{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:58:30Z","timestamp":1790758710635,"version":"4.1.0"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M723661"],"award-info":[{"award-number":["2022M723661"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["202206010087"],"award-info":[{"award-number":["202206010087"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["19ykzd39"],"award-info":[{"award-number":["19ykzd39"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572443"],"award-info":[{"award-number":["82572443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012541"],"award-info":[{"award-number":["2022A1515012541"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011932"],"award-info":[{"award-number":["2024A1515011932"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515010007"],"award-info":[{"award-number":["2025A1515010007"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Targeted degradation of extracellular and membrane-bound proteins holds immense therapeutic potential but remains technically challenging. Lysosome-targeting chimeras (LYTACs) have emerged to bridge this gap, yet platforms built on monomeric aptamers suffer from inadequate stability, inefficient cellular uptake, and a lack of modularity. Here, we developed a tetrahedral DNA nanostructure-based multivalent lysosome-targeting antibody platform (TDN-MLYTAB) to overcome these limitations. Our platform employs two key engineered components: a rigid TDN scaffold enables the precise multivalent display of aptamers to enhance binding stability and lysosomal targeting while preventing steric hindrance, and an engineered secondary antibody serves as a universal adaptor, conferring plug-and-play modularity. By simply exchanging the primary antibody, we achieved efficient degradation of multiple distinct cell-surface proteins in different cellular models without platform re-engineering. Compared to conventional flexible and monovalent systems, TDN-MLYTAB uniquely avoids structural collapse, exhibiting substantially improved internalization and a remarkable degradation efficiency of \u223c71% at 100 nM after 24 h. This work not only presents a versatile degradation platform but also demonstrates how programmable DNA nanostructures can overcome persistent bioconjugation challenges, advancing modular therapeutics toward application.<\/jats:p>","DOI":"10.1021\/acsami.6c15457","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:03:37Z","timestamp":1790021017000},"page":"52180-52189","source":"Crossref","is-referenced-by-count":0,"title":["Modular Lysosome-Targeting Platform Based on a Multivalent DNA Framework for Programmable Protein Degradation"],"prefix":"10.1021","volume":"18","author":[{"given":"Xin","family":"Wan","sequence":"first","affiliation":[{"name":"Sun Yat-Sen University , , , ,","place":["Guangzhou, Guangdong, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanhao","family":"Dou","sequence":"additional","affiliation":[{"name":"South China Normal University , , , ,","place":["Guangzhou, Guangdong, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , , ,","place":["Guangzhou, Guangdong, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , , ,","place":["Guangzhou, Guangdong, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Mao","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , , ,","place":["Guangzhou, Guangdong, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8761-5328","authenticated-orcid":true,"given":"Yuanqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sun Yat-Sen University , , , ,","place":["Guangzhou, Guangdong, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"2026093001065527600_cit1","doi-asserted-by":"publisher","first-page":"8337","DOI":"10.7150\/thno.62686","article-title":"Emerging protein degradation strategies: expanding the scope to extracellular and membrane proteins","volume":"11","author":"Lin","year":"2021","journal-title":"Theranostics"},{"key":"2026093001065527600_cit2","doi-asserted-by":"publisher","first-page":"4641","DOI":"10.1158\/0008-5472.CAN-21-1109","article-title":"Mechanisms of Therapeutic Antitumor Monoclonal Antibodies","volume":"81","author":"Tsao","year":"2021","journal-title":"Cancer Res."},{"key":"2026093001065527600_cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115911","article-title":"Recent progress in degradation of membrane proteins by PROTACs and alternative targeted protein degradation techniques","volume":"262","author":"Chen","year":"2023","journal-title":"Eur. 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