{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:37:35Z","timestamp":1793176655131,"version":"4.5.0"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"42","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100008996","name":"Capital Normal University","doi-asserted-by":"publisher","award":["2026JCZD01"],"award-info":[{"award-number":["2026JCZD01"]}],"id":[{"id":"10.13039\/100008996","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Municipal Natural Science Foundation","award":["JQ25020"],"award-info":[{"award-number":["JQ25020"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["22374103"],"award-info":[{"award-number":["22374103"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["32472618"],"award-info":[{"award-number":["32472618"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chemical signals in living plants are spatially confined, rapidly consumed, and strongly dependent on the delivery history of exogenous regulators, creating a need for bioelectronic interfaces that can interrogate molecular dynamics directly within intact tissues. Here, we integrate a nitric oxide (NO) nanoprodrug with a conductive hydrogel microneedle platform to connect controlled molecular delivery, in planta electrochemical readout, and downstream biological responses in living maize. The working electrode comprises a poly(vinyl alcohol)\/aramid nanofiber (PVA\/ANF) hydrogel containing FeMo-N\/C and an MXene conductive network. The hydrated microneedle architecture provides tissue-conformal contact and analyte transport, FeMo-N\/C enhances the NO-associated electrochemical response, and MXene improves interfacial charge transfer. The resulting platform responds to NO from 1 nM to 100 \u03bcM with a detection limit of 0.3 nM and discriminates NO from representative electroactive plant interferents. Chitosan nanoparticles containing S-nitroso-mercaptosuccinic acid were used to moderate NO release, and the microneedle interface resolved treatment-dependent leaf signals over 7 days under salt stress. Signal attenuation by the NO scavenger cPTIO supported the NO-related origin of the electrochemical response. The time-resolved readout was accompanied by improved growth, reduced lipid peroxidation, changes in osmotic and antioxidant responses, and altered expression of stress-responsive genes. This delivery\u2013bioelectronics\u2013analysis framework provides a materials-based strategy for evaluating reactive nanoprodrugs and interrogating transient chemical signaling in living plants.<\/jats:p>","DOI":"10.1021\/acsami.6c16130","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:01:20Z","timestamp":1792494080000},"page":"57254-57263","source":"Crossref","is-referenced-by-count":0,"title":["Hydrogel Microneedle-Enabled\n                    <i>In Situ<\/i>\n                    Monitoring of Leaf Nitric Oxide for Evaluating NO Nanoprodrug-Mediated Salt Stress Alleviation in Maize"],"prefix":"10.1021","volume":"18","author":[{"given":"Yuying","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Plant Protection, Chinese Academy of Agricultural Sciences , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"Wulan","sequence":"additional","affiliation":[{"name":"Capital Normal University , , ,","place":["Beijing, China, 100048"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9820-7218","authenticated-orcid":true,"given":"Qiliang","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Plant Protection, Chinese Academy of Agricultural Sciences , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4366-3114","authenticated-orcid":true,"given":"Pengyue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Plant Protection, Chinese Academy of Agricultural Sciences , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Plant Protection, Chinese Academy of Agricultural Sciences , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1501-5005","authenticated-orcid":true,"given":"Yuqing","family":"Lin","sequence":"additional","affiliation":[{"name":"Capital Normal University , , ,","place":["Beijing, China, 100048"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7217-7102","authenticated-orcid":true,"given":"Lidong","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Plant Protection, Chinese Academy of Agricultural Sciences , , ,","place":["Beijing, China, 100193"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"2026102802074387900_cit1","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1146\/annurev.arplant.59.032607.092911","article-title":"Mechanisms of Salinity Tolerance","volume":"59","author":"Munns","year":"2008","journal-title":"Annu. 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Sci."},{"issue":"2","key":"2026102802074387900_cit5","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.cell.2016.08.029","article-title":"Abiotic Stress Signaling and Responses in Plants","volume":"167","author":"Zhu","year":"2016","journal-title":"Cell"},{"key":"2026102802074387900_cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.165832","article-title":"A Review of Plants Strategies to Resist Biotic and Abiotic Environmental Stressors","volume":"900","author":"Nawaz","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"10","key":"2026102802074387900_cit7","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/s41580-022-00479-6","article-title":"Plant Hormone Regulation of Abiotic Stress Responses","volume":"23","author":"Waadt","year":"2022","journal-title":"Nat. Rev. Mol. 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J."},{"issue":"19","key":"2026102802074387900_cit50","doi-asserted-by":"publisher","DOI":"10.3390\/s24196197","article-title":"A Highly Sensitive, Low Creep Hydrogel Sensor for Plant Growth Monitoring","volume":"24","author":"Xu","year":"2024","journal-title":"Sensors"},{"issue":"28","key":"2026102802074387900_cit51","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1149\/MA2019-01\/28\/1364","article-title":"Multi-Responsive Hydrogel Based Flexible Sensors for Plants\/Animals Metabolic Stress Analytics","volume":"235","author":"Mugo","year":"2019","journal-title":"Meet. Abstr."},{"issue":"23","key":"2026102802074387900_cit52","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202423643","article-title":"Quantum Dots-Engineered Flexible Hydrogel as Plant-Wearable Sensor for on-Site Profiling Dynamic Pesticide Degradation","volume":"35","author":"Chen","year":"2025","journal-title":"Adv. Funct. 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