["Yiwu, China, 322000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziheng","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Zhejiang University School of Medicine , , ,","place":["Hangzhou, China, 310000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihao","family":"Pan","sequence":"additional","affiliation":[{"name":"Liangzhu Laboratory, Zhejiang University School of Medicine , ,","place":["Hangzhou, China, 310000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkun","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Zhejiang University School of Medicine , , ,","place":["Hangzhou, China, 310000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2234-4459","authenticated-orcid":true,"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Center for Regenerative and Aging Medicine, The Fourth Affiliated Hospital of School of Medicine, International Institutes of Medicine, International School of Medicine, Zhejiang University , , ,","place":["Yiwu, China, 322000"]},{"name":"Zhejiang Key Laboratory of Precision Diagnosis and Treatment for Lung Cancer , ,","place":["Yiwu, China, 322000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"5","key":"2026101514011594900_cit1","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41569-020-00472-6","article-title":"Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes","volume":"18","author":"Bossone","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"2026101514011594900_cit2","doi-asserted-by":"publisher","first-page":"3538","DOI":"10.1093\/eurheartj\/ehae179","article-title":"ESC Guidelines for the management of peripheral arterial and aortic diseases","volume":"36","author":"Mazzolai","year":"2024","journal-title":"Eur. Heart J."},{"issue":"24","key":"2026101514011594900_cit3","doi-asserted-by":"publisher","first-page":"35080","DOI":"10.1021\/acsami.5c03008","article-title":"Precision Drug Delivery for Multifunctional Treatment of Abdominal Aortic Aneurysm Using Bioactive Tea Polyphenol Nanoparticles","volume":"17","author":"Xu","year":"2025","journal-title":"ACS Appl. Mater. 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