{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:47:09Z","timestamp":1792511229908,"version":"4.5.0"},"reference-count":51,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014996","name":"Health Commission of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY1245"],"award-info":[{"award-number":["2024KY1245"]}],"id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014996","name":"Health Commission of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY1257"],"award-info":[{"award-number":["2024KY1257"]}],"id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Clinovation Pride Necrotizing soft tissue infection","award":["CXTD202501043"],"award-info":[{"award-number":["CXTD202501043"]}]},{"name":"Municipal Science and Technology Bureau Foundation of Wenzhou","award":["GK20250078"],"award-info":[{"award-number":["GK20250078"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diabetic wounds are characterized by persistent inflammation, endothelial dysfunction, impaired angiogenesis, and poor local retention of therapeutic agents, all of which hinder effective repair. Here, we combined Netrin-1-enriched exosomes (NTN-Exos) from genetically modified adipose-derived stem cells with a photo-crosslinkable phenylboronic acid-modified hyaluronic acid methacryloyl\/polyvinyl alcohol (HAMA-PBA\/PVA) hydrogel to create a diabetic wound-responsive exosome\u2013hydrogel system. NTN-Exos@Gel enabled prolonged local exosome retention owing to its favorable injectability, biocompatibility, and pH- and reactive oxygen species-responsive degradation and release behavior. In vitro, NTN-Exos reduced high-glucose-induced endothelial apoptosis and restored endothelial migration, proliferation, and tube-forming capacity. Additionally, NTN-Exos reduced inflammatory reactions and promoted macrophage polarization toward a reparative phenotype. NTN-Exos@Gel dramatically accelerated wound closure, improved blood perfusion, boosted neovascularization, improved re-epithelialization and collagen deposition, and decreased local inflammatory cytokine production in a diabetic full-thickness wound model. Mechanistically, transcriptome and protein analysis showed that the pro-angiogenic action of NTN-Exos was associated with altered Hippo signaling, which is typified by higher YAP\/TAZ expression, decreased phosphorylation of LATS1 and YAP, and increased expression of CD146. These results suggest that NTN-Exos@Gel is a viable cell-free approach for the healing of diabetic wounds.<\/jats:p>","DOI":"10.1021\/acsami.6c16731","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:02:12Z","timestamp":1792508532000},"source":"Crossref","is-referenced-by-count":0,"title":["A Diabetic Wound Microenvironment-Responsive HAMA-PBA\/PVA Hydrogel for Localized Delivery of Netrin-1-Enriched Adipose-Derived Stem Cell-Derived Exosomes Promotes Diabetic Wound Healing through Immunomodulation and Angiogenesis"],"prefix":"10.1021","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5330-4493","authenticated-orcid":true,"given":"Yanming","family":"Chen","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Wenzhou Medical University , , , ,","place":["Wenzhou, Zhejiang, China, 325000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucang","family":"He","sequence":"additional","affiliation":[{"name":"The 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