{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:45:18Z","timestamp":1792514718763,"version":"4.5.0"},"reference-count":91,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Highly porous hydrogel scaffolds are critical for advancing three-dimensional printing in tissue engineering. Interconnected porous networks facilitate nutrient diffusion, waste removal, and cell infiltration, necessary processes for tissue regeneration. Emulgel-based inks are developed using oil-in-water Pickering emulsions, in which mineral oil serves as a sacrificial porogen within a carboxymethyl cellulose (CMC)\/Laponite matrix, with Laponite providing stabilization of the emulsion. Nine formulations are prepared by varying CMC (0.5\u20131.0 wt %) and mineral oil (10\u201320 wt %) concentrations at fixed Laponite (2 wt %). Rheological characterization confirms pronounced shear thinning, appropriate viscoelasticity, and rapid thixotropic recovery, establishing suitability for extrusion-based printing. Post-printing lyophilization and oil removal produce interconnected, homogeneous pore networks, as revealed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Hydrated scaffolds exhibit compressive moduli of 20\u201330 kPa, overlapping with native soft tissue stiffness. Swelling and degradation analyses confirm structural stability under physiological conditions. Biological assessment using human dental pulp mesenchymal stromal cells (DPMSCs) identifies the 1.0 wt % CMC, Laponite, and 10 wt % oil formulation as optimal, supporting sustained cell proliferation over 28 days following lyophilization and pre-conditioning. This platform provides fabrication advances in 3D-printed hydrogel scaffolds, enhanced porosity, and mechanical properties for soft-tissue engineering and drug delivery applications.<\/jats:p>","DOI":"10.1021\/acsami.6c15127","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:07:12Z","timestamp":1792008432000},"source":"Crossref","is-referenced-by-count":0,"title":["Engineering Emulgel-Based Inks for 3D Printing Scaffolds with Enhanced Porosity for Supporting Cell Proliferation"],"prefix":"10.1021","author":[{"given":"Ingri Julieth","family":"Mancilla Corzo","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas (UNICAMP) , , , ,","place":["Campinas, S\u00e3o Paulo, Brazil, 13083-860"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Heline Lopes","family":"da Fons\u00eaca","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas (UNICAMP) , , , ,","place":["Campinas, S\u00e3o Paulo, Brazil, 13083-860"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc\u00edlia Val\u00e9ria","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Center for Information Technology Renato Archer (CTI) , , , ,","place":["Campinas, S\u00e3o Paulo, Brazil, 13069-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9763-2095","authenticated-orcid":true,"given":"Rodolpho Fagundes","family":"Correa","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas (UNICAMP) , , , ,","place":["Campinas, S\u00e3o Paulo, Brazil, 13083-852"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7062-9969","authenticated-orcid":true,"given":"Leticia Alves Martins de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas (UNICAMP) , , , ,","place":["Campinas, S\u00e3o Paulo, Brazil, 13083-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Ferman","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas (UNICAMP) , , , ,","place":["Campinas, S\u00e3o Paulo, Brazil, 13083-852"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5813-332X","authenticated-orcid":true,"given":"\u00c2ngela Maria","family":"Moraes","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas (UNICAMP) , , , ,","place":["Campinas, S\u00e3o Paulo, Brazil, 13083-852"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"D\u00e1vila","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas (UNICAMP) , , , ,","place":["Campinas, S\u00e3o Paulo, Brazil, 13083-860"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4224-4575","authenticated-orcid":true,"given":"Alexandre Leite Rodrigues de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas (UNICAMP) , , , ,","place":["Campinas, S\u00e3o Paulo, Brazil, 13083-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1981-9692","authenticated-orcid":true,"given":"Marcos Akira","family":"d'\u00c1vila","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas (UNICAMP) , , , ,","place":["Campinas, S\u00e3o Paulo, Brazil, 13083-860"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"issue":"8","key":"2026102012061542900_cit1","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/nbt.2958","article-title":"3D Bioprinting of Tissues and Organs","volume":"32","author":"Murphy","year":"2014","journal-title":"Nat. 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